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The genes within the commonly deleted region of chromosome 22. The smaller boxes represent the genes within the commonly deleted region. The larger boxes below the schematic chromosome represent the LCRs. The most common deletion, which is 3Mb, is seen in approximately 70%-80% of patients and occurs between the 2 most distant LCRs. Fifteen to 30% of patients have a slightly smaller 1.5 Mb deletion, and the remainder of patients have a variety of deletions with 1 breakpoint in an LCR.