View source for KLRA1

{{Infobox nonhuman protein
| Name = killer cell lectin-like receptor, subfamily A, member 2
| image = 
| width = 
| caption = 
| Organism = Mus musculus
| TaxID = 10090
| Symbol = Klra2
| AltSymbols = Ly49b; Klra30
| EntrezGene = 16633
| PDB = 
| RefSeqmRNA = NM_008462.5
| RefSeqProtein = NP_032488.4
| UniProt = Q60660
| ECnumber = 
| Chromosome = 6
| EntrezChromosome = NC_000072.6
| GenLoc_start = 131215015
| GenLoc_end = 131251580
}}
{{infobox protein
|Name= Killer cell lectin-like receptor subfamily A pseudogene 1
|caption=
|image=
|width=
|HGNCid=6372
|Symbol= KLRAP1
|AltSymbols= KLRA1; Ly49; LY49L; Ly-49L
|EntrezGene=10748
|OMIM=604274
|RefSeq=NM_006611
|UniProt=O75889
|PDB=
|ECnumber=
|Chromosome=12
|Arm=p
|Band=12
|LocusSupplementaryData=-p13
}}
'''Ly-49 receptors''' or '''killer cell lectin-like receptor subfamily A''' ('''KLRA'''), are a class of [[natural killer cell]] receptor.<ref name="pmid15593300">{{cite journal |vauthors=Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S | title = The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex | journal = Eur. J. Immunol. | volume = 35 | issue = 1 | pages = 261–72 |date=January 2005 | pmid = 15593300 | doi = 10.1002/eji.200425429  }}</ref><ref name="pmid17056508">{{cite journal |vauthors=Gays F, Aust JG, Reid DM, Falconer J, Toyama-Sorimachi N, Taylor PR, Brooks CG | title = Ly49B is expressed on multiple subpopulations of myeloid cells | journal = J. Immunol. | volume = 177 | issue = 9 | pages = 5840–51 |date=November 2006 | pmid = 17056508 | doi = 10.4049/jimmunol.177.9.5840}}</ref> Ly-49 proteins are a diverse set of C-type [[lectin]]s that are expressed on NK cells in some mammals, including rodents but not humans. Their primary function is to bind host [[MHC class I]] as a mechanism of self/health recognition. Upon binding ligands, most Ly-49 receptors will deliver an inhibitory signal, preventing killing of the target cell. In the case of cancer or virally infected cells, MHC-I will often be downregulated in order to limit [[cytotoxic T cell]] mediated killing of the cell, whereby NK cells will lack Ly-49 inhibitory signal and be able to kill infected or cancerous target cells.

The homologous human KLRAP1 [[gene]] has been classified as a transcribed pseudogene because all associated transcripts are candidates for [[nonsense-mediated decay]] (NMD).<ref name="pmid10369937">{{cite journal |vauthors=Barten R, Trowsdale J | title = The human Ly-49L gene | journal = Immunogenetics | volume = 49 | issue = 7-8 | pages = 731–4 |date=July 1999 | pmid = 10369937 | doi = 10.1007/s002510050675}}</ref><ref name="pmid16492762">{{cite journal |vauthors=Hao L, Klein J, Nei M | title = Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 9 | pages = 3192–7 |date=February 2006 | pmid = 16492762 | pmc = 1413923 | doi = 10.1073/pnas.0511280103 }}</ref>

==References==
{{Reflist}}

==External links==
* {{MeshName|Ly-49+antigen}}


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