View source for MCEF

{{infobox protein
|Name=AF4/FMR2 family, member 4
|caption=
|image=
|width=
|HGNCid=17869
|Symbol=AFF4
|AltSymbols=
|EntrezGene=27125
|OMIM=604417
|RefSeq=NM_014423
|UniProt=Q9UHB7
|PDB=
|ECnumber=
|Chromosome=5
|Arm=q
|Band=31
|LocusSupplementaryData=
}}
'''MCEF''' or Major [[Cdk9]]-interacting [[elongation factor]] is a [[transcription factor]] related to Af4.  It is the fourth member of the Af4 family (AFF) of transcription factors, involved in numerous pathologies, including [[Acute Lymphoblastic Leukemia]] (ALL), abnormal [[Central nervous system|CNS]] development, [[breast cancer]] and [[azoospermia]].

Because it apparently interacts with the species-specific human co-factor ([[P-TEFb]]) for HIV-1 transcription, and because it can repress HIV-1 replication, MCEF (also known as AFF4 or AF5q31) may have future therapeutic uses.<ref name=Estable>{{cite journal |vauthors=Estable M, Naghavi M, Kato H, Xiao H, Qin J, Vahlne A, Roeder R |title=MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein |journal=J Biomed Sci |volume=9 |issue=3 |pages=234–245 |year=2002 |pmid=12065898 |doi=10.1007/BF02256070}}</ref>

MCEF was originally cloned and named by Mario Clemente Estable of [[Ryerson University]], while he was a post-doctoral fellow in the laboratory of [[Robert G. Roeder]], at the [[Rockefeller University]].

==See also==
[[Transcription factors]]

==References==
<references/>

*{{cite journal |vauthors=Niedzielski MF, Hopewell R, Ismail Z, Estable MC |title=MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription |journal=Int J Biol Sci |volume=3 |issue=4 |pages=225–236 |year=2007 |pmid=17389929 |pmc=1820876}}
* {{MeshName|MCEF+protein,+human}}

[[Category:Transcription factors]]
[[Category:Oncogenes]]


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