View source for Singh-Williams-McAlister syndrome

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{{SK}} Talo-patello-scaphoid osteolysis

== Overview ==
Singh-Williams-McAlister syndrome<ref name="urlOrphanet: Talo patello scaphoid osteolysis">{{cite web |url=http://www.orpha.net//consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=50809 |title=Orphanet: Talo patello scaphoid osteolysis |format= |work= |accessdate=2012-08-17}}</ref> is a rare syndrome characterized by the resorption of bones (ankles, knees and wrists). Singh-Williams-McAlister syndrome is a syndrome belonging to the category of carpal-tarsal osteolysis diseases without nephropathy.

==Pathophysiology==
It is characterised by bilateral osteolysis of the tali, scaphoids, patella and short fourth metacarpals.
=== Genetics ===
Autosomal recessive inheritance is suspected.

== Epidemiology and Demographics ==
Prevalance: <1 / 1 000 000

== Diagnosis == 

=== Symptoms ===
The osteolysis is accompanied by periarticular swelling and pain.

== Treatment ==
Supportive care of chronic pain is required.

==References==
{{reflist|2}}

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[[Category:Disease]]
[[Category:Rare diseases]]
[[Category:Grammar]]