View source for PPP2R1A

{{Infobox_gene}}
'''Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2R1A'' [[gene]].<ref name="pmid10446941">{{cite journal |vauthors=Everett AD, Xue C, Stoops T | title = Developmental expression of protein phosphatase 2A in the kidney | journal = J. Am. Soc. Nephrol. | volume = 10 | issue = 8 | pages = 1737–45 |date=August 1999 | pmid = 10446941 | doi = | url = | issn = }}</ref> In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).<ref name="pmid10091592">{{cite journal |vauthors=Haynes JG, Hartung AJ, Hendershot JD, Passingham RS, Rundle SJ | title = Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A | journal = Eur. J. Biochem. | volume = 260 | issue = 1 | pages = 127–136 |date=February 1999 | pmid = 10091592 | doi = 10.1046/j.1432-1327.1999.00154.x| url = | issn = }}</ref>

== Function ==
This gene encodes a constant regulatory subunit of [[protein phosphatase 2]]. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5518| accessdate = }}</ref>

== Interactions ==
PPP2R1A has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[CTTNBP2NL]],<ref name=pmid18782753/>
* [[FAM40A]],<ref name=pmid18782753/>
* [[PPP2CB]],<ref name=pmid18782753/><ref name=pmid12370081/> [[PPP2CA]],<ref name=pmid18782753/><ref name=pmid12370081/> [[PPP4C]],<ref name="pmid18715871">{{cite journal |vauthors=Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC | title = PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4 | journal = J. Biol. Chem. | volume = 283 | issue = 43 | pages = 29273–29284 |date=October 2008 | pmid = 18715871 | pmc = 2662017 | doi = 10.1074/jbc.M803443200 | url = | issn = }}</ref>
* [[PPP2R2A]],<ref name=pmid18782753/><ref name=pmid12370081/>
* [[PPP2R3B]],<ref name="pmid18782753">{{cite journal |vauthors=Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell. Proteomics | volume = 8 | issue = 1 | pages = 157–171 |date=January 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | url = | issn = }}</ref><ref name="pmid12370081">{{cite journal |vauthors=Zhou J, Pham HT, Ruediger R, Walter G | title = Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution | journal = Biochem. J. | volume = 369 | issue = Pt 2 | pages = 387–98 |date=January 2003 | pmid = 12370081 | pmc = 1223084 | doi = 10.1042/BJ20021244 | url = | issn = }}</ref>
* [[PPP2R5A]].<ref name=pmid18782753/><ref name=pmid12370081/>
* [[STK24]],<ref name=pmid18782753/><ref name="pmid17353931">{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1| pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 | url = | issn = }}</ref>
* [[STRN]],<ref name=pmid18782753/> and
* [[STRN3]].<ref name=pmid18782753/>
{{Div col end}}

==Arabidopsis RCN1==
RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.

