View source for Heat shock protein family a (hsp70) member 12b

{{Infobox_gene}}

'''Heat shock protein family A (Hsp70) member 12B''' is a [[protein]] that in humans is encoded by the HSPA12B [[gene]].
<ref name="entrez">
{{cite web
| title = Entrez Gene: Heat shock protein family A (Hsp70) member 12B
| url = https://www.ncbi.nlm.nih.gov/gene/116835
| accessdate = 2018-07-16
}}</ref>

==Function==

The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

== References ==

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== Further reading ==

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*{{cite journal |vauthors=Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ |title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition |journal=BMC Genet. |volume=8 |issue= |pages=43 |date=July 2007 |pmid=17601350 |pmc=1933580 |doi=10.1186/1471-2156-8-43 |url=}}
*{{cite journal |vauthors=Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ |title=Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey |journal=Mech. Ageing Dev. |volume=129 |issue=12 |pages=745–51 |date=December 2008 |pmid=18977241 |doi=10.1016/j.mad.2008.09.020 |url=}}
*{{cite journal |vauthors=Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD |title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip |journal=Am. J. Hum. Genet. |volume=85 |issue=5 |pages=628–42 |date=November 2009 |pmid=19913121 |pmc=2775832 |doi=10.1016/j.ajhg.2009.10.014 |url=}}
*{{cite journal |vauthors=Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S |title=Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study |journal=Diabetes Care |volume=33 |issue=10 |pages=2250–3 |date=October 2010 |pmid=20628086 |pmc=2945168 |doi=10.2337/dc10-0452 |url=}}
*{{cite journal |vauthors=Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S |title=Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration |journal=J. Proteome Res. |volume=11 |issue=4 |pages=2533–43 |date=April 2012 |pmid=22360420 |doi=10.1021/pr2012279 |url=}}
*{{cite journal |vauthors=Ma Y, Lu C, Li C, Li R, Zhang Y, Ma H, Zhang X, Ding Z, Liu L |title=Overexpression of HSPA12B protects against cerebral ischemia/reperfusion injury via a PI3K/Akt-dependent mechanism |journal=Biochim. Biophys. Acta |volume=1832 |issue=1 |pages=57–66 |date=January 2013 |pmid=23046810 |doi=10.1016/j.bbadis.2012.10.003 |url=}}
*{{cite journal |vauthors=Li J, Zhang Y, Li C, Xie J, Liu Y, Zhu W, Zhang X, Jiang S, Liu L, Ding Z |title=HSPA12B attenuates cardiac dysfunction and remodelling after myocardial infarction through an eNOS-dependent mechanism |journal=Cardiovasc. Res. |volume=99 |issue=4 |pages=674–84 |date=September 2013 |pmid=23729663 |doi=10.1093/cvr/cvt139 |url=}}
*{{cite journal |vauthors=Zhang R, Wan XJ, Zhang X, Kang QX, Bian JJ, Yu GF, Wang JF, Zhu KM |title=Plasma HSPA12B is a potential predictor for poor outcome in severe sepsis |journal=PLoS ONE |volume=9 |issue=6 |pages=e101215 |date=2014 |pmid=24977412 |pmc=4076283 |doi=10.1371/journal.pone.0101215 |url=}}
*{{cite journal |vauthors=Wu J, Li X, Huang L, Jiang S, Tu F, Zhang X, Ma H, Li R, Li C, Li Y, Ding Z, Liu L |title=HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells |journal=J. Cell. Mol. Med. |volume=19 |issue=3 |pages=544–54 |date=March 2015 |pmid=25545050 |pmc=4369812 |doi=10.1111/jcmm.12464 |url=}}

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