View source for MRPL22

{{Infobox_gene}}
'''39S ribosomal protein L22, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPL22'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MRPL22 mitochondrial ribosomal protein L22| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29093| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A [[pseudogene]] corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791  }}
*{{cite journal   |vauthors=Goldschmidt-Reisin S, Kitakawa M, Herfurth E, etal |title=Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 34828–36 |year= 1999 |pmid= 9857009 |doi=10.1074/jbc.273.52.34828  }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  }}
*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
*{{cite journal   |vauthors=Koc EC, Burkhart W, Blackburn K, etal |title=The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. |journal=J. Biol. Chem. |volume=276 |issue= 47 |pages= 43958–69 |year= 2001 |pmid= 11551941 |doi= 10.1074/jbc.M106510200 }}
*{{cite journal  | author=O'Brien TW |title=Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. |journal=Gene |volume=286 |issue= 1 |pages= 73–9 |year= 2002 |pmid= 11943462 |doi=10.1016/S0378-1119(01)00808-3  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
}}
{{refend}}

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{{PDB Gallery|geneid=29093}}
{{GeneticTranslation}}
{{Ribosome subunits}}

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[[Category:Ribosomal proteins]]