View source for Lipopolysaccharide binding protein

{{Infobox_gene}}
'''Lipopolysaccharide binding protein''' is a [[protein]] that in humans is encoded by the ''LBP'' [[gene]].<ref name="pmid8432532">{{cite journal |vauthors=Gray PW, Corcorran AE, ((Eddy RL Jr)), Byers MG, Shows TB | title = The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20 | journal = Genomics | volume = 15 | issue = 1 | pages = 188–90 |date=March 1993 | pmid = 8432532 | pmc =  | doi = 10.1006/geno.1993.1030 }}</ref><ref name="entrez"/>

LBP is a soluble [[acute-phase protein]] that binds to bacterial [[lipopolysaccharide]] (or LPS) to elicit immune responses by presenting the LPS to important cell surface [[pattern recognition receptor]]s called [[CD14]] and [[Toll-like receptor|TLR4]].<ref>{{cite journal |vauthors=Muta T, Takeshige K |title=Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations |journal=Eur. J. Biochem. |volume=268 |issue=16 |pages=4580–9 |year=2001 |pmid=11502220 |doi=10.1046/j.1432-1327.2001.02385.x}}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with [[Bactericidal/permeability-increasing protein|bactericidal permeability-increasing protein]] (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.<ref name="entrez">{{cite web | title = Entrez Gene: LBP lipopolysaccharide binding protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3929| accessdate = }}</ref>
}}

==Interactions==
Lipopolysaccharide-binding protein has been shown to [[Protein-protein interaction|interact]] with [[CD14]], [[TLR2]], [[TLR4]] and the co-receptor MD-2.<ref name=pmid12417309>{{cite journal |last=Thomas |first=Celestine J |authorlink= |author2=Kapoor Mili |author3=Sharma Shilpi |author4=Bausinger Huguette |author5=Zyilan Umit |author6=Lipsker Dan |author7=Hanau Daniel |author8=Surolia Avadhesha  |date=November 2002  |title=Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response |journal=FEBS Lett. |volume=531 |issue=2 |pages=184–8 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12417309 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(02)03499-3 }}</ref><ref name=pmid7583357>{{cite journal |last=Yu |first=B |authorlink= |author2=Wright S D  |year=1995|title=LPS-dependent interaction of Mac-2-binding protein with immobilized CD14 |journal=J. Inflamm. |volume=45 |issue=2 |pages=115–25 |publisher= |location = UNITED STATES| issn = 1078-7852| pmid = 7583357 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid15272059>{{cite journal | doi= 10.1099/jmm.0.45598-0 | pmid= 15272059 | year= 2004 | last1= Erridge | first1= C | last2= Pridmore | first2= A | last3= Eley | first3= A | last4= Stewart | first4= J | last5= Poxton | first5= IR | title= Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2. | volume= 53 | issue= Pt 8 | pages= 735–40 | journal= Journal of Medical Microbiology}}</ref>

