View source for Replication protein A1

{{Infobox_gene}}
'''Replication protein A 70 kDa DNA-binding subunit''' is a [[protein]] that in humans is encoded by the ''RPA1'' [[gene]].<ref name="pmid8454588">{{cite journal | vauthors = Umbricht CB, Erdile LF, Jabs EW, Kelly TJ | author-link4 = Thomas J. Kelly (scientist) | title = Cloning, overexpression, and genomic mapping of the 14-kDa subunit of human replication protein A | journal = J Biol Chem | volume = 268 | issue = 9 | pages = 6131–8 | date = April 1993 | pmid = 8454588 | pmc =  | doi =  }}</ref>

== Interactions ==
Replication protein A1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[BRCA2]],<ref name = pmid12527904>{{cite journal | vauthors = Wong JM, Ionescu D, Ingles CJ | title = Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2 | journal = Oncogene | volume = 22 | issue = 1 | pages = 28–33 | date = January 2003 | pmid = 12527904 | doi = 10.1038/sj.onc.1206071 }}</ref> 
* [[Bloom syndrome protein|BLM]],<ref name = pmid10825162>{{cite journal | vauthors = Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, Hickson ID, Bohr VA | title = Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23500–8 | date = August 2000 | pmid = 10825162 | doi = 10.1074/jbc.M001557200 }}</ref><ref name = pmid12181313>{{cite journal | vauthors = Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA | title = Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 41110–9 | date = October 2002 | pmid = 12181313 | doi = 10.1074/jbc.M205396200 }}</ref><ref name = pmid11950880>{{cite journal | vauthors = Moens PB, Kolas NK, Tarsounas M, Marcon E, Cohen PE, Spyropoulos B | title = The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination | journal = J. Cell Sci. | volume = 115 | issue = Pt 8 | pages = 1611–22 | date = April 2002 | pmid = 11950880 | doi =  }}</ref>
* [[MCM2]],<ref name = pmid12614612/> 
* [[MCM4]],<ref name = pmid12614612/> 
* [[MCM6]],<ref name = pmid12614612>{{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = J. Mol. Biol. | volume = 327 | issue = 1 | pages = 111–28 | date = March 2003 | pmid = 12614612 | doi =  10.1016/s0022-2836(03)00079-2}}</ref> 
* [[MCM7]],<ref name = pmid12614612/> 
* [[MUTYH]],<ref name = pmid11092888>{{cite journal | vauthors = Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL | title = Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5547–55 | date = February 2001 | pmid = 11092888 | doi = 10.1074/jbc.M008463200 }}</ref> 
* [[ORC2L]],<ref name = pmid12614612/> 
* [[ORC6L]],<ref name = pmid12614612/> 
* [[P53]],<ref name = pmid15489903>{{cite journal | vauthors = Romanova LY, Willers H, Blagosklonny MV, Powell SN | title = The interaction of p53 with replication protein A mediates suppression of homologous recombination | journal = Oncogene | volume = 23 | issue = 56 | pages = 9025–33 | date = Dec 2004 | pmid = 15489903 | doi = 10.1038/sj.onc.1207982 }}</ref><ref name = pmid11751427>{{cite journal | vauthors = Riva F, Zuco V, Vink AA, Supino R, Prosperi E | title = UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication protein A interaction in p53 wild type and mutant ovarian carcinoma cells | journal = Carcinogenesis | volume = 22 | issue = 12 | pages = 1971–8 | date = Dec 2001 | pmid = 11751427 | doi =  10.1093/carcin/22.12.1971}}</ref> 
* [[RPA2]],<ref name = pmid10064605>{{cite journal | vauthors = Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y | title = Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes | journal = EMBO J. | volume = 18 | issue = 5 | pages = 1397–406 | date = March 1999 | pmid = 10064605 | pmc = 1171229 | doi = 10.1093/emboj/18.5.1397 }}</ref><ref name = pmid11927569>{{cite journal | vauthors = Bochkareva E, Korolev S, Lees-Miller SP, Bochkarev A | title = Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA | journal = EMBO J. | volume = 21 | issue = 7 | pages = 1855–63 | date = April 2002 | pmid = 11927569 | pmc = 125950 | doi = 10.1093/emboj/21.7.1855 }}</ref> 
* [[RPA3]],<ref name = pmid11927569/><ref name = pmid9461578>{{cite journal | vauthors = Bochkareva E, Frappier L, Edwards AM, Bochkarev A | title = The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain | journal = J. Biol. Chem. | volume = 273 | issue = 7 | pages = 3932–6 | date = February 1998 | pmid = 9461578 | doi =  10.1074/jbc.273.7.3932}}</ref> 
* [[TIPIN]],<ref name = pmid17296725>{{cite journal | vauthors = Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK | title = The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement | journal = Mol. Cell. Biol. | volume = 27 | issue = 8 | pages = 3131–42 | date = April 2007 | pmid = 17296725 | pmc = 1899931 | doi = 10.1128/MCB.02190-06 }}</ref> 
* [[TP53BP1]],<ref name = pmid15856006>{{cite journal | vauthors = Yoo E, Kim BU, Lee SY, Cho CH, Chung JH, Lee CH | title = 53BP1 is associated with replication protein A and is required for RPA2 hyperphosphorylation following DNA damage | journal = Oncogene | volume = 24 | issue = 35 | pages = 5423–30 | date = August 2005 | pmid = 15856006 | doi = 10.1038/sj.onc.1208710 }}</ref>  and
* [[XPA]].<ref name = pmid7565690>{{cite journal | vauthors = Li L, Lu X, Peterson CA, Legerski RJ | title = An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair | journal = Mol. Cell. Biol. | volume = 15 | issue = 10 | pages = 5396–402 | date = October 1995 | pmid = 7565690 | pmc = 230789 | doi =  10.1128/mcb.15.10.5396}}</ref> 
{{Div col end}}

