View source for Parathyroid chief cell

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'''Parathyroid chief cells''' are [[cell (biology)|cells]] in the [[parathyroid gland]]s which produce [[parathyroid hormone]]. 

The end result of increased secretion by the [[chief cell]]s of a parathyroid gland is an increase in the [[blood plasma|serum]] level of [[Calcium]]. Parathyroid chief cells constitute one of the few cell types of the body that regulate intracellular calcium levels as a consequence of extracellular (or serum) changes in calcium concentration.  

The [[calcium-sensing receptor]] (CaSR) is sensitive to an increase in serum calcium, and stimulates the uptake of calcium by the parathyroid chief cell.  This mechanism is critically important, as it describes a physiological feed-back loop by which parathyroid hormone secretion is down-regulated in response to a restoration of serum calcium.

==See also==
* [[Oxyphil cell]]

==External links==
* {{BUHistology|15002loa}}
* {{USCHistology|end/c_29}}

{{Endocrine system}}

[[Category:Peptide hormone secreting cells]]
[[Category:Endocrinology]]
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