View source for Template:Nitric oxide signaling modulators

{{Navbox
| name  = Nitric oxide signaling modulators
| title = [[Nitric oxide]] [[cell signaling|signaling]] [[receptor modulator|modulator]]s
| state = {{{state<includeonly>|collapsed</includeonly>}}}
| listclass = hlist
| groupstyle = text-align:center;

 | group1 = [[Nitric oxide|Forms]]
 | list1 = 
* [[Nitroxyl|Nitroxyl anion (NO<sup>−</sup>; oxonitrate(1-), hyponitrite anion)]]
* [[Nitric oxide|Nitric oxide (NO<sup>⋅</sup>; nitrogen monoxide)]]
* [[Nitrosonium|Nitrosonium (NO<sup>+</sup>; nitrosyl cation)]]

 | group2 = [[Biological target|Target]]s
 | list2 = {{Navbox|child
 | groupstyle = text-align:center;

  | group1 = [[Soluble guanylate cyclase|sGC]]<!--Major pathway of NO action; NO directly binds to and activates-->
  | list1 = 
* ''Activators/stimulators:'' [[Ataciguat]]
* [[BAY 41-2272]]
* [[BAY 41-8543]]
* [[BAY 60-4552]]
* [[BI-703704]]
* [[Cinaciguat|Cinaciguat (BAY 58-2667)]]
* [[GSK-2181236A]]
* [[Praliciguat]]
* [[Riociguat|Riociguat (BAY 63-2521)]]
* [[Vericiguat]]

* ''Inhibitors:'' [[1H-(1,2,4)Oxadiazolo(4,3-a)quinoxalin-1-one|ODQ]]

  }}

 | group3 = [[NO donor]]s<br /><small>([[prodrug]]s)</small>
 | list3 = 
<!--Note: Direct NO donors (spontaneously release NO): nitroso/nitrosyl; indirect NO donors (require metabolism to release NO): nitrates, NONOates, heterocyclics-->
* ''[[Nitrate]]s:'' [[Diethylene glycol dinitrate|Diethylene glycol dinitrate (DEGDN)]]
* [[Erythritol tetranitrate|Erythritol tetranitrate (ETN)]]
* [[Ethylene glycol dinitrate|Ethylene glycol dinitrate (EGDN; nitroglycol)]]
* [[Isosorbide mononitrate|Isosorbide mononitrate (ISMN)]]
* [[Isosorbide dinitrate|Isosorbide dinitrate (ISDN)]]
* [[Itramin tosilate]]
* [[Mannitol hexanitrate]]
* [[Naproxcinod|Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)]]<!--an NO-NSAID; naproxen derivative-->
* [[NCX-466]]<!--an NO-NSAID-->
* [[NCX-2216]]<!--an NO-NSAID; fluribuprofen derivative-->
* [[NCX-4016]]<!--an NO-NSAID; a nitroaspirin-->
* [[NCX 4040]]<!--an NO-NSAID; a nitroaspirin-->
* [[NCX-4215]]<!--an NO-NSAID; a nitroaspirin-->
* [[Nicorandil]]<!--nicotinamide derivative with a nitrate group and NO donor properties-->
* [[Nipradilol|Nipradilol (K-351)]]<!--beta blocker with a nitrate group and NO donor properties-->
* [[Nitrate|Nitrate (NO{{su|b=3|p=−}})]]
* [[Nitroatorvastatin|Nitroatorvastatin (NCX-6560)]]
* [[Nitroflurbiprofen|Nitroflurbiprofen (HCT-1026)]]<!--an NO-NSAID; fluribuprofen derivative-->
* [[Nitrofluvastatin|Nitrofluvastatin]]
* [[Nitroglycerin (drug)|Nitroglycerin (glyceryl trinitrate (GTN))]]
* [[Nitropravastatin|Nitropravastatin (NCX-6550)]]<!--pravastatin derivative with a nitrate group and NO donor properties-->
* [[Pentaerithrityl tetranitrate|Pentaerithrityl tetranitrate (PETN)]]
* [[Propatylnitrate]]
* [[Propylene glycol dinitrate|Propylene glycol dinitrate (PGDN)]]
* [[Sodium trioxodinitrate|Sodium trioxodinitrate (Angeli's salt)]]
* [[Tenitramine]]
* [[Trolnitrate]]

