View source for NMNAT2

{{Infobox_gene}}
'''Nicotinamide mononucleotide adenylyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''NMNAT2'' [[gene]].<ref name="pmid11318611">{{cite journal | vauthors = Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD | title = Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus | journal = Genomics | volume = 73 | issue = 2 | pages = 211–22 |date=Apr 2001 | pmid = 11318611 | pmc =  | doi = 10.1006/geno.2001.6500 }}</ref><ref name="pmid12359228">{{cite journal | vauthors = Raffaelli N, Sorci L, Amici A, Emanuelli M, Mazzola F, Magni G | title = Identification of a novel human nicotinamide mononucleotide adenylyltransferase | journal = Biochem Biophys Res Commun | volume = 297 | issue = 4 | pages = 835–40 |date=Oct 2002 | pmid = 12359228 | pmc =  | doi =10.1016/S0006-291X(02)02285-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NMNAT2 nicotinamide nucleotide adenylyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23057| accessdate = }}</ref>

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{{PBB_Summary
| section_title = 
| summary_text = This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in the [[nicotinamide adenine dinucleotide]] (NAD (NADP)) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />
}}

==References==
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==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal   |vauthors=Seki N, Ohira M, Nagase T, etal |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=10.1093/dnares/4.5.345  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Yalowitz JA, Xiao S, Biju MP, etal |title=Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas |journal=Biochem. J. |volume=377 |issue= Pt 2 |pages= 317–26 |year= 2004 |pmid= 14516279 |doi= 10.1042/BJ20030518  | pmc=1223862 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | vauthors=Berger F, Lau C, Dahlmann M, Ziegler M |title=Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 36334–41 |year= 2006 |pmid= 16118205 |doi= 10.1074/jbc.M508660200 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Sorci L, Cimadamore F, Scotti S, etal |title=Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis |journal=Biochemistry |volume=46 |issue= 16 |pages= 4912–22 |year= 2007 |pmid= 17402747 |doi= 10.1021/bi6023379 }}
}}
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