View source for NEGR1

{{Infobox_gene}}

'''Neuronal growth regulator 1''' also known as '''NEGR1''' is a [[protein]] which in humans is encoded by the ''NEGR1'' [[gene]].<ref name="pmid10075727">{{cite journal | vauthors = Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S | title = Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 8224–30 |date=March 1999 | pmid = 10075727 | doi = 10.1074/jbc.274.12.8224| url =  }}</ref>

== Clinical significance ==

Variants of the NEGR1 gene may be associated with [[obesity]].<ref name="pmid19079260">{{cite journal  |vauthors=Thorleifsson G, Walters GB, Gudbjartsson DF, etal |title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. |journal= Nat. Genet. |volume= 41 |issue= 1 |pages= 18–24 |date=January 2009 |pmid=19079260 |doi= 10.1038/ng.274|url= }}</ref><ref name="pmid19079261">{{cite journal  |vauthors=Willer CJ, Speliotes EK, Loos RJ, etal |title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation |journal= Nat. Genet. |volume= 41 |issue= 1 |pages= 24–34 |date=January 2009 |pmid=19079261 |doi= 10.1038/ng.287|url= |pmc= 2695662 }}</ref><ref name="pmid19478790">{{cite journal  |vauthors=Zhao J, Bradfield JP, Li M, etal |title=The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI |journal=Obesity (Silver Spring) |volume= 17|issue= 12|pages= 2254–7|date=May 2009 |pmid=19478790 |doi=10.1038/oby.2009.159 |pmc=2860782}}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal   |vauthors=Elortza F, Mohammed S, Bunkenborg J, etal |title=Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment |journal=J. Proteome Res. |volume=5 |issue= 4 |pages= 935–43 |year= 2006 |pmid= 16602701 |doi= 10.1021/pr050419u }}
*{{cite journal   |vauthors=Haupt A, Thamer C, Heni M, etal |title=Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study |journal=Obesity (Silver Spring) |volume= 18|issue=  6|pages= 1212–7 |year= 2009 |pmid= 19910938 |doi= 10.1038/oby.2009.413 }}
*{{cite journal   |vauthors=Li S, Zhao JH, Luan J, etal |title=Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies |journal=Am. J. Clin. Nutr. |volume=91 |issue= 1 |pages= 184–90 |year= 2010 |pmid= 19812171 |doi= 10.3945/ajcn.2009.28403 }}
*{{cite journal   |vauthors=Brandys MK, van Elburg AA, Loos RJ, etal |title=Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=153B |issue= 2 |pages= 695–9 |year= 2010 |pmid= 19746409 |doi= 10.1002/ajmg.b.31026 }}
*{{cite journal   |vauthors=Renström F, Payne F, Nordström A, etal |title=Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden |journal=Hum. Mol. Genet. |volume=18 |issue= 8 |pages= 1489–96 |year= 2009 |pmid= 19164386 |doi= 10.1093/hmg/ddp041  |pmc=2664142 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Bauer F, Elbers CC, Adan RA, etal |title=Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference |journal=Am. J. Clin. Nutr. |volume=90 |issue= 4 |pages= 951–9 |year= 2009 |pmid= 19692490 |doi= 10.3945/ajcn.2009.27781 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Hom G, Graham RR, Modrek B, etal |title=Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX |journal=N. Engl. J. Med. |volume=358 |issue= 9 |pages= 900–9 |year= 2008 |pmid= 18204098 |doi= 10.1056/NEJMoa0707865 }}
*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  |pmc=403697 }}
*{{cite journal   |vauthors=Yang Q, Kathiresan S, Lin JP, etal |title=Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study |journal=BMC Med. Genet. |volume=8 Suppl 1|pages= S12 |year= 2007 |pmid= 17903294 |doi= 10.1186/1471-2350-8-S1-S12  |pmc=1995619 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899  |pmc=139241 }}
*{{cite journal   |vauthors=Hotta K, Nakamura M, Nakamura T, etal |title=Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population |journal=J. Hum. Genet. |volume=54 |issue= 12 |pages= 727–31 |year= 2009 |pmid= 19851340 |doi= 10.1038/jhg.2009.106 }}
*{{cite journal   |vauthors=Thorleifsson G, Walters GB, Gudbjartsson DF, etal |title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity |journal=Nat. Genet. |volume=41 |issue= 1 |pages= 18–24 |year= 2009 |pmid= 19079260 |doi= 10.1038/ng.274 }}
{{refend}}

[[Category:Human proteins]]


{{gene-1-stub}}