View source for SOX2

{{Infobox_gene}}
'''SRY (sex determining region Y)-box 2''', also known as '''SOX2''', is a [[transcription factor]] that is essential for maintaining self-renewal, or [[pluripotency]], of undifferentiated [[embryonic stem cell]]s. Sox2 has a critical role in maintenance of embryonic and [[neural]] stem cells.<ref name=":0">{{Cite web|url = https://www.ncbi.nlm.nih.gov/gene/6657|title = SOX2|date = |accessdate = |website = |publisher = NCBI}}</ref>

Sox2 is a member of the Sox [[Family (biology)|family]] of [[transcription factors]], which have been shown to play key roles in many stages of [[mammal]]ian development. This [[protein]] family shares highly conserved [[DNA]] binding [[protein domain|domains]] known as HMG ([[High-mobility group]]) box domains containing approximately 80 [[amino acids]].<ref name=":0" />

Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine.<ref name="pmid20016762">{{cite journal | vauthors = Rizzino A | title = Sox2 and Oct-3/4: a versatile pair of master regulators that orchestrate the self-renewal and pluripotency of embryonic stem cells | journal = Wiley Interdisciplinary Reviews: Systems Biology and Medicine | volume = 1 | issue = 2 | pages = 228–36 | year = 2009 | pmid = 20016762 | pmc = 2794141 | doi = 10.1002/wsbm.12 }}</ref>

== Function ==

=== Stem cell pluripotency ===

LIF ([[Leukemia inhibitory factor]]) signaling, which maintains pluripotency in mouse embryonic stem cells, activates Sox2 downstream of the [[JAK-STAT signaling pathway]] and subsequent activation of [[KLF4|Klf4]] (a member of the family of [[Kruppel-like factors]]).  [[Oct-4]], Sox2 and [[Homeobox protein NANOG|Nanog]] positively regulate transcription of all pluripotency circuitry proteins in the LIF pathway.<ref name="pmid19571885">{{cite journal | vauthors = Niwa H, Ogawa K, Shimosato D, Adachi K | title = A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells | journal = Nature | volume = 460 | issue = 7251 | pages = 118–22 | date = July 2009 | pmid = 19571885 | doi = 10.1038/nature08113 }}</ref>

[[NPM1]], a transcriptional regulator involved in cell proliferation, individually forms [[Multiprotein complex|complexes]] with Sox2, [[OCT4|Oct4]] and [[Homeobox protein NANOG|Nanog]] in embryonic stem cells.<ref name="pmid21076177">{{cite journal | vauthors = Johansson H, Simonsson S | title = Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination | journal = Aging | volume = 2 | issue = 11 | pages = 815–22 | date = November 2010 | pmid = 21076177 | pmc = 3006024 | doi = 10.18632/aging.100222 }}</ref>  These three pluripotency factors contribute to a complex molecular network that regulates a number of genes controlling pluripotency. Sox2 binds to DNA cooperatively with Oct4 at non-palindromic sequences to activate transcription of key pluripotency factors.<ref name="Chambers_Tomlinson_2009">{{cite journal | vauthors = Chambers I, Tomlinson SR | title = The transcriptional foundation of pluripotency | journal = Development | volume = 136 | issue = 14 | pages = 2311–22 | date = July 2009 | pmid = 19542351 | pmc = 2729344 | doi = 10.1242/dev.024398 }}</ref> Surprisingly, regulation of Oct4-Sox2 enhancers can occur without Sox2, likely due to expression of other Sox proteins.  However, a group of researchers concluded that the primary role of Sox2 in embryonic stem cells is controlling Oct4 expression, and they both perpetuate their own expression when expressed concurrently.<ref name="pmid17515932">{{cite journal | vauthors = Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A, Matoba R, Sharov AA, Ko MS, Niwa H | title = Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells | journal = Nature Cell Biology | volume = 9 | issue = 6 | pages = 625–35 | date = June 2007 | pmid = 17515932 | doi = 10.1038/ncb1589 }}</ref>

In an experiment involving mouse embryonic stem cells, it was discovered that Sox2 in conjunction with Oct4, [[c-Myc]] and Klf4 were sufficient for producing [[induced pluripotent stem cell]]s.<ref name="Takahashi_Yamanaka_2006">{{cite journal | vauthors = Takahashi K, Yamanaka S | title = Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors | journal = Cell | volume = 126 | issue = 4 | pages = 663–76 | date = August 2006 | pmid = 16904174 | doi = 10.1016/j.cell.2006.07.024 }}</ref> The discovery that expression of only four transcription factors was necessary to induce pluripotency allowed future regenerative medicine research to be conducted considering minor manipulations.

