View source for SLC25A4

{{Use dmy dates|date=May 2013}}
{{Infobox_gene}}
'''ADP/ATP translocase 1''' is an [[enzyme]] that in humans is encoded by the ''SLC25A4'' [[gene]] or adenine nucleotide translocator, ANT.<ref name="pmid1582253">{{cite journal | vauthors = Fan YS, Yang HM, Lin CC | title = Assignment of the human muscle adenine nucleotide translocator gene (ANT1) to 4q35 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 60 | issue = 1 | pages = 29–30 | date = Jun 1992 | pmid = 1582253 | pmc =  | doi = 10.1159/000133288 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=291| accessdate = }}</ref>

== Interactions ==

SLC25A4 has been shown to [[Protein-protein interaction|interact]] with [[Bcl-2-associated X protein]].<ref name=pmid9748162>{{cite journal | vauthors = Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G | title = Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis | journal = Science | volume = 281 | issue = 5385 | pages = 2027–31 | date = Sep 1998 | pmid = 9748162 | doi = 10.1126/science.281.5385.2027 }}</ref>

== References ==
{{Reflist}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Vieira HL, Haouzi D, El Hamel C, Jacotot E, Belzacq AS, Brenner C, Kroemer G | title = Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator | journal = Cell Death and Differentiation | volume = 7 | issue = 12 | pages = 1146–54 | date = Dec 2000 | pmid = 11175251 | doi = 10.1038/sj.cdd.4400778 }}
* {{cite journal | vauthors = Ferri KF, Jacotot E, Blanco J, Esté JA, Kroemer G | title = Mitochondrial control of cell death induced by HIV-1-encoded proteins | journal = Annals of the New York Academy of Sciences | volume = 926 | issue =  | pages = 149–64 | year = 2001 | pmid = 11193032 | doi = 10.1111/j.1749-6632.2000.tb05609.x }}
* {{cite journal | vauthors = Kino T, Pavlakis GN | title = Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1 | journal = DNA and Cell Biology | volume = 23 | issue = 4 | pages = 193–205 | date = Apr 2004 | pmid = 15142377 | doi = 10.1089/104454904773819789 }}
* {{cite journal | vauthors = Andersen JL, Planelles V | title = The role of Vpr in HIV-1 pathogenesis | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 43–51 | date = Jan 2005 | pmid = 15638722 | doi = 10.2174/1570162052772988 }}
* {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue =  | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}
* {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi =  }}
* {{cite journal | vauthors = Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB | title = Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism | journal = Cell Death and Differentiation | volume = 12 Suppl 1 | issue =  | pages = 962–70 | date = Aug 2005 | pmid = 15832179 | doi = 10.1038/sj.cdd.4401583 }}
* {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Research | volume = 15 | issue = 11-12 | pages = 923–34 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 }}
* {{cite journal | vauthors = Moon HS, Yang JS | title = Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells | journal = Molecules and Cells | volume = 21 | issue = 1 | pages = 7–20 | date = Feb 2006 | pmid = 16511342 | doi =  }}
* {{cite journal | vauthors = Cozens AL, Runswick MJ, Walker JE | title = DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase | journal = Journal of Molecular Biology | volume = 206 | issue = 2 | pages = 261–80 | date = Mar 1989 | pmid = 2541251 | doi = 10.1016/0022-2836(89)90477-4 }}
* {{cite journal | vauthors = Li K, Warner CK, Hodge JA, Minoshima S, Kudoh J, Fukuyama R, Maekawa M, Shimizu Y, Shimizu N, Wallace DC | title = A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed | journal = The Journal of Biological Chemistry | volume = 264 | issue = 24 | pages = 13998–4004 | date = Aug 1989 | pmid = 2547778 | doi =  }}
* {{cite journal | vauthors = Neckelmann N, Li K, Wade RP, Shuster R, Wallace DC | title = cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 21 | pages = 7580–4 | date = Nov 1987 | pmid = 2823266 | pmc = 299343 | doi = 10.1073/pnas.84.21.7580 }}
* {{cite journal | vauthors = Houldsworth J, Attardi G | title = Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 2 | pages = 377–81 | date = Jan 1988 | pmid = 2829183 | pmc = 279551 | doi = 10.1073/pnas.85.2.377 }}
* {{cite journal | vauthors = Wijmenga C, Winokur ST, Padberg GW, Skraastad MI, Altherr MR, Wasmuth JJ, Murray JC, Hofker MH, Frants RR | title = The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus | journal = Human Genetics | volume = 92 | issue = 2 | pages = 198–203 | date = Sep 1993 | pmid = 8103757 | doi = 10.1007/BF00219692 }}
* {{cite journal | vauthors = Bakker HD, Scholte HR, Van den Bogert C, Ruitenbeek W, Jeneson JA, Wanders RJ, Abeling NG, Dorland B, Sengers RC, Van Gennip AH | title = Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect | journal = Pediatric Research | volume = 33 | issue = 4 Pt 1 | pages = 412–7 | date = Apr 1993 | pmid = 8479824 | doi = 10.1203/00006450-199304000-00019 }}
* {{cite journal | vauthors = Kaukonen JA, Amati P, Suomalainen A, Rötig A, Piscaglia MG, Salvi F, Weissenbach J, Fratta G, Comi G, Peltonen L, Zeviani M | title = An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p | journal = American Journal of Human Genetics | volume = 58 | issue = 4 | pages = 763–9 | date = Apr 1996 | pmid = 8644740 | pmc = 1914672 | doi =  }}
* {{cite journal | vauthors = Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G | title = Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis | journal = Science | volume = 281 | issue = 5385 | pages = 2027–31 | date = Sep 1998 | pmid = 9748162 | doi = 10.1126/science.281.5385.2027 }}
* {{cite journal | vauthors = Kaukonen J, Zeviani M, Comi GP, Piscaglia MG, Peltonen L, Suomalainen A | title = A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia | journal = American Journal of Human Genetics | volume = 65 | issue = 1 | pages = 256–61 | date = Jul 1999 | pmid = 10364542 | pmc = 1378100 | doi = 10.1086/302445 }}
* {{cite journal | vauthors = Jacotot E, Ravagnan L, Loeffler M, Ferri KF, Vieira HL, Zamzami N, Costantini P, Druillennec S, Hoebeke J, Briand JP, Irinopoulou T, Daugas E, Susin SA, Cointe D, Xie ZH, Reed JC, Roques BP, Kroemer G | title = The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore | journal = The Journal of Experimental Medicine | volume = 191 | issue = 1 | pages = 33–46 | date = Jan 2000 | pmid = 10620603 | pmc = 2195797 | doi = 10.1084/jem.191.1.33 }}
{{refend}}

== External links ==
* {{MeshName|SLC25A4+protein,+human}}

{{PDB Gallery|geneid=291}}
{{Membrane transport proteins}}

[[Category:Solute carrier family]]


{{membrane-protein-stub}}