* ''[[Nitroso compound]]s/[[nitrite]]s:'' [[Nitrite|Nitrite (NO{{su|b=2|p=−}})]]; ''O-Nitroso compounds ([[alkyl nitrite]]s):'' [[Amyl nitrite|Amyl nitrite (isoamyl nitrite, isopentyl nitrite)]]
* [[Cyclohexyl nitrite]]
* [[Ethyl nitrite]]
* [[Hexyl nitrite]]
* [[Isobutyl nitrite|Isobutyl nitrite (2-methylpropyl nitrite)]]
* [[Isopropyl nitrite]]
* [[Methyl nitrite]]
* [[Butyl nitrite|''n''-Butyl nitrite]]
* [[Pentyl nitrite]]
* [[tert-Butyl nitrite|''tert''-Butyl nitrite]]; ''[[S-Nitrosothiol|S-Nitroso compound]]s (thionitrites):'' [[LA810]]<!--analogue of GSNO-->
* [[S-Nitrosoalbumin|S-Nitrosoalbumin (SNALB)]]
* [[S-Nitrosated AR545C]]
* [[S-Nitroso-N-acetylcysteine|S-Nitroso-N-acetylcysteine (SNAC)]]
* [[S-Nitroso-N-acetylpenicillamine|S-Nitroso-N-acetylpenicillamine (SNAP)]]
* [[S-Nitroso-N-valerylpenicillamine|S-Nitroso-N-valerylpenicillamine (SNVP)]]
* [[S-Nitrosocaptopril|S-Nitrosocaptopril (SNO-Cap)]]<!--captopril derivative with NO donor properties-->
* [[S-Nitrosocysteine|S-Nitrosocysteine (SNC, CysNO, SNO-Cys)]]
* [[S-Nitrosodiclofenac]]
* [[S-Nitrosoglutathione|S-Nitrosoglutathione (GSNO, SNOG)]]
* [[S-Nitrosated tissue-type plasminogen activator|SNO-t-PA]]
* [[S-Nitrosated von Willebrand factor|SNO-vWF]]; ''N-Nitroso compounds (e.g., [[nitrosamine]]s):'' [[SIN-1A]]<!--N-nitroso-N-morpholinoamino-acetonitrile-->

* ''Nitrosyl compounds:'' ''[[Metal nitrosyl complex]]es:'' [[Roussin's black salt]]
* [[Roussin's red salt]]
* [[Sodium nitroprusside|Sodium nitroprusside (SNP)]]

* ''[[NONOate]]s (diazeniumdiolates):'' [[Diethylamine/NO|Diethylamine/NO (DEA/NO)]]
* [[Diethylenetriamine/NO|Diethylenetriamine/NO (DETA/NO)]]
* [[GLO/NO]]<!--fluorescent compound-->
* [[JS-K]]
* [[Methylamine hexamethylene methylamine/NO|Methylamine hexamethylene methylamine/NO (MAHMA/NO)]]
* [[PROLI/NO]]<!--mixture of nitrosoproline and sodium methoxide-->
* [[Spermine/NO|Spermine/NO (SPER/NO)]]
* [[V-PYRRO/NO]]

* ''Heterocyclic compounds:'' ''[[Furoxan]]s:'' [[Furoxan]]
* [[REC15/2739]]; ''[[Sydnonimine]]s:'' [[Feprosidnine]]
* [[Linsidomine|Linsidomine (SIN-1)]]
* [[Molsidomine|Molsidomine (SIN-10)]]
* [[Sydnonimine]]

* ''Unsorted:'' [[CXL-1427]]
* [[FK-409]]
* [[FR144220]]
* [[FR146881]]
* [[N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide]]

 | group4 = [[Enzyme]]<br /><small>([[Enzyme inhibitor|inhibitor]]s)</small>
 | list4 = {{Navbox|child
 | groupstyle = text-align:center;

  | group1 = [[Nitric oxide synthase|NOS]]<!--L-arginine/NO-synthase pathway of NO production-->
  | list1 = {{Navbox|child
  | groupstyle = text-align:center;

    | group1 = [[NOS1|nNOS]]
    | list1 = 
* [[3-Bromo-7-nitroindazole]]
* [[3-Chloroindazole]]
* [[3-Chloro-5-nitroindazole]]
* [[5-Nitroindazole]]
* [[6-Nitroindazole]]
* [[7-Nitroindazole]]
* [[A-84643]]
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]<!--some selectivity for iNOS; highly non-selective; also a diamine oxidase, polyamine oxidase, general oxidase, ribonucleotide reductase, decarboxylase, catalase, and advanced glycosylation end product inhibitor-->
* [[ARL-17477]]
* [[Indazole]]
* [[N5-(1-Iminoethyl)-L-ornithine|N<sup>5</sup>-(1-Iminoethyl)-L-ornithine (<small>L</small>-NIO)]]
* [[Nω-Methyl-L-arginine|N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)]]
* [[Nω-Propyl-L-arginine|N<sup>ω</sup>-Propyl-<small>L</small>-arginine (<small>L</small>-NPA)]]<!--selective, unlike N-methyl variant-->
* [[Nitroarginine|Nitroarginine (NNA, NOARG)]]
* [[Pentamidine isethionate]]
* [[1-(2-Trifluoromethylphenyl)imidazole|TRIM]]