Loss of pluripotency is regulated by hypermethylation of some Sox2 and Oct4 binding sites in male germ cells<ref name="Imamura_2006">{{cite journal | vauthors = Imamura M, Miura K, Iwabuchi K, Ichisaka T, Nakagawa M, Lee J, Kanatsu-Shinohara M, Shinohara T, Yamanaka S | title = Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells | journal = BMC Developmental Biology | volume = 6 | issue =  | pages = 34 | year = 2006 | pmid = 16859545 | pmc = 1564388 | doi = 10.1186/1471-213X-6-34 }}</ref> and post-transcriptional suppression of Sox2 by miR134.<ref name="Tay_2008">{{cite journal | vauthors = Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I | title = MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation | journal = Nature | volume = 455 | issue = 7216 | pages = 1124–8 | date = October 2008 | pmid = 18806776 | doi = 10.1038/nature07299 }}</ref>

Varying levels of Sox2 affect embryonic stem cells' fate of differentiation. Sox2 inhibits differentiation into the mesendoderm [[germ layer]] and promotes differentiation into neural [[ectoderm]] germ layer.<ref name="Thomson_2011">{{cite journal | vauthors = Thomson M, Liu SJ, Zou LN, Smith Z, Meissner A, Ramanathan S | title = Pluripotency factors in embryonic stem cells regulate differentiation into germ layers | journal = Cell | volume = 145 | issue = 6 | pages = 875–89 | date = June 2011 | pmid = 21663792 | doi = 10.1016/j.cell.2011.05.017 }}</ref>  [[NPM1|Npm1]]/Sox2 complexes are sustained when differentiation is induced along the ectodermal lineage, emphasizing an important functional role for Sox2 in ectodermal differentiation.<ref name="pmid21076177" />

A study conducted in Milano, Italy showed, through the development of a [[Knockout mouse|knockout]] model, that deficiency of Sox2 results in neural malformities and eventually fetal death, further underlining Sox2’s vital role in embryonic development.<ref name="Feri_et_al_2004">{{cite journal | vauthors = Ferri AL, Cavallaro M, Braida D, Di Cristofano A, Canta A, Vezzani A, Ottolenghi S, Pandolfi PP, Sala M, DeBiasi S, Nicolis SK | title = Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain | journal = Development | volume = 131 | issue = 15 | pages = 3805–19 | date = August 2004 | pmid = 15240551 | doi = 10.1242/dev.01204 }}</ref>

=== Neural stem cells ===

In [[neurogenesis]], Sox2 is expressed throughout developing cells in the [[neural tube]] as well as in proliferating [[central nervous system]] progenitors.  However, Sox2 is [[downregulated]] during progenitors' final cell cycle during differentiation when they become post [[mitotic]].<ref name="Graham">{{cite journal | vauthors = Graham V, Khudyakov J, Ellis P, Pevny L | title = SOX2 functions to maintain neural progenitor identity | journal = Neuron | volume = 39 | issue = 5 | pages = 749–65 | date = August 2003 | pmid = 12948443 | doi = 10.1016/S0896-6273(03)00497-5 }}</ref>  Cells expressing Sox2 are capable of both producing cells identical to themselves and differentiated neural cell types, two necessary hallmarks of stem cells.  Proliferation of Sox2+ [[neural stem cells]] can generate neural precursors as well as Sox2+ neural stem cell population.<ref name="Suh_2007">{{cite journal | vauthors = Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH | title = In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus | journal = Cell Stem Cell | volume = 1 | issue = 5 | pages = 515–28 | date = November 2007 | pmid = 18371391 | pmc = 2185820 | doi = 10.1016/j.stem.2007.09.002 }}</ref>

Induced pluripotency is possible using adult neural stem cells, which express higher levels of Sox2 and c-Myc than embryonic stem cells.  Therefore, only two exogenous factors, one of which is necessarily Oct4, are sufficient for inducing pluripotent cells from neural stem cells, lessening the complications and risks associated with introducing multiple factors to induce pluripotency.<ref name="pmid18594515">{{cite journal | vauthors = Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M, Schöler HR | title = Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors | journal = Nature | volume = 454 | issue = 7204 | pages = 646–50 | date = July 2008 | pmid = 18594515 | doi = 10.1038/nature07061 }}</ref>

