View source for SLC5A8

{{Infobox_gene}}
'''Sodium-coupled monocarboxylate transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC5A8'' [[gene]].<ref name="pmid12107270">{{cite journal | vauthors = Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T | title = Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes | journal = J Clin Endocrinol Metab | volume = 87 | issue = 7 | pages = 3500–3 |date=Jul 2002 | pmid = 12107270 | pmc =  | doi =10.1210/jc.87.7.3500  }}</ref><ref name="pmid12829793">{{cite journal | vauthors = Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD | title = SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 14 | pages = 8412–7 |date=Jul 2003 | pmid = 12829793 | pmc = 166243 | doi = 10.1073/pnas.1430846100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=160728| accessdate = }}</ref>

==See also==
* [[Solute carrier family]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | vauthors=Gupta N, Martin PM, Prasad PD, Ganapathy V |title=SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter |journal=Life Sci. |volume=78 |issue= 21 |pages= 2419–25 |year= 2006 |pmid= 16375929 |doi= 10.1016/j.lfs.2005.10.028 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | vauthors=Miyauchi S, Gopal E, Fei YJ, Ganapathy V |title=Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13293–6 |year= 2004 |pmid= 14966140 |doi= 10.1074/jbc.C400059200 }}
*{{cite journal   |vauthors=Lacroix L, Pourcher T, Magnon C, etal |title=Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 3 |pages= 1423–8 |year= 2004 |pmid= 15001644 |doi=10.1210/jc.2003-030542  }}
*{{cite journal   |vauthors=Hong C, Maunakea A, Jun P, etal |title=Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8 |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3617–23 |year= 2005 |pmid= 15867356 |doi= 10.1158/0008-5472.CAN-05-0048 }}
*{{cite journal   |vauthors=Paroder V, Spencer SR, Paroder M, etal |title=Na+/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: Molecular characterization of SMCT |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 19 |pages= 7270–5 |year= 2006 |pmid= 16670197 |doi= 10.1073/pnas.0602365103  | pmc=1456061 }}
*{{cite journal   |vauthors=Hu S, Liu D, Tufano RP, etal |title=Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer |journal=Int. J. Cancer |volume=119 |issue= 10 |pages= 2322–9 |year= 2006 |pmid= 16858683 |doi= 10.1002/ijc.22110 }}
*{{cite journal   |vauthors=Gopal E, Miyauchi S, Martin PM, etal |title=Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract |journal=Pharm. Res. |volume=24 |issue= 3 |pages= 575–84 |year= 2007 |pmid= 17245649 |doi= 10.1007/s11095-006-9176-1 }}
*{{cite journal   |vauthors=Coady MJ, Wallendorff B, Bourgeois F, etal |title=Establishing a Definitive Stoichiometry for the Na+/Monocarboxylate Cotransporter SMCT1 |journal=Biophys. J. |volume=93 |issue= 7 |pages= 2325–31 |year= 2007 |pmid= 17526579 |doi= 10.1529/biophysj.107.108555  | pmc=1965447 }}
{{refend}}

{{Solute carrier family|bg|bg0}}

[[Category:Solute carrier family]]


{{membrane-protein-stub}}