==References==
{{Reflist}}

==Further reading==
{{Refbegin}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Zolnierowicz S |title=Type 2A protein phosphatase, the complex regulator of numerous signaling pathways |journal=Biochem. Pharmacol. |volume=60 |issue= 8 |pages= 1225–1235 |year= 2000 |pmid= 11007961 |doi=10.1016/S0006-2952(00)00424-X  }}
*{{cite journal  |vauthors=Walter G, Ruediger R, Slaughter C, Mumby M |title=Association of protein phosphatase 2A with polyoma virus medium tumor antigen |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2521–2525 |year= 1990 |pmid= 2157202 |doi=10.1073/pnas.87.7.2521  | pmc=53721  }}
*{{cite journal  | author=Hemmings BA |title=alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure |journal=Biochemistry |volume=29 |issue= 13 |pages= 3166–3173 |year= 1990 |pmid= 2159327 |doi=10.1021/bi00465a002  |name-list-format=vanc| author2=Adams-Pearson C  | author3=Maurer F  | display-authors=3  | last4=Mueller  | first4=Peter  | last5=Goris  | first5=Jozef  | last6=Merlevede  | first6=Wilfried  | last7=Hofsteenge  | first7=Jan  | last8=Stone  | first8=Stuart R.  }}
*{{cite journal  |vauthors=Walter G, Ferre F, Espiritu O, Carbone-Wiley A |title=Molecular cloning and sequence of cDNA encoding polyoma medium tumor antigen-associated 61-kDa protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 22 |pages= 8669–8672 |year= 1989 |pmid= 2554323 |doi=10.1073/pnas.86.22.8669  | pmc=298349  }}
*{{cite journal  |vauthors=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123–26128 |year= 1995 |pmid= 7592815 |doi=10.1074/jbc.270.44.26123  }}
*{{cite journal  | author=Ruediger R |title=Molecular model of the A subunit of protein phosphatase 2A: interaction with other subunits and tumor antigens |journal=J. Virol. |volume=68 |issue= 1 |pages= 123–9 |year= 1994 |pmid= 8254721 |doi=  | pmc=236271  |name-list-format=vanc| author2=Hentz M  | author3=Fait J  | display-authors=3  | last4=Mumby  | first4=M  | last5=Walter  | first5=G  }}
*{{cite journal  | author=Zolnierowicz S |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits |journal=Biochem. J. |volume=317 |issue=  1|pages= 187–94 |year= 1996 |pmid= 8694763 |doi=  10.1042/bj3170187| pmc=1217462  |name-list-format=vanc| author2=Van Hoof C  | author3=Andjelković N  | display-authors=3  | last4=Cron  | first4=P  | last5=Stevens  | first5=I  | last6=Merlevede  | first6=W  | last7=Goris  | first7=J  | last8=Hemmings  | first8=BA  }}
*{{cite journal  | author=Tung HY |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr |journal=FEBS Lett. |volume=401 |issue= 2–3 |pages= 197–201 |year= 1997 |pmid= 9013886 |doi=10.1016/S0014-5793(96)01470-6  |name-list-format=vanc| author2=De Rocquigny H  | author3=Zhao LJ  | display-authors=3  | last4=Cayla  | first4=X  | last5=Roques  | first5=BP  | last6=Ozon  | first6=R  }}
*{{cite journal  |vauthors=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production |journal=Virology |volume=238 |issue= 2 |pages= 432–443 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
*{{cite journal  |vauthors=Ruediger R, Fields K, Walter G |title=Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens |journal=J. Virol. |volume=73 |issue= 1 |pages= 839–42 |year= 1999 |pmid= 9847399 |doi=  | pmc=103900  }}
*{{cite journal  | author=Groves MR |title=The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs |journal=Cell |volume=96 |issue= 1 |pages= 99–110 |year= 1999 |pmid= 9989501 |doi=10.1016/S0092-8674(00)80963-0  |name-list-format=vanc| author2=Hanlon N  | author3=Turowski P  | display-authors=3  | last4=Hemmings  | first4=Brian A.  | last5=Barford  | first5=David  }}
*{{cite journal  |vauthors=Hong Y, Sarge KD |title=Regulation of protein phosphatase 2A activity by heat shock transcription factor 2 |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12967–12970 |year= 1999 |pmid= 10224043 |doi=10.1074/jbc.274.19.12967  }}
*{{cite journal  |vauthors=Yan Z, Fedorov SA, Mumby MC, Williams RS |title=PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells |journal=Mol. Cell. Biol. |volume=20 |issue= 3 |pages= 1021–1029 |year= 2000 |pmid= 10629059 |doi=10.1128/MCB.20.3.1021-1029.2000  | pmc=85219  }}
*{{cite journal  | author=Husi H |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661–669 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615  |name-list-format=vanc| author2=Ward MA  | author3=Choudhary JS  | display-authors=3  | last4=Choudhary  | first4=Jyoti S.  | last5=Blackstock  | first5=Walter P. }}
*{{cite journal  |vauthors=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956–3967 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956  | pmc=306605 }}{{Retracted paper}}
*{{cite journal  |vauthors=Ruteshouser EC, Ashworth LK, Huff V |title=Absence of PPP2R1A mutations in Wilms tumor |journal=Oncogene |volume=20 |issue= 16 |pages= 2050–2054 |year= 2001 |pmid= 11360189 |doi= 10.1038/sj.onc.1204301 }}
*{{cite journal  |vauthors=Lubert EJ, Hong Y, Sarge KD |title=Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5 |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 38582–38587 |year= 2001 |pmid= 11504734 |doi= 10.1074/jbc.M106906200 }}
*{{cite journal  | author=Elder RT |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 |journal=Virology |volume=287 |issue= 2 |pages= 359–370 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007  |name-list-format=vanc| author2=Yu M  | author3=Chen M  | display-authors=3  | last4=Zhu  | first4=X  | last5=Yanagida  | first5=M  | last6=Zhao  | first6=Y }}
*{{cite journal  |vauthors=Li X, Virshup DM |title=Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 546–552 |year= 2002 |pmid= 11856313 |doi=10.1046/j.0014-2956.2001.02680.x  }}
}}
{{refend}}

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