=== Eye deformities ===

Mutations in this gene have been linked with bilateral [[anophthalmia]], a severe structural eye deformity.<ref name="entrez">{{cite web | title = Entrez Gene: SOX2 SRY (sex determining region Y)-box 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6657| accessdate = }}</ref>

=== Cancer ===

In lung development, Sox2 controls the branching morphogenesis of the bronchial tree and differentiation of the epithelium of airways.  Overexpression causes an increase in neuroendocrine, gastric/intestinal and basal cells.<ref name="Gontan_2008">{{cite journal | vauthors = Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R | title = Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation | journal = Developmental Biology | volume = 317 | issue = 1 | pages = 296–309 | date = May 2008 | pmid = 18374910 | doi = 10.1016/j.ydbio.2008.02.035 }}</ref>  Under normal conditions, Sox2 is critical for maintaining self-renewal and appropriate proportion of basal cells in adult tracheal epithelium.  However, its overexpression gives rise to extensive epithelial [[hyperplasia]] and eventually carcinoma in both developing and adult mouse lungs.<ref name="Lu_2010">{{cite journal | vauthors = Lu Y, Futtner C, Rock JR, Xu X, Whitworth W, Hogan BL, Onaitis MW | title = Evidence that SOX2 overexpression is oncogenic in the lung | journal = PLoS ONE | volume = 5 | issue = 6 | pages = e11022 | year = 2010 | pmid = 20548776 | pmc = 2883553 | doi = 10.1371/journal.pone.0011022 }}</ref>

In [[squamous cell carcinoma]], gene amplifications frequently target the 3q26.3 region.  The gene for Sox2 lies within this region, which effectively characterizes Sox2 as an [[oncogene]].  Sox2 is a key upregulated factor in lung squamous cell carcinoma, directing many genes involved in tumor progression.  Sox2 overexpression cooperates with loss of Lkb1 expression to promote squamous cell lung cancer in mice.<ref>{{cite journal | vauthors = Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG | title = Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer | journal = Cell Reports | volume = 8 | issue = 1 | pages = 40–9 | date = July 2014 | pmid = 24953650 | doi = 10.1016/j.celrep.2014.05.036 | pmc=4410849}}</ref> Its overexpression also activates cellular migration and anchorage-independent growth.<ref name="Hussenet_2010">{{cite journal | vauthors = Hussenet T, Dali S, Exinger J, Monga B, Jost B, Dembelé D, Martinet N, Thibault C, Huelsken J, Brambilla E, du Manoir S | title = SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas | journal = PLoS ONE | volume = 5 | issue = 1 | pages = e8960 | year = 2010 | pmid = 20126410 | pmc = 2813300 | doi = 10.1371/journal.pone.0008960 }}</ref>

Sox2 expression is also found in high [[gleason grade]] [[prostate cancer]], and promotes [[castration-resistant prostate cancer]] growth.<ref name="Kregel_2013">{{cite journal | vauthors = Kregel S, Kiriluk KJ, Rosen AM, Cai Y, Reyes EE, Otto KB, Tom W, Paner GP, Szmulewitz RZ, Vander Griend DJ | title = Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer | journal = PLoS ONE | volume = 8 | issue = 1 | pages = e53701 | year = 2013 | pmid = 23326489 | pmc = 3543364 | doi = 10.1371/journal.pone.0053701 }}</ref>

The ectopic expression of SOX2 may be related to abnormal differentiation of [[colorectal cancer]] cells.<ref name="pmid17136346">{{cite journal | vauthors = Tani Y, Akiyama Y, Fukamachi H, Yanagihara K, Yuasa Y | title = Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression | journal = Journal of Cancer Research and Clinical Oncology | volume = 133 | issue = 4 | pages = 263–9 | date = April 2007 | pmid = 17136346 | doi = 10.1007/s00432-006-0165-x }}</ref>

Sox2 has been shown to be relevant in the development of Tamoxifen resistance in breast cancer.<ref>{{cite journal | vauthors = Piva M, Domenici G, Iriondo O, Rábano M, Simões BM, Comaills V, Barredo I, López-Ruiz JA, Zabalza I, Kypta R, ((Vivanco Md)) | title = Sox2 promotes tamoxifen resistance in breast cancer cells | journal = EMBO Molecular Medicine | volume = 6 | issue = 1 | pages = 66–79 | date = January 2014 | pmid = 24178749 | doi = 10.1002/emmm.201303411 | pmc=3936493}}</ref>

