View source for SDHC

{{protein
| Name = succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
| caption = 
| image=SuccDeh.svg 
| width=250
| HGNCid = 10682
| Symbol = SDHC
| AltSymbols = PGL3
| EntrezGene = 6391
| OMIM = 602413
| RefSeq = NM_003001
| UniProt = Q99643
| PDB = 
| ECnumber = 
| Chromosome = 1
| Arm = q
| Band = 21
| LocusSupplementaryData = 
}}


'''SDHC''' is an abbrevation for '''succinate dehydrogenase complex subunit C'''.

The term SDHC can  refer to;

*  The protein subunit itself.
*  The gene that codes for this protein.

The [[succinate dehydrogenase]] (SDH) protein complex catalyzes  the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The [[SDHA]] subunit is connected to the [[SDHB]] subunit on the hydrophilic, catalytic end of the complex. Electrons removed from succinate transfer SDHA, to SDHB and further to the '''SDHC'''/[[SDHD]] subunits on the hydrophobic end of the complex anchored in the mitochondrial membrane. 

==Function of the SDHC protein==

The SDH complex is located on the inner membrane of the [[mitochondria]] and participates in both the [[Citric Acid Cycle]] and [[Respiratory chain]].

SDHC acts as an intermediate in the basic SDH enzyme action:
# [[SDHA]] converts [[succinate]] to [[fumarate]] as part of the [[Citric Acid Cycle]]. This reaction also converts [[FAD]] to [[Flavin|FADH<sub>2</sub>]].
# Electrons from the FADH<sub>2</sub> are transferred to the SDHB subunit iron clusters [2Fe-2S],[4Fe-4S],[3Fe-4S]. This function is part of the [[Respiratory chain]]
# '''Finally the electrons are transferred to the [[Ubiquinone]] (Q) pool via the SDHC/[[SDHD]] subunits'''.

==Gene that codes for SDHC== 
The gene that codes for the SDHC protein is nuclear, even though the protein is located in the inner membrane of the [[mitochondria]]. The location of the gene in humans is on the [[Chromosome 1 (human)|first chromosome]] at q21. The [[gene]] is  partitioned in 6 [[exon]]s.
The expressed protein has 170 amino acids.

SDHC was previously called '''PGL3'''.

{{Citric acid cycle enzymes}}
[[Category:Genes]]

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