View source for MAP3K2

{{Infobox_gene}}
'''Mitogen-activated protein kinase kinase kinase 2''' is an [[enzyme]] that in humans is encoded by the ''MAP3K2'' [[gene]].<ref name="pmid8621389">{{cite journal | vauthors = Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL | title = Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 10 | pages = 5361–8 | date = Mar 1996 | pmid = 8621389 | pmc =  | doi = 10.1074/jbc.271.10.5361 }}</ref><ref name="pmid10085062">{{cite journal | vauthors = Zhao Q, Lee FS | title = Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8355–8 | date = Mar 1999 | pmid = 10085062 | pmc =  | doi = 10.1074/jbc.274.13.8355 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP3K2 mitogen-activated protein kinase kinase kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10746| accessdate = }}</ref>

== Function ==

The protein encoded by this gene is a member of [[serine/threonine protein kinase]] family. This [[kinase]] preferentially activates other kinases involved in the [[MAP kinase]] [[signaling pathway]]. This kinase has been shown to directly phosphorylate and activate [[IkappaB kinase]]s, and thus plays a role in [[NF-kappa B]] signaling pathway. This kinase has also been found to bind and activate [[protein kinase C]][[PRK2|-related kinase 2]], which suggests its involvement in a regulated signaling process.<ref name="entrez" />

== Interactions ==

MAP3K2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[MAP2K5]],<ref name = pmid11073940/> 
* [[MAP2K7]],<ref name = pmid10713157>{{cite journal | vauthors = Cheng J, Yang J, Xia Y, Karin M, Su B | title = Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2334–42 | date = Apr 2000 | pmid = 10713157 | pmc = 85399 | doi =  10.1128/mcb.20.7.2334-2342.2000}}</ref> 
* [[MAPK8]],<ref name = pmid10713157/>
* [[SH2D2A]],<ref name = pmid11073940>{{cite journal | vauthors = Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL | title = MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5093–100 | date = Feb 2001 | pmid = 11073940 | doi = 10.1074/jbc.M003719200 }}</ref>  and
* [[XIAP]]<ref name = pmid18761086>{{cite journal | vauthors = Winsauer G, Resch U, Hofer-Warbinek R, Schichl YM, de Martin R | title = XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2 | journal = Cellular Signalling | volume = 20 | issue = 11 | pages = 2107–12 | date = Nov 2008 | pmid = 18761086 | doi = 10.1016/j.cellsig.2008.08.004 }}</ref> 
{{Div col end}}

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ | title = Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 | journal = Nature | volume = 372 | issue = 6508 | pages = 798–800 | year = 1995 | pmid = 7997270 | doi = 10.1038/372798a0 }}
* {{cite journal | vauthors = Wu Z, Wu J, Jacinto E, Karin M | title = Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7407–16 | date = Dec 1997 | pmid = 9372971 | pmc = 232596 | doi =  10.1128/mcb.17.12.7407}}
* {{cite journal | vauthors = Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR | title = 14-3-3 proteins interact with specific MEK kinases | journal = The Journal of Biological Chemistry | volume = 273 | issue = 6 | pages = 3476–83 | date = Feb 1998 | pmid = 9452471 | doi = 10.1074/jbc.273.6.3476 }}
* {{cite journal | vauthors = Cheng J, Yang J, Xia Y, Karin M, Su B | title = Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2334–42 | date = Apr 2000 | pmid = 10713157 | pmc = 85399 | doi = 10.1128/MCB.20.7.2334-2342.2000 }}
* {{cite journal | vauthors = Sun W, Vincent S, Settleman J, Johnson GL | title = MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase | journal = The Journal of Biological Chemistry | volume = 275 | issue = 32 | pages = 24421–8 | date = Aug 2000 | pmid = 10818102 | doi = 10.1074/jbc.M003148200 }}
* {{cite journal | vauthors = Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell DM, Gibson SB, Keller G, Gelfand EW, Johnson GL | title = MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells | journal = The EMBO Journal | volume = 19 | issue = 20 | pages = 5387–95 | date = Oct 2000 | pmid = 11032806 | pmc = 314024 | doi = 10.1093/emboj/19.20.5387 }}
* {{cite journal | vauthors = Huang J, Tu Z, Lee FS | title = Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity | journal = Biochemical and Biophysical Research Communications | volume = 303 | issue = 2 | pages = 532–40 | date = Apr 2003 | pmid = 12659851 | doi = 10.1016/S0006-291X(03)00387-5 }}
* {{cite journal | vauthors = Nakamura K, Johnson GL | title = PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway | journal = The Journal of Biological Chemistry | volume = 278 | issue = 39 | pages = 36989–92 | date = Sep 2003 | pmid = 12912994 | doi = 10.1074/jbc.C300313200 }}
* {{cite journal | vauthors = Hammaker DR, Boyle DL, Chabaud-Riou M, Firestein GS | title = Regulation of c-Jun N-terminal kinase by MEKK-2 and mitogen-activated protein kinase kinase kinases in rheumatoid arthritis | journal = Journal of Immunology | volume = 172 | issue = 3 | pages = 1612–8 | date = Feb 2004 | pmid = 14734742 | doi = 10.4049/jimmunol.172.3.1612 }}
* {{cite journal | vauthors = Raviv Z, Kalie E, Seger R | title = MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation | journal = Journal of Cell Science | volume = 117 | issue = Pt 9 | pages = 1773–84 | date = Apr 2004 | pmid = 15075238 | doi = 10.1242/jcs.01040 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = Jun 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
* {{cite journal | vauthors = Cheng J, Zhang D, Kim K, Zhao Y, Zhao Y, Su B | title = Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation | journal = Molecular and Cellular Biology | volume = 25 | issue = 14 | pages = 5955–64 | date = Jul 2005 | pmid = 15988011 | pmc = 1168836 | doi = 10.1128/MCB.25.14.5955-5964.2005 }}
* {{cite journal | vauthors = Pelkmans L, Zerial M | title = Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae | journal = Nature | volume = 436 | issue = 7047 | pages = 128–33 | date = Jul 2005 | pmid = 16001074 | doi = 10.1038/nature03866 }}
* {{cite journal | vauthors = Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H | title = Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 6 | issue = 3 | pages = 537–47 | date = Mar 2007 | pmid = 17192257 | doi = 10.1074/mcp.T600062-MCP200 }}
{{refend}}

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[[Category:EC 2.7.11]]