== Regulation by thyroid hormone ==

There are three [[thyroid hormone]] response elements (TREs) in the region upstream of the Sox2 promoter. This region is known as the enhancer region. Studies have suggested that thyroid hormone (T3) controls Sox2 expression via the enhancer region. The expression of TRα1 (thyroid hormone receptor) is increased in proliferating and migrating neural stem cells. It has therefore been suggested that transcriptional repression of Sox2, mediated by the thyroid hormone signaling axis, allows for neural stem cell commitment and migration from the sub-ventricular zone. A deficiency of thyroid hormone, particularly during the first trimester, will lead to abnormal central nervous system development.<ref name="pmid22560077">{{cite journal | vauthors = López-Juárez A, Remaud S, Hassani Z, Jolivet P, Pierre Simons J, Sontag T, Yoshikawa K, Price J, Morvan-Dubois G, Demeneix BA | title = Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche | journal = Cell Stem Cell | volume = 10 | issue = 5 | pages = 531–43 | date = May 2012 | pmid = 22560077 | doi = 10.1016/j.stem.2012.04.008 }}</ref>
Further supporting this conclusion is the fact that hypothyroidism during fetal development can result in a variety of neurological deficiencies, including cretinism, characterized by stunted physical development and mental retardation.<ref name="pmid22560077" />

Hypothyroidism can arise from a multitude of causes, and is commonly remedied with hormone treatments such as the commonly used Levothyroxine.<ref name = "Wisse_2013">{{ cite encyclopedia | author = Wisse B | title = Hypothyroidism: MedlinePlus Medical Encyclopedia. | publisher = U.S National Library of Medicine | accessdate = April 10, 2014 | url =  https://www.nlm.nih.gov/medlineplus/ency/article/000353.htm }}</ref>

== Interactions ==

SOX2 has been shown to [[Protein-protein interaction|interact]] with [[PAX6]],<ref name="pmid12710953">{{cite journal | vauthors = Aota S, Nakajima N, Sakamoto R, Watanabe S, Ibaraki N, Okazaki K | title = Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene | journal = Developmental Biology | volume = 257 | issue = 1 | pages = 1–13 | date = May 2003 | pmid = 12710953 | doi = 10.1016/S0012-1606(03)00058-7 }}</ref> NPM1,<ref name="pmid19571885" /> and [[Oct4]].<ref name="Chambers_Tomlinson_2009" /> SOX2 has been found to cooperatively regulate [[Rex1]] with [[Oct3/4]].<ref name="pmid16714766">{{cite journal | vauthors = Shi W, Wang H, Pan G, Geng Y, Guo Y, Pei D | title = Regulation of the pluripotency marker Rex-1 by Nanog and Sox2 | journal = Journal of Biological Chemistry | volume = 281 | issue = 33 | pages = 23319–25 | date = August 2006 | pmid = 16714766 | doi = 10.1074/jbc.M601811200 }}</ref>