==See also==
* [[Replication protein A]]
* [[Replication protein A2]]
* [[Replication protein A3]]
* [[Single-stranded binding protein]]

== References ==
{{Reflist|35em}}

== Further reading ==
{{Refbegin|35em}}
* {{cite journal | vauthors = Iftode C, Daniely Y, Borowiec JA | title = Replication protein A (RPA): the eukaryotic SSB. | journal = Crit. Rev. Biochem. Mol. Biol. | volume = 34 | issue = 3 | pages = 141–80 | year = 1999 | pmid = 10473346 | doi = 10.1080/10409239991209255 }}
* {{cite journal | vauthors = Binz SK, Sheehan AM, Wold MS | title = Replication protein A phosphorylation and the cellular response to DNA damage. | journal = DNA Repair (Amst.) | volume = 3 | issue = 8-9 | pages = 1015–24 | year = 2005 | pmid = 15279788 | doi = 10.1016/j.dnarep.2004.03.028 }}
* {{cite journal | vauthors = Dornreiter I, Erdile LF, Gilbert IU, von Winkler D, Kelly TJ, Fanning E | title = Interaction of DNA polymerase alpha-primase with cellular replication protein A and SV40 T antigen. | journal = EMBO J. | volume = 11 | issue = 2 | pages = 769–76 | year = 1992 | pmid = 1311258 | pmc = 556510 | doi =  }}
* {{cite journal | vauthors = Erdile LF, Heyer WD, Kolodner R, Kelly TJ | title = Characterization of a cDNA encoding the 70-kDa single-stranded DNA-binding subunit of human replication protein A and the role of the protein in DNA replication. | journal = J. Biol. Chem. | volume = 266 | issue = 18 | pages = 12090–8 | year = 1991 | pmid = 2050703 | doi =  }}
* {{cite journal | vauthors = Li L, Lu X, Peterson CA, Legerski RJ | title = An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair. | journal = Mol. Cell. Biol. | volume = 15 | issue = 10 | pages = 5396–402 | year = 1995 | pmid = 7565690 | pmc = 230789 | doi =  10.1128/mcb.15.10.5396}}
* {{cite journal | vauthors = Keshav KF, Chen C, Dutta A | title = Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex. | journal = Mol. Cell. Biol. | volume = 15 | issue = 6 | pages = 3119–28 | year = 1995 | pmid = 7760808 | pmc = 230543 | doi =  10.1128/mcb.15.6.3119}}
* {{cite journal | vauthors = Umbricht CB, Griffin CA, Hawkins AL, Grzeschik KH, O'Connell P, Leach R, Green ED, Kelly TJ | title = High-resolution genomic mapping of the three human replication protein A genes (RPA1, RPA2, and RPA3). | journal = Genomics | volume = 20 | issue = 2 | pages = 249–57 | year = 1994 | pmid = 8020972 | doi = 10.1006/geno.1994.1161 }}
* {{cite journal | vauthors = Gomes XV, Wold MS | title = Functional domains of the 70-kilodalton subunit of human replication protein A. | journal = Biochemistry | volume = 35 | issue = 32 | pages = 10558–68 | year = 1996 | pmid = 8756712 | doi = 10.1021/bi9607517 }}
