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==Gp120==
'''gp120''' is a [[glycoprotein]] exposed on the surface of the [[HIV structure and genome|HIV envelope]]. The 120 in its name comes from its [[molecular weight]] of 120 [[Dalton_%28unit%29|kilodaltons]].

The crystal structure of gp120 complexed to D1D2 CD4 and a neutralizing antibody Fab was solved by Peter Kwong in 1998. It is organized with an outer domain, an inner domain with respect to its termini and a [[Beta sheet|bridging sheet]]. The gp120 gene is around 1.5Kb long and codes for around 500 amino acids. Three copies of gp120 form into a trimer that caps the end of [[gp41]].

The [[Human Immunodeficiency Virus]] (HIV) can mutate frequently to stay ahead of the [[immune system]]. There is however a highly conserved region in the [[virus genome]] near its receptor binding site.
The glycoprotein gp120 is anchored to the [[viral membrane]] through non-covalent bonds along with [[gp41]], both coming from a cleaved protein, [[gp160]]. It infects any target cell with a [[CD4]] [[receptor (biochemistry)|receptor]], particularly the [[helper T-cell]], by binding to that receptor. Binding to CD4 is mainly [[electrostatic]] although there are [[van der Waals]] interactions and [[hydrogen bonds]].

The exact mechanism of virus entry into a cell is unknown.  However, gp120 plays a vital role in seeking out receptors on host cells for entry.
== gp120 vaccines ==

Since CD4 receptor binding is the most obvious step in HIV infection, gp120 was among the first targets of [[HIV vaccine]] research. These efforts have been hampered by the chemical and structural properties of gp120, which make it difficult for [[antibodies]] to bind to it; also, it can easily be shed from the virus' surface and captured by [[T-cell]]s due to its loose binding with gp41. This has traditionally been a hindrance in developing gp120 based [[HIV vaccines]]. However, a study published in the February 15, 2007 edition of Nature provides new promise in the field <4><references/>.
The researchers have identified a region of susceptibilty in the gp120 glycoprotein that corresponds to a functional requirement for efficient association with CD4. This conserved region is involved in the metastable attachment of gp120 to CD4, and can potentially be targeted by the broadly neutralizing antibody b12. This study is promising in its prospects for developing a vaccine targeted at the invariant surface.

== Competition ==
The protein gp120 is necessary during the initial binding of HIV to its target cell.  Consequently, anything which binds to gp120's target can block gp120 from binding to a cell by being physically in the way.  Many of these are toxic to the immune system, such as the anti-CD4 monoclonal antibody [[OKT4]].

[[EGCG]], a flavonoid found in [[green tea]], binds to the same CD4 receptor that gp120 binds to, effectively competing for this receptor.  Test tube studies suggested that EGCG concentrations as low as 0.2 mmols/L – the amount of the molecule found in a cup or two of green tea – temporarily reduced HIV-CD4 cell binding by 40%.  Substantial further research is needed both to confirm that this one-time laboratory experiment can be repeated successfully, and also to see whether it has any practical effect.  For example, by binding to CD4, the flavonoid might slow HIV disease progression in a patient, but it might also attract an immune system-destroying antibody response against the non-human flavonoid.

== References ==

* http://www.aidsmap.com/en/docs/4406022B-85D7-4A9B-B700-91336CBB6B18.asp
* http://www.mcld.co.uk/hiv/?q=gp120
* http://www.ebi.ac.uk/interpro/IEntry?ac=IPR000777
* Zhou, Tongqing et al. [http://www.nature.com/nature/journal/v445/n7129/abs/nature05580.html Structural definition of a conserved neutralization epitope on HIV-1 gp120.] Nature, 2007. Vol 445, 15 February 2007, pp 732-737

==See also==
* [[HIV structure and genome]]

[[Category:HIV/AIDS]]

[[pt:Gp120]]
[[de:Gp120]]
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