== References ==
{{reflist|35em}}

== Further reading ==
{{refbegin|35em}}

* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends in Genetics | volume = 16 | issue = 4 | pages = 182–7 | date = April 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = August 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
* {{cite journal | vauthors = Hever AM, Williamson KA, van Heyningen V | title = Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2 | journal = Clinical Genetics | volume = 69 | issue = 6 | pages = 459–70 | date = June 2006 | pmid = 16712695 | doi = 10.1111/j.1399-0004.2006.00619.x }}
* {{cite journal | vauthors = Yuan H, Corbi N, Basilico C, Dailey L | title = Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3 | journal = Genes & Development | volume = 9 | issue = 21 | pages = 2635–45 | date = November 1995 | pmid = 7590241 | doi = 10.1101/gad.9.21.2635 }}
* {{cite journal | vauthors = Stevanovic M, Zuffardi O, Collignon J, Lovell-Badge R, Goodfellow P | title = The cDNA sequence and chromosomal location of the human SOX2 gene | journal = Mammalian Genome | volume = 5 | issue = 10 | pages = 640–2 | date = October 1994 | pmid = 7849401 | doi = 10.1007/BF00411460 }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Helland R, Berglund GI, Otlewski J, Apostoluk W, Andersen OA, Willassen NP, Smalås AO | title = High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes | journal = Acta Crystallographica Section D | volume = 55 | issue = Pt 1 | pages = 139–48 | date = January 1999 | pmid = 10089404 | doi = 10.1107/S090744499801052X }}
* {{cite journal | vauthors = Güre AO, Stockert E, Scanlan MJ, Keresztes RS, Jäger D, Altorki NK, Old LJ, Chen YT | title = Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4198–203 | date = April 2000 | pmid = 10760287 | pmc = 18195 | doi = 10.1073/pnas.97.8.4198 }}
* {{cite journal | vauthors = Ambrosetti DC, Schöler HR, Dailey L, Basilico C | title = Modulation of the activity of multiple transcriptional activation domains by the DNA binding domains mediates the synergistic action of Sox2 and Oct-3 on the fibroblast growth factor-4 enhancer | journal = The Journal of Biological Chemistry | volume = 275 | issue = 30 | pages = 23387–97 | date = July 2000 | pmid = 10801796 | doi = 10.1074/jbc.M000932200 }}
* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Tanouchi A, Sekido R, Kondoh H | title = Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development | journal = Genes & Development | volume = 15 | issue = 10 | pages = 1272–86 | date = May 2001 | pmid = 11358870 | pmc = 313803 | doi = 10.1101/gad.887101 }}
* {{cite journal | vauthors = Fantes J, Ragge NK, Lynch SA, McGill NI, Collin JR, Howard-Peebles PN, Hayward C, Vivian AJ, Williamson K, van Heyningen V, FitzPatrick DR | title = Mutations in SOX2 cause anophthalmia | journal = Nature Genetics | volume = 33 | issue = 4 | pages = 461–3 | date = April 2003 | pmid = 12612584 | doi = 10.1038/ng1120 }}
* {{cite journal | vauthors = Wiebe MS, Nowling TK, Rizzino A | title = Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity | journal = Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 17901–11 | date = May 2003 | pmid = 12637543 | doi = 10.1074/jbc.M212211200 }}
* {{cite journal | vauthors = Aota S, Nakajima N, Sakamoto R, Watanabe S, Ibaraki N, Okazaki K | title = Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene | journal = Developmental Biology | volume = 257 | issue = 1 | pages = 1–13 | date = May 2003 | pmid = 12710953 | doi = 10.1016/S0012-1606(03)00058-7 }}
* {{cite journal | vauthors = Schepers G, Wilson M, Wilhelm D, Koopman P | title = SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro | journal = Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 28101–8 | date = July 2003 | pmid = 12732652 | doi = 10.1074/jbc.M304067200 }}
* {{cite journal | vauthors = Reményi A, Lins K, Nissen LJ, Reinbold R, Schöler HR, Wilmanns M | title = Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers | journal = Genes & Development | volume = 17 | issue = 16 | pages = 2048–59 | date = August 2003 | pmid = 12923055 | pmc = 196258 | doi = 10.1101/gad.269303 }}
* {{cite journal | vauthors = Williams DC, Cai M, Clore GM | title = Molecular basis for synergistic transcriptional activation by Oct1 and Sox2 revealed from the solution structure of the 42-kDa Oct1.Sox2.Hoxb1-DNA ternary transcription factor complex | journal = Journal of Biological Chemistry | volume = 279 | issue = 2 | pages = 1449–57 | date = January 2004 | pmid = 14559893 | doi = 10.1074/jbc.M309790200 }}
* {{cite journal | vauthors = Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M | title = Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia | journal = Journal of Cancer Research and Clinical Oncology | volume = 130 | issue = 3 | pages = 135–45 | date = March 2004 | pmid = 14655050 | doi = 10.1007/s00432-003-0519-6 }}
{{refend}}

== External links ==
* [https://web.archive.org/web/20090628185523/http://jura.wi.mit.edu/young_public/hESregulation/index.html Young Lab- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells]
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sox2  GeneReviews/NCBI/NIH/UW entry on SOX2-related eye disorders]
* [http://www.jove.com/index/details.stp?ID=734 Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4 (''Journal of Visualized Experiments'')]
* [https://www.ncbi.nlm.nih.gov/books/NBK1378/  GeneReviews/NCBI/NIH/UW entry on Anophthalmia / Microphthalmia Overview]
 
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[[Category:Transcription factors]]