View source for SIN3B

{{Infobox_gene}}
'''Paired amphipathic helix protein Sin3b''' is a [[protein]] that in humans is encoded by the ''SIN3B'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | pmc =  | doi = 10.1093/dnares/5.3.169 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>

== Interactions ==

SIN3B has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid10444591>{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}</ref><ref name=pmid10357820>{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}</ref> [[Zinc finger and BTB domain-containing protein 16]],<ref name=pmid9627120>{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}</ref> [[SUDS3]]<ref name=pmid11909966>{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}</ref> and [[IKZF1]].<ref name=pmid10357820/><ref name=pmid12015313>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}</ref>

== See also ==
* [[Transcription coregulator]]

== References ==
{{reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Ayer DE, Lawrence QA, Eisenman RN | title = Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 | journal = Cell | volume = 80 | issue = 5 | pages = 767–76 | date = Mar 1995 | pmid = 7889570 | doi = 10.1016/0092-8674(95)90355-0 }}
* {{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}
* {{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}
* {{cite journal | vauthors = Naruse Y, Aoki T, Kojima T, Mori N | title = Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 24 | pages = 13691–6 | date = Nov 1999 | pmid = 10570134 | pmc = 24126 | doi = 10.1073/pnas.96.24.13691 }}
* {{cite journal | vauthors = Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW | title = The Mad1-Sin3B interaction involves a novel helical fold | journal = Nature Structural Biology | volume = 7 | issue = 12 | pages = 1100–4 | date = Dec 2000 | pmid = 11101889 | doi = 10.1038/81944 }}
* {{cite journal | vauthors = Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW | title = Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1 | journal = Journal of Biomolecular NMR | volume = 19 | issue = 4 | pages = 377–8 | date = Apr 2001 | pmid = 11370785 | doi = 10.1023/A:1011262214741 }}
* {{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}
* {{cite journal | vauthors = Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD | title = E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex | journal = Genes & Development | volume = 16 | issue = 8 | pages = 933–47 | date = Apr 2002 | pmid = 11959842 | pmc = 152357 | doi = 10.1101/gad.969202 }}
* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}
* {{cite journal | vauthors = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 651–7 | date = Feb 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854 }}
* {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}
* {{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = Apr 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
* {{cite journal | vauthors = Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N | title = Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential | journal = Oncogene | volume = 23 | issue = 55 | pages = 8887–99 | date = Nov 2004 | pmid = 15467743 | doi = 10.1038/sj.onc.1208107 }}
* {{cite journal | vauthors = Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S | title = Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex | journal = Molecular and Cellular Biology | volume = 25 | issue = 19 | pages = 8415–29 | date = Oct 2005 | pmid = 16166625 | pmc = 1265755 | doi = 10.1128/MCB.25.19.8415-8429.2005 }}
* {{cite journal | vauthors = Xu Y, Sengupta PK, Seto E, Smith BD | title = Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression | journal = The Journal of Biological Chemistry | volume = 281 | issue = 14 | pages = 9260–70 | date = Apr 2006 | pmid = 16464847 | pmc = 1434794 | doi = 10.1074/jbc.M511724200 }}
{{refend}}
{{PDB Gallery|geneid=23309}}

== External links ==
* {{MeshName|SIN3B+protein,+human}}

{{NLM content}}
{{Transcription coregulators}}

[[Category:Gene expression]]
[[Category:Transcription coregulators]]


{{gene-19-stub}}