View source for MS4A2

{{Infobox_gene}}
'''High affinity immunoglobulin epsilon receptor subunit beta''' is a [[protein]] that in humans is encoded by the ''MS4A2'' [[gene]].<ref name="pmid1386024">{{cite journal |vauthors=Maekawa K, Imagawa N, Tanaka Y, Harada S | title = Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor | journal = FEBS Lett | volume = 302 | issue = 2 | pages = 161–5 |date=Aug 1992 | pmid = 1386024 | pmc =  | doi =10.1016/0014-5793(92)80430-O  }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2206| accessdate = }}</ref>

==Function==
The allergic response involves the binding of [[allergen]] to receptor-bound [[IgE]] followed by cell activation and the release of mediators responsible for the manifestations of [[allergy]]. The [[FcεRI|IgE-receptor]], a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of [[mast cell]]s and [[basophil]]s. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.<ref name="entrez"/>

==See also==
* [[FcεRI]]

==References==
{{Reflist}}

==Further reading==
{{Refbegin| 2}}
{{PBB_Further_reading
| citations =
*{{Cite journal  |vauthors=Jouvin MH, Numerof RP, Kinet JP |title=Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI. |journal=Semin. Immunol. |volume=7 |issue= 1 |pages= 29–35 |year= 1995 |pmid= 7612892 |doi=10.1016/1044-5323(95)90005-5  }}
*{{Cite journal  |vauthors=Wilson BS, Pfeiffer JR, Oliver JM |title=FcepsilonRI signaling observed from the inside of the mast cell membrane. |journal=Mol. Immunol. |volume=38 |issue= 16-18 |pages= 1259–68 |year= 2003 |pmid= 12217393 |doi=10.1016/S0161-5890(02)00073-1  }}
*{{Cite journal  |vauthors=Kraft S, Rana S, Jouvin MH, Kinet JP |title=The role of the FcepsilonRI beta-chain in allergic diseases. |journal=Int. Arch. Allergy Immunol. |volume=135 |issue= 1 |pages= 62–72 |year= 2004 |pmid= 15316148 |doi= 10.1159/000080231 }}
*{{Cite journal   |vauthors=Bieber T, de la Salle H, Wollenberg A, etal |title=Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). |journal=J. Exp. Med. |volume=175 |issue= 5 |pages= 1285–90 |year= 1992 |pmid= 1533242 |doi=10.1084/jem.175.5.1285  | pmc=2119213  }}
*{{Cite journal   |vauthors=Küster H, Zhang L, Brini AT, etal |title=The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. |journal=J. Biol. Chem. |volume=267 |issue= 18 |pages= 12782–7 |year= 1992 |pmid= 1535625 |doi=  }}
*{{Cite journal  |vauthors=Le Coniat M, Kinet JP, Berger R |title=The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23. |journal=Immunogenetics |volume=32 |issue= 3 |pages= 183–6 |year= 1990 |pmid= 2146219 |doi=10.1007/BF02114971  }}
*{{Cite journal  |vauthors=Tedder TF, Streuli M, Schlossman SF, Saito H |title=Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 1 |pages= 208–12 |year= 1988 |pmid= 2448768 |doi=10.1073/pnas.85.1.208  | pmc=279513  }}
*{{Cite journal   |vauthors=Paolini R, Renard V, Vivier E, etal |title=Different roles for the Fc epsilon RI gamma chain as a function of the receptor context. |journal=J. Exp. Med. |volume=181 |issue= 1 |pages= 247–55 |year= 1995 |pmid= 7528770 |doi=10.1084/jem.181.1.247  | pmc=2191817  }}
*{{Cite journal   |vauthors=Shirakawa T, Li A, Dubowitz M, etal |title=Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. |journal=Nat. Genet. |volume=7 |issue= 2 |pages= 125–9 |year= 1994 |pmid= 7920628 |doi= 10.1038/ng0694-125 }}
*{{Cite journal  |vauthors=Kihara H, Siraganian RP |title=Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor. |journal=J. Biol. Chem. |volume=269 |issue= 35 |pages= 22427–32 |year= 1994 |pmid= 8071371 |doi=  }}
*{{Cite journal   |vauthors=Sandford AJ, Shirakawa T, Moffatt MF, etal |title=Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. |journal=Lancet |volume=341 |issue= 8841 |pages= 332–4 |year= 1993 |pmid= 8094113 |doi=10.1016/0140-6736(93)90136-5  }}
*{{Cite journal  |vauthors=Szepetowski P, Gaudray P |title=FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1. |journal=Genomics |volume=19 |issue= 2 |pages= 399–400 |year= 1994 |pmid= 8188278 |doi=10.1006/geno.1994.1083  }}
*{{Cite journal   |vauthors=Daniels SE, Bhattacharrya S, James A, etal |title=A genome-wide search for quantitative trait loci underlying asthma. |journal=Nature |volume=383 |issue= 6597 |pages= 247–50 |year= 1996 |pmid= 8805698 |doi= 10.1038/383247a0 }}
*{{Cite journal  |vauthors=Hill MR, Cookson WO |title=A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. |journal=Hum. Mol. Genet. |volume=5 |issue= 7 |pages= 959–62 |year= 1997 |pmid= 8817330 |doi=10.1093/hmg/5.7.959  }}
*{{Cite journal   |vauthors=Shirakawa T, Mao XQ, Sasaki S, etal |title=Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. |journal=Hum. Mol. Genet. |volume=5 |issue= 8 |pages= 1129–30 |year= 1997 |pmid= 8842731 |doi=10.1093/hmg/5.8.1129  }}
*{{Cite journal   |vauthors=Shirakawa T, Mao XQ, Sasaki S, etal |title=Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. |journal=Hum. Mol. Genet. |volume=5 |issue= 12 |pages= 2068 |year= 1997 |pmid= 8968765 |doi=  }}
*{{Cite journal   |vauthors=Hendricks-Taylor LR, Motto DG, Zhang J, etal |title=SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1363–7 |year= 1997 |pmid= 8995445 |doi=10.1074/jbc.272.2.1363  }}
*{{Cite journal  |vauthors=Kanzaki M, Lindorfer MA, Garrison JC, Kojima I |title=Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14733–9 |year= 1997 |pmid= 9169438 |doi=10.1074/jbc.272.23.14733  }}
}}
{{Refend}}

{{NLM content}}

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{{Other cell membrane proteins}}

[[Category:Fc receptors]]


{{Gene-11-stub}}
{{immunology-stub}}