==References==
{{reflist|2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Schumann RR, Leong SR, Flaggs GW, etal |title=Structure and function of lipopolysaccharide binding protein. |journal=Science |volume=249 |issue= 4975 |pages= 1429–31 |year= 1990 |pmid= 2402637 |doi=10.1126/science.2402637  |bibcode=1990Sci...249.1429S }}
*{{cite journal   |vauthors=Wilde CG, Seilhamer JJ, McGrogan M, etal |title=Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. |journal=J. Biol. Chem. |volume=269 |issue= 26 |pages= 17411–6 |year= 1994 |pmid= 7517398 |doi=  }}
*{{cite journal  |vauthors=Park CT, Wright SD |title=Plasma lipopolysaccharide-binding protein is found associated with a particle containing apolipoprotein A-I, phospholipid, and factor H-related proteins. |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18054–60 |year= 1996 |pmid= 8663389 |doi=10.1074/jbc.271.30.18054  }}
*{{cite journal  |vauthors=Nanbo A, Nishimura H, Nagasawa S |title=Lipopolysaccharide binding protein from normal human plasma purified with high efficiency. |journal=Protein Expr. Purif. |volume=10 |issue= 1 |pages= 55–60 |year= 1997 |pmid= 9179291 |doi= 10.1006/prep.1996.0712 }}
*{{cite journal  |vauthors=Hubacek JA, Büchler C, Aslanidis C, Schmitz G |title=The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 427–30 |year= 1997 |pmid= 9240454 |doi= 10.1006/bbrc.1997.6970 }}
*{{cite journal   |vauthors=Jack RS, Fan X, Bernheiden M, etal |title=Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. |journal=Nature |volume=389 |issue= 6652 |pages= 742–5 |year= 1997 |pmid= 9338787 |doi= 10.1038/39622 |bibcode=1997Natur.389..742J }}
*{{cite journal   |vauthors=Kirschning CJ, Au-Young J, Lamping N, etal |title=Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins. |journal=Genomics |volume=46 |issue= 3 |pages= 416–25 |year= 1998 |pmid= 9441745 |doi= 10.1006/geno.1997.5030 }}
*{{cite journal  |vauthors=Beamer LJ, Carroll SF, Eisenberg D |title=The BPI/LBP family of proteins: a structural analysis of conserved regions |journal=Protein Sci. |volume=7 |issue= 4 |pages= 906–14 |year= 1998 |pmid= 9568897 |doi=10.1002/pro.5560070408  | pmc=2143972  }}
*{{cite journal  |vauthors=Sato M, Saeki Y, Tanaka K, Kaneda Y |title=Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system |journal=Biochem. Biophys. Res. Commun. |volume=256 |issue= 2 |pages= 385–90 |year= 1999 |pmid= 10079194 |doi= 10.1006/bbrc.1999.0343 }}
*{{cite journal   |vauthors=Vreugdenhil AC, Dentener MA, Snoek AM, etal |title=Lipopolysaccharide binding protein and serum amyloid A secretion by human intestinal epithelial cells during the acute phase response |journal=Journal of Immunology |volume=163 |issue= 5 |pages= 2792–8 |year= 1999 |pmid= 10453023 |doi=  }}
*{{cite journal   |vauthors=Vesy CJ, Kitchens RL, Wolfbauer G, etal |title=Lipopolysaccharide-Binding Protein and Phospholipid Transfer Protein Release Lipopolysaccharides from Gram-Negative Bacterial Membranes |journal=Infect. Immun. |volume=68 |issue= 5 |pages= 2410–7 |year= 2000 |pmid= 10768924 |doi=10.1128/IAI.68.5.2410-2417.2000  | pmc=97439  }}
*{{cite journal   |vauthors=Labéta MO, Vidal K, Nores JE, etal |title=Innate Recognition of Bacteria in Human Milk Is Mediated by a Milk-Derived Highly Expressed Pattern Recognition Receptor, Soluble Cd14 |journal=J. Exp. Med. |volume=191 |issue= 10 |pages= 1807–12 |year= 2000 |pmid= 10811873 |doi=10.1084/jem.191.10.1807  | pmc=2193148  }}
*{{cite journal   |vauthors=Dentener MA, Vreugdenhil AC, Hoet PH, etal |title=Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: implications for local defense to bacterial endotoxins |journal=Am. J. Respir. Cell Mol. Biol. |volume=23 |issue= 2 |pages= 146–53 |year= 2000 |pmid= 10919979 |doi=  10.1165/ajrcmb.23.2.3855}}
*{{cite journal   |vauthors=Nagaoka I, Hirota S, Niyonsaba F, etal |title=Cathelicidin family of antibacterial peptides CAP18 and CAP11 inhibit the expression of TNF-alpha by blocking the binding of LPS to CD14(+) cells |journal=Journal of Immunology |volume=167 |issue= 6 |pages= 3329–38 |year= 2001 |pmid= 11544322 |doi=  10.4049/jimmunol.167.6.3329}}
*{{cite journal   |vauthors=Gutsmann T, Müller M, Carroll SF, etal |title=Dual Role of Lipopolysaccharide (LPS)-Binding Protein in Neutralization of LPS and Enhancement of LPS-Induced Activation of Mononuclear Cells |journal=Infect. Immun. |volume=69 |issue= 11 |pages= 6942–50 |year= 2001 |pmid= 11598069 |doi= 10.1128/IAI.69.11.6942-6950.2001  | pmc=100074 }}
*{{cite journal   |vauthors=Iovine N, Eastvold J, Elsbach P, etal |title=The carboxyl-terminal domain of closely related endotoxin-binding proteins determines the target of protein-lipopolysaccharide complexes |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7970–8 |year= 2002 |pmid= 11773072 |doi= 10.1074/jbc.M109622200 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
*{{cite journal  |vauthors=Kaden J, Zwerenz P, Lambrecht HG, Dostatni R |title=Lipopolysaccharide-binding protein as a new and reliable infection marker after kidney transplantation |journal=Transpl. Int. |volume=15 |issue= 4 |pages= 163–72 |year= 2002 |pmid= 11976738 |doi= 10.1007/s00147-002-0392-2 }}
*{{cite journal   |vauthors=Reyes O, Vallespi MG, Garay HE, etal |title=Identification of single amino acid residues essential for the binding of lipopolysaccharide (LPS) to LPS binding protein (LBP) residues 86-99 by using an Ala-scanning library |journal=J. Pept. Sci. |volume=8 |issue= 4 |pages= 144–50 |year= 2002 |pmid= 11991204 |doi= 10.1002/psc.375 }}
}}
{{refend}}

==External links==
* {{MeshName|lipopolysaccharide-binding+protein}}

{{NLM content}}

{{TLR signaling pathway}}
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[[Category:Acute phase proteins]]