View source for Kir2.6

{{DISPLAYTITLE:K<sub>ir</sub>2.6}}
{{protein
|Name=potassium inwardly-rectifying channel, subfamily J, member 18
|caption=
|image=
|width=
|HGNCid=39080
|Symbol=KCNJ18
|AltSymbols=
|EntrezGene=100134444
|OMIM=613236
|RefSeq=NM_001194958
|UniProt=B7U540
|PDB=
|ECnumber=
|Chromosome=17
|Arm=p
|Band=11.2
|LocusSupplementaryData=
}}
The '''K<sub>ir</sub>2.6''' also known as '''inward rectifier potassium channel 18''' is a protein that in humans is encoded by the ''KCNJ18'' [[gene]].<ref name=Ryan>{{cite journal  |vauthors=Ryan DP, da Silva MR, Soong TW, etal |title=Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis |journal=Cell |volume=140 |issue=1 |pages=88–98 |date=January 2010 |pmid=20074522 |pmc=2885139 |doi=10.1016/j.cell.2009.12.024}}</ref> K<sub>ir</sub>2.6 is an [[inward-rectifier potassium ion channel]]. 

== Function ==

Inwardly rectifying potassium channels, such as K<sub>ir</sub>2.6, maintain resting membrane potential in excitable cells and aid in repolarization of cells following depolarization. K<sub>ir</sub>2.6 is primarily expressed in skeletal muscle and is transcriptionally regulated by [[thyroid hormone]].<ref name=Ryan/>

== Clinical signifiance ==

Mutations in this gene have been linked to [[thyrotoxic periodic paralysis]].<ref name=Ryan/>

==References==
{{reflist}}

{{membrane-protein-stub}}
{{NLM content}}
{{Ion channels|g3}}

[[Category:Ion channels]]