View source for Hyaluronic acid (intraarticular)

{{DrugProjectFormSinglePage
|authorTag={{AV}}<!--Overview-->
|aOrAn=a
|drugClass=[[cartilaginous defect repair agent]]
|indicationType=treatment
|indication=[[osteoarthritis]] of knee
|adverseReactions=injection site [[pain]], [[injection site reaction]], [[arthralgia]] 


<!--Black Box Warning-->
|blackBoxWarningTitle=Title
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>

* Content

<!--Adult Indications and Dosage-->

<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=For the treatment of [[Osteoarthritis]] of knee


<!--Off-Label Use and Dosage (Adult)-->

<!--Guideline-Supported Use (Adult)-->
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.

<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.

<!--Pediatric Indications and Dosage-->

<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed=There is limited information regarding <i>FDA-Labeled Use</i> of {{PAGENAME}} in pediatric patients.

<!--Off-Label Use and Dosage (Pediatric)-->

<!--Guideline-Supported Use (Pediatric)-->
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.

<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.

<!--Contraindications-->
|contraindications=<!--Warnings-->
|warnings=<!--Adverse Reactions-->

<!--Clinical Trials Experience-->
|clinicalTrials=There is limited information regarding <i>Clinical Trial Experience</i> of {{PAGENAME}} in the drug label.


<!--Postmarketing Experience-->
|postmarketing=There is limited information regarding <i>Postmarketing Experience</i> of {{PAGENAME}} in the drug label.


<!--Drug Interactions-->
|drugInteractions=<!--Use in Specific Populations-->
|useInPregnancyAUS=There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=There is no FDA guidance on the use of {{PAGENAME}} with respect to nursing mothers.
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with [[renal impairment]].
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with [[hepatic impairment]].
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are [[immunocompromised]].

<!--Administration and Monitoring-->
|administration=* Intraarticular
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.


<!--IV Compatibility-->
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.

<!--Overdosage-->
|overdose=There is limited information regarding <i>Chronic Overdose</i> of {{PAGENAME}} in the drug label.

<!--Pharmacology-->

<!--Drug box 2-->
|drugBox={{Chembox2

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 443055112

| ImageFile1 = Hyaluronan.png

| ImageSize1 = 300px

|Section1={{Chembox Identifiers

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = NA

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = S270N0TRQY

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo = 9004-61-9

| CASNo1_Ref = {{cascite|changed|??}}

| CASNo1 = 31799-91-4

| CASNo1_Comment = (potassium salt)

| CASNo2_Ref = {{cascite|changed|??}}

| CASNo2 = 9067-32-7

| CASNo2_Comment = (sodium salt)

| ATCCode_prefix = D03

| ATCCode_suffix = AX05

| ATC_Supplemental = {{ATC|M09|AX01}}, {{ATC|R01|AX09}}, {{ATC|S01|KA01}}

 }}

|Section2={{Chembox Properties

| Formula = (C<sub>14</sub>H<sub>21</sub>NO<sub>11</sub>)<sub>n</sub>

| Solubility = soluble (sodium salt)

 }}

|Section7={{Chembox Hazards

| SPhrases = {{S22}}, {{S24/25}} (sodium salt)

| LD50 = > 2400 mg/kg (mouse, oral, sodium salt) <br /> >4000 mg/kg (mouse, subcutaneous, sodium salt) <br />1500 mg/kg (mouse, intraperitoneal, sodium salt)<ref name="ChemIDplus">{{ChemID|9067-32-7|Hyaluronate Sodium}}, consulté le 12 février 2009</ref>

 }}

|Section8={{Chembox Related

| OtherCpds = [[D-glucuronic acid]] and [[D-N-acetylglucosamine]] (monomers)

 }}

}}

<!--Mechanism of Action-->
|mechAction=<!--Structure-->
|structure=<!--Pharmacodynamics-->
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.

<!--Pharmacokinetics-->
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.

<!--Nonclinical Toxicology-->
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.

<!--Clinical Studies-->
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.

<!--How Supplied-->
|howSupplied=*3mL in a 10mL Single Use Syringe.
*Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature]. Protect from freezing.

<!--Patient Counseling Information-->
|fdaPatientInfo=There is limited information regarding <i>Patient Counseling Information</i> of {{PAGENAME}} in the drug label.

<!--Precautions with Alcohol-->
|alcohol=<!--Brand Names-->
|brandNames=<!--Look-Alike Drug Names-->
|lookAlike=<!--Drug Shortage Status-->
|drugShortage=
}}
<!--Pill Image-->



<!--Label Display Image-->

{{LabelImage
|fileName={{PAGENAME}}03.png|This image is provided by the National Library of Medicine.
}}

{{LabelImage
|fileName={{PAGENAME}}04.png|This image is provided by the National Library of Medicine.
}}

<!--Category-->

[[Category:Drug]]