View source for EIF2S3

{{Infobox_gene}}
'''Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ)''' is a [[protein]] that in humans is encoded by the ''EIF2S3'' [[gene]].<ref name="pmid8106381">{{cite journal | vauthors = Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC | title = Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit | journal = J Biol Chem | volume = 269 | issue = 5 | pages = 3415–22 |date=Mar 1994 | pmid = 8106381 | pmc =  | doi =  }}</ref><ref name="pmid8106381" /><ref name="pmid9736774">{{cite journal | vauthors = Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM | title = Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution | journal = Hum Mol Genet | volume = 7 | issue = 11 | pages = 1725–37 |date=Dec 1998 | pmid = 9736774 | pmc =  | doi =10.1093/hmg/7.11.1725  }}</ref><ref name="pmid9736774" /><ref name="entrez">{{cite web | title = Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968| accessdate = }}</ref>

==Function==

[[Eukaryotic initiation factor|Eukaryotic translation initiation factor]] 2 ([[eIF2]]) functions in the early steps of [[protein synthesis]] by forming a ternary complex with [[Guanosine triphosphate|GTP]] and initiator [[Transfer RNA|tRNA]] and binding to a [[40S]] [[ribosome|ribosomal]] subunit. eIF2 is composed of three subunits, [[EIF2S1|alpha (α)]], [[EIF2S2|beta (β)]], and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.<ref name="entrez"/>

==See also==
* [[eIF2]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | vauthors=Ray MK, Chakraborty A, Datta B |title=Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide |journal=Biochemistry |volume=32 |issue= 19 |pages= 5151–9 |year= 1993 |pmid= 8098621 |doi=10.1021/bi00070a026  |display-authors=etal}}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | vauthors=Brand SR, Kobayashi R, Mathews MB |title=The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8388–95 |year= 1997 |pmid= 9079663 |doi=10.1074/jbc.272.13.8388  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | vauthors=Cai R, Carpick B, Chun RF |title=HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 361–7 |year= 2000 |pmid= 10620360 |doi= 10.1006/abbi.1999.1583 |display-authors=etal}}
*{{cite journal  | vauthors=Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R |title=Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2 |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 1011–8 |year= 2000 |pmid= 10648795 |doi=10.1093/nar/28.4.1011  | pmc=102579  }}
*{{cite journal  | vauthors=Kruger M, Beger C, Li QX |title=Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8566–71 |year= 2000 |pmid= 10900014 |doi=10.1073/pnas.97.15.8566  | pmc=26988  |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | vauthors=Filippova GN, Cheng MK, Moore JM |title=Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development |journal=Dev. Cell |volume=8 |issue= 1 |pages= 31–42 |year= 2005 |pmid= 15669143 |doi=10.1016/j.devcel.2004.10.018  |display-authors=etal}}
*{{cite journal  | vauthors=Marques AC, Dupanloup I, Vinckenbosch N |title=Emergence of young human genes after a burst of retroposition in primates |journal=PLoS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357  | pmc=1251493 |display-authors=etal}}
*{{cite journal  | vauthors=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766–72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150 }}
*{{cite journal  | vauthors=Mikami S, Masutani M, Sonenberg N |title=An efficient mammalian cell-free translation system supplemented with translation factors |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348–57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021 |display-authors=etal}}
*{{cite journal  | vauthors=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells |journal=Mol. Cell. Proteomics |volume=6 |issue= 4 |pages= 575–88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
}}
{{refend}}

{{Initiation factors}}

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