View source for RAR-related orphan receptor beta

{{Infobox_gene}}
'''RAR-related orphan receptor beta''' ('''ROR-beta'''), also known as '''NR1F2''' (nuclear receptor subfamily 1, group F, member 2) is a [[nuclear receptor]] that in humans is encoded by the ''RORB'' gene.<ref name="pmid7926749">{{cite journal | vauthors = Giguère V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G | title = Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors | journal = Genes Dev. | volume = 8 | issue = 5 | pages = 538–53  | date = March 1994 | pmid = 7926749 | doi = 10.1101/gad.8.5.538 }}</ref>

== Function ==

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to [[hormone response element]]s upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with [[NME1|NM23-2]], a [[nucleoside-diphosphate kinase]] involved in organogenesis and differentiation.<ref name="entrez">{{cite web | title = Entrez Gene: RORB RAR-related orphan receptor B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6096| accessdate = }}</ref>

In the brain, ROR-beta is concentrated in layer 4 of the cerebral cortex, where it plays a role in the development of structures such as barrel columns.<ref name="pmid21799210">{{cite journal | vauthors = Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD | title = RORβ induces barrel-like neuronal clusters in the developing neocortex | journal = Cereb. Cortex | volume = 22 | issue = 5 | pages = 996–1006  | date = May 2012 | pmid = 21799210 | pmc = 3328343 | doi = 10.1093/cercor/bhr182 }}</ref>

== Interactions ==

RAR-related orphan receptor beta has been shown to [[Protein-protein interaction|interact]] with [[NME1]].<ref name="pmid8858107">{{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7  | date = October 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}</ref>

== See also ==
* [[RAR-related orphan receptor]]

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Beeson WM, Perry TW, Zurcher TD | title = Effect of supplemental zinc on growth and on hair and blood serum levels of beef cattle | journal = J. Anim. Sci. | volume = 45 | issue = 1 | pages = 160–5 | year = 1977 | pmid = 885817 | doi =  }}
* {{cite journal | vauthors = Carlberg C, Hooft van Huijsduijnen R, Staple JK, DeLamarter JF, Becker-André M | title = RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers | journal = Mol. Endocrinol. | volume = 8 | issue = 6 | pages = 757–70 | year = 1994 | pmid = 7935491 | doi = 10.1210/me.8.6.757 }}
* {{cite journal | vauthors = Greiner EF, Kirfel J, Greschik H, Dörflinger U, Becker P, Mercep A, Schüle R | title = Functional analysis of retinoid Z receptor beta, a brain-specific nuclear orphan receptor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10105–10 | year = 1996 | pmid = 8816759 | pmc = 38344 | doi = 10.1073/pnas.93.19.10105 }}
* {{cite journal | vauthors = Paravicini G, Steinmayr M, André E, Becker-André M | title = The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily | journal = Biochem. Biophys. Res. Commun. | volume = 227 | issue = 1 | pages = 82–7 | year = 1996 | pmid = 8858107 | doi = 10.1006/bbrc.1996.1471 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Park HT, Baek SY, Kim BS, Kim JB, Kim JJ | title = Developmental expression of 'RZR beta, a putative nuclear-melatonin receptor' mRNA in the suprachiasmatic nucleus of the rat | journal = Neurosci. Lett. | volume = 217 | issue = 1 | pages = 17–20 | year = 1996 | pmid = 8905729 | doi = 10.1016/S0304-3940(96)13060-3 }}
* {{cite journal | vauthors = André E, Conquet F, Steinmayr M, Stratton SC, Porciatti V, Becker-André M | title = Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice | journal = EMBO J. | volume = 17 | issue = 14 | pages = 3867–77 | year = 1998 | pmid = 9670004 | pmc = 1170722 | doi = 10.1093/emboj/17.14.3867 }}
* {{cite journal | vauthors = Greiner EF, Kirfel J, Greschik H, Huang D, Becker P, Kapfhammer JP, Schüle R | title = Differential ligand-dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 13 | pages = 7160–5 | year = 2000 | pmid = 10860982 | pmc = 16516 | doi = 10.1073/pnas.97.13.7160 }}
* {{cite journal | vauthors = Gawlas K, Stunnenberg HG | title = Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1) | journal = Biochim. Biophys. Acta | volume = 1494 | issue = 3 | pages = 236–41 | year = 2000 | pmid = 11121580 | doi = 10.1016/s0167-4781(00)00237-2 }}
* {{cite journal | vauthors = Gawlas K, Stunnenberg HG | title = Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells | journal = Nucleic Acids Res. | volume = 29 | issue = 16 | pages = 3424–32 | year = 2001 | pmid = 11504880 | pmc = 55847 | doi = 10.1093/nar/29.16.3424 }}
* {{cite journal | vauthors = Stehlin C, Wurtz JM, Steinmetz A, Greiner E, Schüle R, Moras D, Renaud JP | title = X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation | journal = EMBO J. | volume = 20 | issue = 21 | pages = 5822–31 | year = 2001 | pmid = 11689423 | pmc = 125710 | doi = 10.1093/emboj/20.21.5822 }}
* {{cite journal | vauthors = Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H | title = Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus | journal = Neurosci. Lett. | volume = 320 | issue = 1-2 | pages = 13–6 | year = 2002 | pmid = 11849752 | doi = 10.1016/S0304-3940(02)00011-3 }}
* {{cite journal | vauthors = Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R | title = All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta | journal = Nat. Struct. Biol. | volume = 10 | issue = 10 | pages = 820–5 | year = 2003 | pmid = 12958591 | doi = 10.1038/nsb979 }}
{{refend}}

== External links ==
* {{MeshName|orphan+nuclear+receptor+ROR-beta}}

{{PDB Gallery|geneid=6096}}
{{Transcription factors|g2}}
{{Nuclear receptor ligands}}

[[Category:Intracellular receptors]]
[[Category:Transcription factors]]


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