View source for Idiopathic infantile arterial calcification natural history, complications and prognosis

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{{Idiopathic infantile arterial calcification}}
{{CMG}};  {{AE}} {{AO}}

==Overview==

==Natural History, Complication and Prognosis==
*Although survival to adulthood has been reported,<ref>{{cite journal |doi=10.1016/S0022-3476(84)80123-7 |title=Generalized arterial calcification of infancy: Three case reports, including spontaneous regression with long-term survival |year=1984 |last1=Sholler |first1=Gary F. |last2=Yu |first2=John S. |last3=Bale |first3=Patricia M. |last4=Hawker |first4=Richard E. |last5=Celermajer |first5=John M.|last6=Kozlowski |first6=Kasimir |journal=The Journal of Pediatrics |volume=105 |issue=2 |pages=257–60 |pmid=6747757}}</ref><ref>{{cite journal |doi=10.1007/BF02424963 |title=Idiopathic infantile arterial calcification with survival to adult life |year=1984|last1=Marrott|first1=Pran K. |last2=Newcombe |first2=Ken D. |last3=Becroft |first3=David M. O. |last4=Friedlander |first4=Denis H.|journal=Pediatric Cardiology |volume=5 |issue=2 |pages=119–22 |pmid=6473121}}</ref> sometimes with persistent hypertension and cardiovascular sequelae, most patients die within the first 6 months of life. 
*Spontaneous regression of arterial calcifications can occur, and antihypertensive treatment can be tapered off gradually. In some patients, the natural course of GACI may be more favourable than previously assumed.<ref>{{cite journal |doi=10.1007/s00431-005-0035-6|title=Generalized arterial calcification of infancy: Two siblings with prolonged survival |year=2005 |last1=Ciana|first1=Giovanni|last2=Trappan |first2=Antonella |last3=Bembi |first3=Bruno |last4=Benettoni |first4=Alessandra |last5=Maso |first5=Giampaolo|last6=Zennaro|first6=Floriana |last7=Ruf |first7=Nico |last8=Schnabel |first8=Dirk |last9=Rutsch |first9=Frank |journal=European Journal of Pediatrics|volume=165 |issue=4 |pages=258–63 |pmid=16315058}}</ref><ref>{{cite journal |doi=10.1007/BF00857661 |title=Idiopathic arterial calcification of infancy: A case with prolonged survival |year=1990 |last1=Thomas |first1=Philomena |last2=Chandra |first2=Manju |last3=Kahn|first3=Ellen|last4=McVicar |first4=Melinda |last5=Naidich |first5=James |last6=Lacorte |first6=Michael |journal=Pediatric Nephrology|volume=4 |issue=3|pages=233–5 |pmid=2400650}}</ref>
*Despite the same [[genotype]] and similar sonographic and radiographic features in early infancy, the phenotype of IIAC can vary to a great extent within one family.<ref>{{cite journal |doi=10.1002/ajmg.a.30800 |title=Generalized arterial calcification of infancy: Different clinical courses in two affected siblings |year=2005 |last1=Cheng |first1=Kun-Shan |last2=Chen |first2=Ming-Ren |last3=Ruf|first3=Nico|last4=Lin |first4=Shuan-Pei |last5=Rutsch |first5=Frank |journal=American Journal of Medical Genetics Part A |volume=136A|issue=2|pages=210–3}}</ref>

== References ==
{{reflist|2}}

[[Category:Idiopathic diseases]]
[[Category:Autosomal recessive disorders]]

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