View source for TAAR2

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{{Infobox_gene}}
'''Trace amine-associated receptor 2''' ('''TAAR2'''), formerly known as '''G protein-coupled receptor 58''' ('''GPR58'''), is a [[protein]] that in humans is encoded by the ''TAAR2'' [[gene]].<ref name="pmid10684976">{{cite journal | vauthors = Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A | title = Cloning and characterization of additional members of the G protein-coupled receptor family | journal = Biochim Biophys Acta | volume = 1490 | issue = 3 | pages = 311–23 |date=Jun 2000 | pmid = 10684976 | pmc =  | doi =  10.1016/s0167-4781(99)00241-9}}</ref><ref name="pmid15718104">{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 |date=Feb 2005 | pmid = 15718104 | pmc =  | doi = 10.1016/j.ygeno.2004.11.010 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAAR2 trace amine associated receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9287| accessdate = }}</ref><ref name="IUPHAR TAAR2">{{cite web|vauthors =Davenport AP, Alexander S, Sharman JL, Pawson AJ, Benson HE, Monaghan AE, Liew WC, Mpamhanga C, Battey J, Benya RV, Jensen RT, Karnik S, Kostenis E, Spindel E, Storjohann L, Tirupula K, Bonner TI, Neubig R, Pin JP, Spedding M, Harmar A|title = TAAR2|url=http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=167|website=IUPHAR/BPS Guide to PHARMACOLOGY|publisher=International Union of Basic and Clinical Pharmacology|accessdate=22 February 2017|date=25 June 2015}}</ref> TAAR2 is coexpressed with [[G alpha subunit|G<sub>α</sub> proteins]];<ref name="IUPHAR TAAR2" /> however, {{as of|February 2017|lc=y|post=,}} its [[signal transduction]] mechanisms have not been determined.<ref name="IUPHAR TAAR2" />

Human TAAR2 (hTAAR2) is expressed in the [[cerebellum]], [[olfactory sensory neurons]] in the [[olfactory epithelium]], and [[leukocyte]]s (i.e., white blood cells), among other tissues.<ref name="Human trace amines and hTAARs October 2016 review">{{cite journal | vauthors = Khan MZ, Nawaz W | title = The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system | journal = Biomed. Pharmacother. | volume = 83 | issue = | pages = 439–449 | date = October 2016 | pmid = 27424325 | doi = 10.1016/j.biopha.2016.07.002 }}</ref><ref name="TAAR2 3-iodothyronamine">{{cite journal | vauthors = Cichero E, Tonelli M | title = New insights into the structure of the trace amine-associated receptor 2: Homology modelling studies exploring the binding mode of 3-iodothyronamine | journal = Chem Biol Drug Des | volume = | issue = | pages = | date = November 2016 | pmid = 27863038 | doi = 10.1111/cbdd.12903 }}</ref> [[hTAAR1]] and hTAAR2 are both required for white blood cell activation by [[trace amines]] in [[granulocytes]].<ref name="pmid23315425">{{cite journal |vauthors = Babusyte A, Kotthoff M, Fiedler J, Krautwurst D |title = Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2 |journal = J. Leukoc. Biol. |volume = 93 |issue = 3 |pages = 387–94 |date = March 2013  |pmid = 23315425 |doi = 10.1189/jlb.0912433 }}</ref> <!--[[Phenethylamine]], [[para-tyramine]], and [[3-iodothyronamine]] are [[full agonist]]s of hTAAR2 with [[EC50|EC<sub>50</sub>]] values of 0.43&nbsp;±&nbsp;0.05&nbsp;{{abbrlink|nM|nanomolar}}, 0.52&nbsp;±&nbsp;0.05&nbsp;nM, and 0.25&nbsp;±&nbsp;0.04&nbsp;nM respectively.<ref name="Human trace amines and hTAARs October 2016 review" />-->

A [[single nucleotide polymorphism]] [[nonsense mutation]] of the TAAR2 gene is associated with [[schizophrenia]].<ref name="IUPHAR TAAR2" /><ref name="Human trace amines and hTAARs October 2016 review" /> TAAR2 is a probable [[pseudogene]] in 10–15% of Asians as a result of a [[Genetic polymorphism|polymorphism]] that produces a [[premature stop codon]] at amino acid 168.<ref name="IUPHAR TAAR2" />

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==See also==
* [[Trace amine]]
* [[Trace amine-associated receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
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*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
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{{NLM content}}

{{TAAR ligands|state=expanded}}
{{G protein-coupled receptors}}
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[[Category:G protein-coupled receptors]]


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