View source for LILRB2

{{Use dmy dates|date=April 2013}}
{{Infobox_gene}}
'''Leukocyte immunoglobulin-like receptor subfamily B member 2''' is a [[protein]] that in humans is encoded by the ''LILRB2'' [[gene]].<ref name="pmid9151699">{{cite journal |vauthors=Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M | title = A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing | journal = J Exp Med | volume = 185 | issue = 10 | pages = 1743–51 |date=Jun 1997 | pmid = 9151699 | pmc = 2196312 | doi =10.1084/jem.185.10.1743  }}</ref><ref name="pmid9079806">{{cite journal |vauthors=Samaridis J, Colonna M | title = Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways | journal = Eur J Immunol | volume = 27 | issue = 3 | pages = 660–5 |date=Apr 1997 | pmid = 9079806 | pmc =  | doi =10.1002/eji.1830270313  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10288| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the [[leukocyte immunoglobulin-like receptor]] (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
}}

==Interactions==
LILRB2 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]].<ref name=pmid9842885>{{cite journal |last=Fanger |first=N A |authorlink= |author2=Cosman D |author3=Peterson L |author4=Braddy S C |author5=Maliszewski C R |author6=Borges L  |date=Nov 1998 |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes |journal=Eur. J. Immunol. |volume=28 |issue=11 |pages=3423–34 |publisher= |location = GERMANY| issn = 0014-2980| pmid = 9842885 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2 }}</ref><ref name=pmid9531263>{{cite journal |last=Colonna |first=M |authorlink= |author2=Samaridis J |author3=Cella M |author4=Angman L |author5=Allen R L |author6=O'Callaghan C A |author7=Dunbar R |author8=Ogg G S |author9=Cerundolo V |author10=Rolink A  |date=Apr 1998 |title=Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules |journal=J. Immunol. |volume=160 |issue=7 |pages=3096–100 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 9531263 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

==See also==
* [[Cluster of differentiation]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Suciu-Foca N, Cortesini R |title=Central role of ILT3 in the T suppressor cell cascade. |journal=Cell. Immunol. |volume=248 |issue= 1 |pages= 59–67 |year= 2007 |pmid= 17923119 |doi= 10.1016/j.cellimm.2007.01.013 }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal   |vauthors=Wagtmann N, Rojo S, Eichler E, etal |title=A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 615–8 |year= 1997 |pmid= 9259559 |doi=10.1016/S0960-9822(06)00263-6  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal   |vauthors=Colonna M, Navarro F, Bellón T, etal |title=A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells |journal=J. Exp. Med. |volume=186 |issue= 11 |pages= 1809–18 |year= 1997 |pmid= 9382880 |doi=10.1084/jem.186.11.1809  | pmc=2199153  }}
*{{cite journal   |vauthors=Colonna M, Samaridis J, Cella M, etal |title=Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules |journal=J. Immunol. |volume=160 |issue= 7 |pages= 3096–100 |year= 1998 |pmid= 9531263 |doi=  }}
*{{cite journal   |vauthors=Borges L, Hsu ML, Fanger N, etal |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192–6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal   |vauthors=Fanger NA, Cosman D, Peterson L, etal |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes |journal=Eur. J. Immunol. |volume=28 |issue= 11 |pages= 3423–34 |year= 1998 |pmid= 9842885 |doi=10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2  }}
*{{cite journal   |vauthors=Allan DS, Colonna M, Lanier LL, etal |title=Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells |journal=J. Exp. Med. |volume=189 |issue= 7 |pages= 1149–56 |year= 1999 |pmid= 10190906 |doi=10.1084/jem.189.7.1149  | pmc=2193000  }}
*{{cite journal   |vauthors=Lepin EJ, Bastin JM, Allan DS, etal |title=Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors |journal=Eur. J. Immunol. |volume=30 |issue= 12 |pages= 3552–61 |year= 2001 |pmid= 11169396 |doi=10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L  }}
*{{cite journal   |vauthors=Young NT, Canavez F, Uhrberg M, etal |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=10.1007/s002510100332  }}
*{{cite journal   |vauthors=Chang CC, Ciubotariu R, Manavalan JS, etal |title=Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 |journal=Nat. Immunol. |volume=3 |issue= 3 |pages= 237–43 |year= 2002 |pmid= 11875462 |doi= 10.1038/ni760 }}
*{{cite journal   |vauthors=Willcox BE, Thomas LM, Chapman TL, etal |title=Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18 |journal=BMC Struct. Biol. |volume=2|pages= 6 |year= 2003 |pmid= 12390682 |doi=10.1186/1472-6807-2-6  | pmc=130215  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal   |vauthors=Shiroishi M, Tsumoto K, Amano K, etal |title=Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8856–61 |year= 2003 |pmid= 12853576 |doi= 10.1073/pnas.1431057100  | pmc=166403 |bibcode=2003PNAS..100.8856S }}
*{{cite journal   |vauthors=Nakajima H, Asai A, Okada A, etal |title=Transcriptional regulation of ILT family receptors |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6611–20 |year= 2004 |pmid= 14662864 |doi=  10.4049/jimmunol.171.12.6611}}
*{{cite journal  |vauthors=Papanikolaou NA, Vasilescu ER, Suciu-Foca N |title=Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4 |journal=Hum. Immunol. |volume=65 |issue= 7 |pages= 700–5 |year= 2005 |pmid= 15301858 |doi= 10.1016/j.humimm.2004.04.003 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
}}
{{refend}}
{{PDB Gallery|geneid=10288}}

==External links==
* {{MeshName|LILRB2+protein,+human}}
* {{UCSC genome browser|LILRB2}}
* {{UCSC gene details|LILRB2}}

{{NLM content}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Immunoglobulin superfamily]]


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