View source for POLD2

{{Infobox_gene}}
'''DNA polymerase delta subunit 2''' is an [[enzyme]] that in humans is encoded by the ''POLD2'' [[gene]].<ref name="pmid8530069">{{cite journal |vauthors=Zhang J, Tan CK, McMullen B, Downey KM, So AG | title = Cloning of the cDNAs for the small subunits of bovine and human DNA polymerase delta and chromosomal location of the human gene (POLD2) | journal = Genomics | volume = 29 | issue = 1 | pages = 179–86 |date=Feb 1996 | pmid = 8530069 | pmc =  | doi = 10.1006/geno.1995.1229 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5425| accessdate = }}</ref> It is a component of the  [[DNA polymerase delta]] complex.

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==Interactions==
POLD2 has been shown to [[Protein-protein interaction|interact]] with [[PCNA]].<ref name=pmid11986310>{{cite journal |last=Lu |first=Xiaoqing |authorlink= |author2=Tan Cheng-Keat |author3=Zhou Jin-Qiu |author4=You Min |author5=Carastro L Michael |author6=Downey Kathleen M |author7=So Antero G  |date=Jul 2002 |title=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |journal=J. Biol. Chem. |volume=277 |issue=27 |pages=24340–5 |publisher= |location = United States| issn = 0021-9258| pmid = 11986310 |doi = 10.1074/jbc.M200065200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  |vauthors=Hindges R, Hübscher U |title=Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). |journal=Genomics |volume=44 |issue= 1 |pages= 45–51 |year= 1997 |pmid= 9286699 |doi= 10.1006/geno.1997.4838 }}
*{{cite journal  | author=Hisama FM |title=WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts |journal=Cancer Res. |volume=60 |issue= 9 |pages= 2372–6 |year= 2000 |pmid= 10811112 |doi=  |name-list-format=vanc| author2=Chen YH  | author3=Meyn MS  | display-authors=3  | last4=Oshima  | first4=J  | last5=Weissman  | first5=SM  }}
*{{cite journal  | author=Mo J |title=Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA |journal=Biochemistry |volume=39 |issue= 24 |pages= 7245–54 |year= 2000 |pmid= 10852724 |doi=10.1021/bi0000871  |name-list-format=vanc| author2=Liu L  | author3=Leon A  | display-authors=3  | last4=Mazloum  | first4=Nayef  | last5=Lee  | first5=Marietta Y. W. T.  }}
*{{cite journal  |vauthors=Perez A, Leon A, Lee MY |title=Characterization of the 5'-flanking region of the gene encoding the 50 kDa subunit of human DNA polymerase delta |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1–2 |pages= 231–6 |year= 2000 |pmid= 10978529 |doi=  10.1016/s0167-4781(00)00153-6}}
*{{cite journal  | author=Szekely AM |title=Werner protein recruits DNA polymerase δ to the nucleolus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 21 |pages= 11365–70 |year= 2000 |pmid= 11027336 |doi= 10.1073/pnas.97.21.11365  | pmc=17206  |name-list-format=vanc| author2=Chen YH  | author3=Zhang C  | display-authors=3  | last4=Oshima  | first4=J  | last5=Weissman  | first5=SM |bibcode=2000PNAS...9711365S}}
*{{cite journal  |vauthors=He H, Tan CK, Downey KM, So AG |title=A tumor necrosis factor α- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase δ and proliferating cell nuclear antigen |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 21 |pages= 11979–84 |year= 2001 |pmid= 11593007 |doi= 10.1073/pnas.221452098  | pmc=59753 |bibcode=2001PNAS...9811979H }}
*{{cite journal  | author=Lu X |title=Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24340–5 |year= 2002 |pmid= 11986310 |doi= 10.1074/jbc.M200065200  |name-list-format=vanc| author2=Tan CK  | author3=Zhou JQ  | display-authors=3  | last4=You  | first4=M  | last5=Carastro  | first5=LM  | last6=Downey  | first6=KM  | last7=So  | first7=AG }}
*{{cite journal  | author=Ohta S |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362–7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200  |name-list-format=vanc| author2=Shiomi Y  | author3=Sugimoto K  | display-authors=3  | last4=Obuse  | first4=C  | last5=Tsurimoto  | first5=T }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Liu L |title=Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen |journal=J. Biol. Chem. |volume=278 |issue= 12 |pages= 10041–7 |year= 2003 |pmid= 12522211 |doi= 10.1074/jbc.M208694200  |name-list-format=vanc| author2=Rodriguez-Belmonte EM  | author3=Mazloum N  | display-authors=3  | last4=Xie  | first4=B  | last5=Lee  | first5=MY }}
*{{cite journal  | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961  |name-list-format=vanc| author2=Cheung J  | author3=MacDonald JR  | display-authors=3  | last4=Osborne  | first4=LR  | last5=Nakabayashi  | first5=K  | last6=Herbrick  | first6=JA  | last7=Carson  | first7=AR  | last8=Parker-Katiraee  | first8=L  | last9=Skaug  | first9=J |bibcode=2003Sci...300..767S}}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Tsurimoto T |title=Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta |journal=Genes Cells |volume=10 |issue= 1 |pages= 13–22 |year= 2005 |pmid= 15670210 |doi= 10.1111/j.1365-2443.2004.00812.x  |name-list-format=vanc| author2=Shinozaki A  | author3=Yano M  | display-authors=3  | last4=Seki  | first4=Masayuki  | last5=Enomoto  | first5=Takemi }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija |bibcode=2005Natur.437.1173R}}
}}
{{refend}}

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{{DNA replication}}


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