View source for REPS2

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{{Infobox_gene}}
'''RalBP1-associated Eps domain-containing protein 2''' is a [[protein]] that in humans is encoded by the ''REPS2'' [[gene]].<ref name="pmid9422736">{{cite journal | vauthors = Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A | title = Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral | journal = J Biol Chem | volume = 273 | issue = 2 | pages = 814–21 | date = Feb 1998 | pmid = 9422736 | pmc =  | doi = 10.1074/jbc.273.2.814 }}</ref><ref name="pmid9928989">{{cite journal | vauthors = Koshiba S, Kigawa T, Iwahara J, Kikuchi A, Yokoyama S | title = Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1) | journal = FEBS Lett | volume = 442 | issue = 2–3 | pages = 138–42 | date = Feb 1999 | pmid = 9928989 | pmc =  | doi = 10.1016/S0014-5793(98)01644-5 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9185| accessdate = }}</ref>

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== Function ==

The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" />

== Interactions ==
REPS2 has been shown to [[Protein-protein interaction|interact]] with [[EPN1]],<ref name=pmid10557078>{{cite journal | vauthors = Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A | title = Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis | language =  | journal = Oncogene | volume = 18 | issue = 43 | pages = 5915–22 | date = Oct 1999 | pmid = 10557078 | doi = 10.1038/sj.onc.1202974  }}</ref> [[EPS15]]<ref name=pmid10393179>{{cite journal | vauthors = Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A | title = Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors | language =  | journal = EMBO J. | volume = 18 | issue = 13 | pages = 3629–42 | date = Jul 1999 | pmid = 10393179 | pmc = 1171441 | doi = 10.1093/emboj/18.13.3629 }}</ref> and [[RALBP1]].<ref name=pmid9422736 />
== References ==
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== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A | title = Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors | journal = EMBO J. | volume = 18 | issue = 13 | pages = 3629–42 | year = 1999 | pmid = 10393179 | pmc = 1171441 | doi = 10.1093/emboj/18.13.3629 }}
* {{cite journal | vauthors = Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A | title = Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis | journal = Oncogene | volume = 18 | issue = 43 | pages = 5915–22 | year = 1999 | pmid = 10557078 | doi = 10.1038/sj.onc.1202974 }}
* {{cite journal | vauthors = Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H | title = Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19008–18 | year = 2002 | pmid = 11882656 | doi = 10.1074/jbc.M112472200 }}
* {{cite journal | vauthors = Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A | title = Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration | journal = J. Biol. Chem. | volume = 277 | issue = 41 | pages = 38618–26 | year = 2002 | pmid = 12149250 | doi = 10.1074/jbc.M203453200 }}
* {{cite journal | vauthors = Oosterhoff JK, Penninkhof F, Brinkmann AO, Anton Grootegoed J, Blok LJ | title = REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells | journal = Oncogene | volume = 22 | issue = 19 | pages = 2920–5 | year = 2003 | pmid = 12771942 | doi = 10.1038/sj.onc.1206397 }}
* {{cite journal | vauthors = Rossé C, L'Hoste S, Offner N, Picard A, Camonis J | title = RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis | journal = J. Biol. Chem. | volume = 278 | issue = 33 | pages = 30597–604 | year = 2003 | pmid = 12775724 | doi = 10.1074/jbc.M302191200 }}
* {{cite journal | vauthors = Penninkhof F, Grootegoed JA, Blok LJ | title = Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells | journal = Oncogene | volume = 23 | issue = 33 | pages = 5607–15 | year = 2004 | pmid = 15184881 | doi = 10.1038/sj.onc.1207750 }}
* {{cite journal | vauthors = Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ | title = EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2 | journal = Int. J. Cancer | volume = 113 | issue = 4 | pages = 561–7 | year = 2005 | pmid = 15455380 | doi = 10.1002/ijc.20612 }}
* {{cite journal | vauthors = Yadav S, Zajac E, Singhal SS, Singhal J, Drake K, Awasthi YC, Awasthi S | title = POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 328 | issue = 4 | pages = 1003–9 | year = 2005 | pmid = 15707977 | doi = 10.1016/j.bbrc.2005.01.055 }}
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[[Category:EH-domain-containing proteins]]