View source for Human respiratory syncytial virus natural history, complications and prognosis

__NOTOC__
{{Human respiratory syncytial virus}}

{{CMG}}; {{AE}} {{Bassel}}

==Natural History==
RSV primarily infects the ciliated epithelial cells of the airways, causing bronchiolitis characterized by mucus in the airways, sloughed epithelial cell debris, and abundant neutrophils. The accumulation of mucus in the airways is a hallmark of RSV-induced lower respiratory infections (LRIs) and can lead to pulmonary obstruction.<ref name="pmid24763387">{{cite journal| author=Meng J, Stobart CC, Hotard AL, Moore ML| title=An overview of respiratory syncytial virus. | journal=PLoS Pathog | year= 2014 | volume= 10 | issue= 4 | pages= e1004016 | pmid=24763387 | doi=10.1371/journal.ppat.1004016 | pmc=3999198 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24763387  }} </ref>

==Complications==
*Bronchiolitis<ref name="pmid25452661">{{cite journal| author=Piedimonte G, Perez MK| title=Respiratory syncytial virus infection and bronchiolitis. | journal=Pediatr Rev | year= 2014 | volume= 35 | issue= 12 | pages= 519-30 | pmid=25452661 | doi=10.1542/pir.35-12-519 | pmc=5029757 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25452661  }} </ref>
*Pneumonia<ref name="pmid25452661">{{cite journal| author=Piedimonte G, Perez MK| title=Respiratory syncytial virus infection and bronchiolitis. | journal=Pediatr Rev | year= 2014 | volume= 35 | issue= 12 | pages= 519-30 | pmid=25452661 | doi=10.1542/pir.35-12-519 | pmc=5029757 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25452661  }} </ref>
*Asthma exacerbation<ref name="pmid21905783">{{cite journal| author=Wu P, Hartert TV| title=Evidence for a causal relationship between respiratory syncytial virus infection and asthma. | journal=Expert Rev Anti Infect Ther | year= 2011 | volume= 9 | issue= 9 | pages= 731-45 | pmid=21905783 | doi=10.1586/eri.11.92 | pmc=3215509 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21905783  }} </ref>
*Otitis media<ref name="pmid32886769">{{cite journal| author=Phillips M, Finelli L, Saiman L, Wang C, Choi Y, Patel J| title=Respiratory Syncytial Virus-associated Acute Otitis Media in Infants and Children. | journal=J Pediatric Infect Dis Soc | year= 2020 | volume= 9 | issue= 5 | pages= 544-550 | pmid=32886769 | doi=10.1093/jpids/piaa094 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32886769  }} </ref>
*Apnea<ref name="urlApnea Induced by Respiratory Syncytial Virus Infection is no... : The Pediatric Infectious Disease Journal">{{cite web |url=https://journals.lww.com/pidj/fulltext/2014/08000/Apnea_Induced_by_Respiratory_Syncytial_Virus.25.aspx |title=Apnea Induced by Respiratory Syncytial Virus Infection is no... : The Pediatric Infectious Disease Journal |format= |work= |accessdate=2023-01-16}}</ref>
*RSV encephalitis 
*Near-miss sudden infant death syndrome 
*RSV myocarditis<ref name="pmid20872156">{{cite journal| author=Mori M, Kawashima H, Nakamura H, Nakagawa M, Kusuda S, Saji T | display-authors=etal| title=Nationwide survey of severe respiratory syncytial virus infection in children who do not meet indications for palivizumab in Japan. | journal=J Infect Chemother | year= 2011 | volume= 17 | issue= 2 | pages= 254-63 | pmid=20872156 | doi=10.1007/s10156-010-0121-1 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20872156  }} </ref><ref name="pmid34527765">{{cite journal| author=Kawashima H, Inagaki N, Nakayama T, Morichi S, Nishimata S, Yamanaka G | display-authors=etal| title=Cardiac Complications Caused by Respiratory Syncytial Virus Infection: Questionnaire Survey and a Literature Review. | journal=Glob Pediatr Health | year= 2021 | volume= 8 | issue=  | pages= 2333794X211044114 | pmid=34527765 | doi=10.1177/2333794X211044114 | pmc=8436282 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=34527765  }} </ref>

==References==

{{Reflist|2}}

[[Category:Viral diseases]]
[[Category:Mononegavirales]]
[[Category:Needs content]]

[[Category:Pediatrics]]
[[Category:Pulmonology]]
[[Category:Disease]]