View source for SLC15A1

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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Solute carrier family 15 (oligopeptide transporter), member 1
 | HGNCid = 10920
 | Symbol = SLC15A1
 | AltSymbols =; HPECT1; HPEPT1; PEPT1
 | OMIM = 600544
 | ECnumber =  
 | Homologene = 38006
 | MGIid = 1861376
 | GeneAtlas_image1 = PBB_GE_SLC15A1_207254_at_tn.png
 | GeneAtlas_image2 = PBB_GE_SLC15A1_211349_at_tn.png
 | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015333 |text = peptide:hydrogen symporter activity}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006857 |text = oligopeptide transport}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0015031 |text = protein transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6564
    | Hs_Ensembl = ENSG00000088386
    | Hs_RefseqProtein = NP_005064
    | Hs_RefseqmRNA = NM_005073
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 98134056
    | Hs_GenLoc_end = 98202908
    | Hs_Uniprot = P46059
    | Mm_EntrezGene = 56643
    | Mm_Ensembl = ENSMUSG00000025557
    | Mm_RefseqmRNA = NM_053079
    | Mm_RefseqProtein = NP_444309
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 120595762
    | Mm_GenLoc_end = 120626569
    | Mm_Uniprot = Q14BA3
  }}
}}
'''Solute carrier family 15 (oligopeptide transporter), member 1''', also known as '''SLC15A1''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6564| accessdate = }}</ref>

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{{PBB_Summary
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==References==
{{reflist|2}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Adibi SA |title=The oligopeptide transporter (Pept-1) in human intestine: biology and function. |journal=Gastroenterology |volume=113 |issue= 1 |pages= 332-40 |year= 1997 |pmid= 9207295 |doi=  }}
*{{cite journal  | author=Adibi SA |title=Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=285 |issue= 5 |pages= G779-88 |year= 2003 |pmid= 14561585 |doi= 10.1152/ajpgi.00056.2003 }}
*{{cite journal  | author=Ganapathy ME, Brandsch M, Prasad PD, ''et al.'' |title=Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. |journal=J. Biol. Chem. |volume=270 |issue= 43 |pages= 25672-7 |year= 1995 |pmid= 7592745 |doi=  }}
*{{cite journal  | author=Liang R, Fei YJ, Prasad PD, ''et al.'' |title=Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. |journal=J. Biol. Chem. |volume=270 |issue= 12 |pages= 6456-63 |year= 1995 |pmid= 7896779 |doi=  }}
*{{cite journal  | author=Thamotharan M, Lombardo YB, Bawani SZ, Adibi SA |title=An active mechanism for completion of the final stage of protein degradation in the liver, lysosomal transport of dipeptides. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11786-90 |year= 1997 |pmid= 9115234 |doi=  }}
*{{cite journal  | author=Saito H, Motohashi H, Mukai M, Inui K |title=Cloning and characterization of a pH-sensing regulatory factor that modulates transport activity of the human H+/peptide cotransporter, PEPT1. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 3 |pages= 577-82 |year= 1997 |pmid= 9299407 |doi=  }}
*{{cite journal  | author=Gonzalez DE, Covitz KM, Sadée W, Mrsny RJ |title=An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. |journal=Cancer Res. |volume=58 |issue= 3 |pages= 519-25 |year= 1998 |pmid= 9458100 |doi=  }}
*{{cite journal  | author=Walker D, Thwaites DT, Simmons NL, ''et al.'' |title=Substrate upregulation of the human small intestinal peptide transporter, hPepT1. |journal=J. Physiol. (Lond.) |volume=507 ( Pt 3) |issue=  |pages= 697-706 |year= 1998 |pmid= 9508831 |doi=  }}
*{{cite journal  | author=Ashida K, Katsura T, Motohashi H, ''et al.'' |title=Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=282 |issue= 4 |pages= G617-23 |year= 2002 |pmid= 11897620 |doi= 10.1152/ajpgi.00344.2001 }}
*{{cite journal  | author=Döring F, Martini C, Walter J, Daniel H |title=Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function. |journal=J. Membr. Biol. |volume=186 |issue= 2 |pages= 55-62 |year= 2002 |pmid= 11944083 |doi= 10.1007/s00232-001-0135-9 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ford D, Howard A, Hirst BH |title=Expression of the peptide transporter hPepT1 in human colon: a potential route for colonic protein nitrogen and drug absorption. |journal=Histochem. Cell Biol. |volume=119 |issue= 1 |pages= 37-43 |year= 2003 |pmid= 12548404 |doi= 10.1007/s00418-002-0479-y }}
*{{cite journal  | author=Neumann J, Brandsch M |title=Delta-aminolevulinic acid transport in cancer cells of the human extrahepatic biliary duct. |journal=J. Pharmacol. Exp. Ther. |volume=305 |issue= 1 |pages= 219-24 |year= 2003 |pmid= 12649372 |doi= 10.1124/jpet.102.046573 }}
*{{cite journal  | author=Sun BW, Zhao XC, Wang GJ, ''et al.'' |title=Hormonal regulation of dipeptide transporter (PepT1) in Caco-2 cells with normal and anoxia/reoxygenation management. |journal=World J. Gastroenterol. |volume=9 |issue= 4 |pages= 808-12 |year= 2003 |pmid= 12679938 |doi=  }}
*{{cite journal  | author=Kulkarni AA, Haworth IS, Lee VH |title=Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 177-85 |year= 2003 |pmid= 12788085 |doi=  }}
*{{cite journal  | author=Kulkarni AA, Haworth IS, Uchiyama T, Lee VH |title=Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51833-40 |year= 2004 |pmid= 14532279 |doi= 10.1074/jbc.M308356200 }}
*{{cite journal  | author=Uchiyama T, Kulkarni AA, Davies DL, Lee VH |title=Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1. |journal=Pharm. Res. |volume=20 |issue= 12 |pages= 1911-6 |year= 2004 |pmid= 14725353 |doi=  }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
}}
{{refend}}

{{Membrane transport proteins}}
[[Category:Membrane biology]]
[[Category:Integral membrane proteins]]
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