View source for ORC3L

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Origin recognition complex, subunit 3-like (yeast)
 | HGNCid = 8489
 | Symbol = ORC3L
 | AltSymbols =; LAT; LATHEO; ORC3
 | OMIM = 604972
 | ECnumber =  
 | Homologene = 8225
 | MGIid = 1354944
 | GeneAtlas_image1 = PBB_GE_ORC3L_210028_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003688 |text = DNA replication origin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005664 |text = nuclear origin of replication recognition complex}} 
 | Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23595
    | Hs_Ensembl = ENSG00000135336
    | Hs_RefseqProtein = NP_036513
    | Hs_RefseqmRNA = NM_012381
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 88356562
    | Hs_GenLoc_end = 88433883
    | Hs_Uniprot = Q9UBD5
    | Mm_EntrezGene = 50793
    | Mm_Ensembl = ENSMUSG00000040044
    | Mm_RefseqmRNA = NM_015824
    | Mm_RefseqProtein = NP_056639
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 34758190
    | Mm_GenLoc_end = 34803831
    | Mm_Uniprot = Q3ULT0
  }}
}}
'''Origin recognition complex, subunit 3-like (yeast)''', also known as '''ORC3L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23595| accessdate = }}</ref>

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ORC3L origin recognition complex, subunit 3-like (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23595| accessdate = }}</ref>
}}

==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Tugal T, Zou-Yang XH, Gavin K, ''et al.'' |title=The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p. |journal=J. Biol. Chem. |volume=273 |issue= 49 |pages= 32421-9 |year= 1999 |pmid= 9829972 |doi=  }}
*{{cite journal  | author=Pinto S, Quintana DG, Smith P, ''et al.'' |title=latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant. |journal=Neuron |volume=23 |issue= 1 |pages= 45-54 |year= 1999 |pmid= 10402192 |doi=  }}
*{{cite journal  | author=Springer J, Nanda I, Hoehn K, ''et al.'' |title=Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 245-51 |year= 2000 |pmid= 10702681 |doi=  }}
*{{cite journal  | author=Thome KC, Dhar SK, Quintana DG, ''et al.'' |title=Subsets of human origin recognition complex (ORC) subunits are expressed in non-proliferating cells and associate with non-ORC proteins. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35233-41 |year= 2001 |pmid= 10954718 |doi= 10.1074/jbc.M005765200 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Vashee S, Simancek P, Challberg MD, Kelly TJ |title=Assembly of the human origin recognition complex. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26666-73 |year= 2001 |pmid= 11323433 |doi= 10.1074/jbc.M102493200 }}
*{{cite journal  | author=Dhar SK, Delmolino L, Dutta A |title=Architecture of the human origin recognition complex. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29067-71 |year= 2001 |pmid= 11395502 |doi= 10.1074/jbc.M103078200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Kneissl M, Pütter V, Szalay AA, Grummt F |title=Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. |journal=J. Mol. Biol. |volume=327 |issue= 1 |pages= 111-28 |year= 2003 |pmid= 12614612 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Sibani S, Price GB, Zannis-Hadjopoulos M |title=Ku80 binds to human replication origins prior to the assembly of the ORC complex. |journal=Biochemistry |volume=44 |issue= 21 |pages= 7885-96 |year= 2005 |pmid= 15910003 |doi= 10.1021/bi047327n }}
*{{cite journal  | author=Matsuoka S, Ballif BA, Smogorzewska A, ''et al.'' |title=ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. |journal=Science |volume=316 |issue= 5828 |pages= 1160-6 |year= 2007 |pmid= 17525332 |doi= 10.1126/science.1140321 }}
}}
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