* {{cite journal | vauthors = Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L | title = Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. | journal = Nature | volume = 385 | issue = 6612 | pages = 176–81 | year = 1997 | pmid = 8990123 | doi = 10.1038/385176a0 }}
* {{cite journal | vauthors = Amacker M, Hottiger M, Mossi R, Hübscher U | title = HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase. | journal = AIDS | volume = 11 | issue = 4 | pages = 534–6 | year = 1997 | pmid = 9084803 | doi =  }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1817–23 | year = 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
* {{cite journal | vauthors = Loor G, Zhang SJ, Zhang P, Toomey NL, Lee MY | title = Identification of DNA replication and cell cycle proteins that interact with PCNA. | journal = Nucleic Acids Res. | volume = 25 | issue = 24 | pages = 5041–6 | year = 1998 | pmid = 9396813 | pmc = 147130 | doi = 10.1093/nar/25.24.5041 }}
* {{cite journal | vauthors = Bochkareva E, Frappier L, Edwards AM, Bochkarev A | title = The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain. | journal = J. Biol. Chem. | volume = 273 | issue = 7 | pages = 3932–6 | year = 1998 | pmid = 9461578 | doi = 10.1074/jbc.273.7.3932 }}
* {{cite journal | vauthors = Golub EI, Gupta RC, Haaf T, Wold MS, Radding CM | title = Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA. | journal = Nucleic Acids Res. | volume = 26 | issue = 23 | pages = 5388–93 | year = 1999 | pmid = 9826763 | pmc = 148005 | doi = 10.1093/nar/26.23.5388 }}
* {{cite journal | vauthors = Shao RG, Cao CX, Zhang H, Kohn KW, Wold MS, Pommier Y | title = Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. | journal = EMBO J. | volume = 18 | issue = 5 | pages = 1397–406 | year = 1999 | pmid = 10064605 | pmc = 1171229 | doi = 10.1093/emboj/18.5.1397 }}
* {{cite journal | vauthors = Brosh RM, Orren DK, Nehlin JO, Ravn PH, Kenny MK, Machwe A, Bohr VA | title = Functional and physical interaction between WRN helicase and human replication protein A. | journal = J. Biol. Chem. | volume = 274 | issue = 26 | pages = 18341–50 | year = 1999 | pmid = 10373438 | doi = 10.1074/jbc.274.26.18341 }}
* {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members. | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | year = 2000 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
* {{cite journal | vauthors = Brosh RM, Li JL, Kenny MK, Karow JK, Cooper MP, Kureekattil RP, Hickson ID, Bohr VA | title = Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity. | journal = J. Biol. Chem. | volume = 275 | issue = 31 | pages = 23500–8 | year = 2000 | pmid = 10825162 | doi = 10.1074/jbc.M001557200 }}
{{Refend}}

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{{DNA replication}}