View source for Tachykinin receptor

{{protein
| Name = [[tachykinin receptor 1]]
| caption = 
| image = 
| width = 
| HGNCid = 11526
| Symbol = TACR1
| AltSymbols = TAC1R
| EntrezGene = 6869
| OMIM = 162323
| RefSeq = NM_001058
| UniProt = P25103
| PDB = 
| ECnumber = 
| Chromosome = 2
| Arm = p
| Band = 13.1
| LocusSupplementaryData = -p12
}}
{{protein
| Name = [[tachykinin receptor 2]]
| caption = 
| image = 
| width = 
| HGNCid = 11527
| Symbol = TACR2
| AltSymbols = TAC2R, NKNAR
| EntrezGene = 6865
| OMIM = 162321
| RefSeq = NM_001057
| UniProt = P21452
| PDB = 
| ECnumber = 
| Chromosome = 10
| Arm = q11
| Band = -q21
| LocusSupplementaryData = 
}}
{{protein
| Name = [[tachykinin receptor 3]]
| caption = 
| image = 
| width = 
| HGNCid = 11528
| Symbol = TACR3
| AltSymbols = 
| EntrezGene = 6870
| OMIM = 162332
| RefSeq = NM_001059
| UniProt = P29371
| PDB = 
| ECnumber = 
| Chromosome = 4
| Arm = q
| Band = 25
| LocusSupplementaryData = 
}}

There are three known [[mammalian]] '''[[tachykinin]] receptors''' termed NK<sub>1</sub>, NK<sub>2</sub> and NK<sub>3</sub>. All are members of the [[7 transmembrane]] [[G-protein coupled receptor]] family and induce the activation of [[phospholipase C]], producing [[inositol triphosphate]] (so called G<sub>q</sub>-coupled).

==Binding==
The genes and receptor ligands are as follows:<ref name="pmid7557266">{{cite journal | vauthors = Maggi CA | title = The mammalian tachykinin receptors | journal = General Pharmacology | volume = 26 | issue = 5 | pages = 911–44 | date = September 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}</ref>

{| class="wikitable"
| '''Receptor ''' || '''Gene''' || '''Preferred ligand'''
 |- 
 | [[Tachykinin receptor 1|NK<sub>1</sub>]] || {{Gene|TACR1}} || [[substance P]]
 |- 
 | [[Tachykinin receptor 2|NK<sub>2</sub>]] || {{Gene|TACR2}} || [[neurokinin A]]
 |- 
 | [[Tachykinin receptor 3|NK<sub>3</sub>]] || {{Gene|TACR3}} || [[neurokinin B]]
|}

([[Tomas Hökfelt|Hökfelt]] et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

== See also ==
*[[Substance P]]
*[[G protein coupled receptor]]s

== References ==
{{reflist}}

== External links ==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1354 | title = Tachykinin Receptors | access-date = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
* {{MeshName|Tachykinin+Receptor}}

{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
{{Neurokinin receptor modulators}}

[[Category:G protein-coupled receptors]]
[[Category:Molecular neuroscience]]

{{biochem-stub}}