View source for Small nucleolar RNA Z102/R77

{{Rfam_box|acc=RF00359|description=Small nucleolar RNA Z102/R77|abbreviation=snoZ102_R77|type=Gene; snRNA; guide; CD-box;|avg_length=86.5|avg_identity=89|ss=Predicted; PFOLD; Moxon SJ|se=Moxon SJ|type=Gene; snRNA; guide; CD-box;}}

'''Small nucleolar RNA RZ102/R77''' refers to a group of related [[non-coding RNA]] (ncRNA) molecules which function in the biogenesis of other [[small nuclear RNA]]s (snRNAs). These [[snoRNA|small nucleolar RNA]]s (snoRNAs) are modifiying RNAs and usually located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. 

These two snoRNAs R77 and Z102 were identified in the plant ''[[Arabidopsis thaliana]]'' <ref name="pmid11469857">{{cite journal |author=Barneche F, Gaspin C, Guyot R, Echeverría M |title=Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites |journal=J. Mol. Biol. |volume=311 |issue=1 |pages=57-73 |year=2001 |pmid=11469857 |doi=10.1006/jmbi.2001.4851 |issn=}}</ref> and rice ''[[Oryza sativa]]'' <ref name="pmid12736310">{{cite journal |author=Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH |title=The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa |journal=Nucleic Acids Res. |volume=31 |issue=10 |pages=2601-13 |year=2003 |pmid=12736310 |doi= |issn=}}</ref> respectively. These related snoRNAs are predicted to belong to the [[SnoRNA#C.2FD box|C/D box]] class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs<ref>{{cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663&ndash;6668 | id = PMID 12215523}}</ref>.

Z102 and R77 and are members of the C/D class of snoRNA which contain the C (UGAUGA) and  D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1,2,3]. 

==References==
{{reflist|2}}

==External links==
* {{Rfam|id=RF00359|name=Small nucleolar RNA Z102/R77}}
* [http://bioinf.scri.sari.ac.uk/cgi-bin/plant_snorna/home plant snoRNA database]

[[Category:Small nuclear RNA]]

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