    | group2 = [[Nitric oxide synthase 2 (inducible)|iNOS]]
    | list2 = 
* [[1-Amino-2-hydroxyguanidine]]
* [[2-Ethylaminoguanidine]]
* [[2-Iminopiperidine]]
* [[1400W]]
* [[S-aminoethylisothiourea|AEITU]]
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]<!--some selectivity for iNOS; highly non-selective; also a diamine oxidase, polyamine oxidase, general oxidase, ribonucleotide reductase, decarboxylase, catalase, and advanced glycosylation end product inhibitor-->
* [[2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine|AMT]]
* [[AR-C 102222]]
* [[BYK-191023]]
* [[Canavanine]]
* [[Cindunistat|Cindunistat (SD-6010)]]
* [[S-Ethylisothiourea|EITU]]
* [[S-Isopropylisothiourea|IPTU]]
* [[S-Methylisothiourea|MITU]]
* [[N5-(1-Iminoethyl)-L-ornithine|N<sup>5</sup>-(1-Iminoethyl)-<small>L</small>-ornithine (<small>L</small>-NIO)]]
* [[N6-(1-Iminoethyl)-L-lysine|N<sup>6</sup>-(1-Iminoethyl)-<small>L</small>-lysine (<small>L</small>-NIL)]]
* [[Nω-Methyl-L-arginine|N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)]]
* [[Ronopterin|Ronopterin (VAS-203)]]
* [[1-(2-Trifluoromethylphenyl)imidazole|TRIM]]

    | group3 = [[Endothelial NOS|eNOS]]
    | list3 =
* [[Aminoguanidine|Aminoguanidine (pimagedine)]]<!--some selectivity for iNOS; highly non-selective; also a diamine oxidase, polyamine oxidase, general oxidase, ribonucleotide reductase, decarboxylase, catalase, and advanced glycosylation end product inhibitor-->
* [[N5-(1-Iminoethyl)-L-ornithine|N<sup>5</sup>-(1-Iminoethyl)-<small>L</small>-ornithine (<small>L</small>-NIO)]]
* [[Nω-Methyl-L-arginine|N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)]]
* [[Nitroarginine|Nitroarginine (NNA, NOARG)]]

    | group4 = Unsorted
    | list4 =
* [[Asymmetric dimethylarginine|Asymmetric dimethylarginine (ADMA)]]
* [[CKD-712]]
* [[Guanidinoethyldisulfide|Guanidinoethyldisulfide (GED)]]
* [[GW-273629]]
* [[Indospicine]]
* [[KD-7040]]
* [[Nitroarginine methyl ester|Nitroarginine methyl ester (NAME)]]
* [[NCX-456]]
* [[NXN-462]]
* [[ONO-1714]]
* [[VAS-2381]]

    }}

  | group2 = [[Nitrate reductase]]<!--nitrate-nitrite-NO pathway of NO production; enzyme is part of microbiome-->
  | list2 = 

  | group3 = [[Arginase]]<!--L-arginine → L-ornithine; limits L-arginine/NO pathway via reducing available L-arginine-->
  | list3 = 
* [[2S-Amino-6-boronohexonic acid|ABH]]
* [[Nω-Hydroxy-L-arginine|N<sup>ω</sup>-Hydroxy-<small>L</small>-arginine (NOHA)]]

  | group4 = [[CAMK]]<!--CaM inhibitors; limits cofactor for NO synthesis-->
  | list4 = 
* [[Calmidazolium]]
* [[W-7 (drug)|W-7]]

  | group5 = [[GTP cyclohydrolase I|GTPCH]]<!--BH<sub>4</sub> inhibitors; limits cofactor for NO synthesis-->
  | list5 = 

  | group6 = [[6-Pyruvoyltetrahydropterin synthase|PTPS]]<!--BH<sub>4</sub> inhibitors; limits cofactor for NO synthesis-->
  | list6 = 

  | group7 = [[Sepiapterin reductase|SPR]]<!--BH<sub>4</sub> inhibitors; limits cofactor for NO synthesis-->
  | list7 = 

  }}

| group5 = Others
| list5 =
* ''Precursors:'' [[Arginine|<small>L</small>-Arginine]]
* [[Nω-Hydroxy-L-arginine|N<sup>ω</sup>-Hydroxy-<small>L</small>-arginine (NOHA)]]

* ''Cofactors:'' [[Nicotinamide adenine dinucleotide phosphate|NADPH]]
* [[Flavin adenine dinucleotide|FAD]]
* [[Flavin mononucleotide|FMN]]
* [[Heme]]
* [[Tetrahydrobiopterin|BH<sub>4</sub>]]
* [[Calmodulin|CaM]]
* [[Oxygen|O<sub>2</sub>]]
* [[Calcium|Ca<sup>2+</sup>]]

* ''Indirect/downstream NO modulators:'' [[ACE inhibitor]]s/[[Angiotensin II receptor antagonist|AT-II receptor antagonist]]s (e.g., [[captopril]], [[losartan]])
* [[Endothelin receptor antagonist|ET<sub>B</sub> receptor antagonist]]s (e.g., [[bosentan]])
* [[L-Type calcium channel|L-Type calcium channel]] [[calcium channel blocker|blocker]]s (e.g., [[dihydropyridine]]s: [[nifedipine]])
* [[Nebivolol]] ([[beta blocker]])
* [[PDE5 inhibitor]]s (e.g., [[sildenafil]])
* [[Statin]]s (e.g., [[simvastatin]])

 | below = '''''See also:''' [[Template:Receptor modulators|Receptor/signaling modulators]]''

}}<noinclude>
{{collapsible option}}
[[Category:Drug templates by receptor, channel, or pump]]
</noinclude>