View source for Small nucleolar RNA Me28S-Am2634

{{Rfam_box|acc=RF00537|description=Small nucleolar RNA Me28S-Am2634|abbreviation=snoMe28S-Am2634|type=Gene; snRNA; guide; CD-box;|avg_length=90.2|avg_identity=83|ss=Predicted; ILM; Daub J|se={{PMID|15987805}}|type=Gene; snRNA; guide; CD-box;}}

'''Small nucleolar RNA Me28S-Am2634''' (also known as '''snoRNA Me28S-Am2634''')  is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis of other [[small nuclear RNA]]s (snRNAs). [[snoRNA|Small nucleolar RNA]]s (snoRNAs) are modifiying RNAs and usually located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. 

snoRNA  Me28S-Am2634 belongs to the [[SnoRNA#C.2FD box|C/D box]] class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs<ref>{{cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663&ndash;6668 | id = PMID 12215523}}</ref>.  It is predicted to guide the 2'-O-methylation of 28S ribosomal RNA (rRNA) residue A-2634 <ref name="pmid15987805">{{cite journal |author=Huang ZP, Zhou H, He HL, Chen CL, Liang D, Qu LH |title=Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs |journal=RNA |volume=11 |issue=8 |pages=1303-16 |year=2005 |pmid=15987805 |doi=10.1261/rna.2380905 |issn=}}</ref>.

This snoRNA has currently only been identified in [[Drosophila melanogaster]]. 

==References==

{{reflist|2}}

==External links==
* {{Rfam|id=RF00537|name=Small nucleolar RNA Me28S-Am2634}}

[[Category:Small nuclear RNA]]

{{molecular-cell-biology-stub}}
{{WikiDoc Sources}}