View source for GDF10

{{Infobox_gene}}

'''Growth differentiation factor 10''' (GDF10) also known as '''bone morphogenetic protein 3B''' (BMP-3B) is a [[protein]] that in humans is encoded by the ''GDF10'' [[gene]].<ref name="Cunningham_1995">{{cite journal |vauthors=Cunningham NS, Jenkins NA, Gilbert DJ, Copeland NG, Reddi AH, Lee SJ | title = Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3 | journal = Growth Factors | volume = 12 | issue = 2 | pages = 99–109 | year = 1995 | pmid = 8679252 | doi = 10.3109/08977199509028956| url = | issn = }}</ref>

GDF10 belongs to the [[transforming growth factor beta superfamily]] that is closely related to [[bone morphogenetic protein]]-3 ([[Bone morphogenetic protein 3|BMP3]]). It plays a role in head formation and may have multiple roles in skeletal [[morphogenesis]].<ref name="Cunningham_1995"/><ref>{{cite journal |vauthors=Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S |title=Bone morphogenetic protein-3 family members and their biological functions |journal=Front Biosci |volume=9 |issue= |pages=1520–9 |year= 2004|pmid=14977563 |doi=10.2741/1355}}</ref> GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.<ref name="Cunningham_1995"/>

In mice, GDF10 mRNA is abundant in the [[brain]], [[inner ear]], [[uterus]], [[prostate]], [[neural tissue]]s, [[blood vessel]]s and [[adipose tissue]] with low expression in [[spleen]] and [[liver]]. It is also present in bone of both adults and [[neonatal]] mice.<ref name="Cunningham_1995"/> Human GDF10 mRNA is found in the cochlea and lung of [[foetus]]es, and in [[testis]], [[retina]], [[pineal gland]], and other neural tissues of adults.<ref>{{cite journal |vauthors=Katoh Y, Katoh M |title=Comparative integromics on BMP/GDF family |journal=Int J Mol Med |volume=17 |issue=5 |pages=951–5 |year=2006 |pmid=16596286 |doi=10.3892/ijmm.17.5.951}}</ref>

==References==
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==Further reading==
{{refbegin|2}}
*{{cite journal  |vauthors=Davila S, Froeling FE, Tan A |title=New genetic associations detected in a host response study to hepatitis B vaccine. |journal=Genes Immun. |volume=11 |issue= 3 |pages= 232–8 |year= 2010 |pmid= 20237496 |doi= 10.1038/gene.2010.1 |display-authors=etal}}
*{{cite journal  |vauthors=Ducy P, Karsenty G |title=The family of bone morphogenetic proteins. |journal=Kidney Int. |volume=57 |issue= 6 |pages= 2207–14 |year= 2000 |pmid= 10844590 |doi= 10.1046/j.1523-1755.2000.00081.x }}
*{{cite journal  |vauthors=Grupe A, Li Y, Rowland C |title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. |journal=Am. J. Hum. Genet. |volume=78 |issue= 1 |pages= 78–88 |year= 2006 |pmid= 16385451 |doi= 10.1086/498851  |pmc=1380225 |display-authors=etal}}
*{{cite journal  |vauthors=Hino J, Takao M, Takeshita N |title=cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b). |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 2 |pages= 304–10 |year= 1996 |pmid= 8670277 |doi= 10.1006/bbrc.1996.0889 |display-authors=etal}}
*{{cite journal  |vauthors=Zhou M, Lucas DA, Chan KC |title=An investigation into the human serum "interactome". |journal=Electrophoresis |volume=25 |issue= 9 |pages= 1289–98 |year= 2004 |pmid= 15174051 |doi= 10.1002/elps.200405866 |display-authors=etal}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241 |display-authors=etal}}
*{{cite journal  |vauthors=Kimura K, Toyooka S, Tsukuda K |title=The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. |journal=Oncol. Rep. |volume=20 |issue= 5 |pages= 1265–8 |year= 2008 |pmid= 18949431 |doi= 10.3892/or_00000139 |display-authors=etal}}
*{{cite journal  |vauthors=Lafont JE, Talma S, Hopfgarten C, Murphy CL |title=Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways. |journal=J. Biol. Chem. |volume=283 |issue= 8 |pages= 4778–86 |year= 2008 |pmid= 18077449 |doi= 10.1074/jbc.M707729200 }}
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{{TGF beta signaling}}
{{TGFβ receptor superfamily modulators}}

[[Category:Developmental genes and proteins]]
[[Category:TGFβ domain]]


{{gene-10-stub}}