View source for Glutamyl aminopeptidase

{{infobox protein
|Name=glutamyl aminopeptidase (aminopeptidase A)
|caption=
|image=
|width=
|HGNCid=3355
|Symbol=ENPEP
|AltSymbols=gp160, CD249
|EntrezGene=2028
|OMIM=138297
|RefSeq=NM_001977
|UniProt=Q07075
|PDB=
|ECnumber=3.4.11.7
|Chromosome=4
|Arm=q
|Band=25
|LocusSupplementaryData=
}}
'''Glutamyl aminopeptidase''' ({{EC number|3.4.11.7}}, ''aminopeptidase A'', ''aspartate aminopeptidase'', ''angiotensinase A'', ''glutamyl peptidase'', ''Ca<sup>2+</sup>-activated glutamate aminopeptidase'', ''membrane aminopeptidase II'', ''antigen BP-1/6C3 of mouse B lymphocytes'', ''L-aspartate aminopeptidase'', ''angiotensinase A2'') is an [[enzyme]] encoded by the {{gene|ENPEP}} [[gene]]. Glutamyl aminopeptidase has also recently been designated '''CD249''' ([[cluster of differentiation]] 249).

Glutamyl aminopeptidase is a zinc-dependent membrane-bound [[aminopeptidase]] that catalyzes the cleavage of [[glutamic acid|glutamatic]] and [[aspartic acid|aspartatic]] amino acid residues from the N-terminus of polypeptides. The enzyme degrades [[vasoconstriction|vasoconstricting]] [[angiotensin II]] into angiotensin III and therefore helps to regulate [[blood pressure]].<ref name="pmid10961935">{{cite journal |vauthors=Reaux A, Iturrioz X, Vazeux G, Fournie-Zaluski MC, David C, Roques BP, Corvol P, Llorens-Cortes C | title = Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure | journal = Biochem. Soc. Trans. | volume = 28 | issue = 4 | pages = 435–40 | year = 2000 | pmid = 10961935 | doi = 10.1042/0300-5127:0280435 }}</ref>

==References==
{{Reflist}}

==External links==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M01.003 M01.003]
* {{MeshName|Glutamyl+aminopeptidase}}

{{Clusters of differentiation}}
{{Proteases}}

[[Category:Clusters of differentiation]]
[[Category:Zinc enzymes]]


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