View source for Thin basement membrane disease natural history, complications and prognosis

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{{Thin basement membrane disease}}
{{CMG}}
{{AE}} {{MMT}}
==Overview==
[[Thin basement membrane disease|TBMD]] is may developed or found incidentally in first decade of life in symptomatic patient, may present symptoms later in third decade in asymptomatic patient. If left untreated, adult [[Thin basement membrane disease|TBMD]] patients with [[proteinuria]] may develop [[hypertension]], [[renal impairment]] leading to [[renal insufficiency]]. [[Prognosis]] is usually good in patient with isolated [[hematuria]] in [[Thin basement membrane disease|TBMD]].

==Natural history, complications and prognosis==
'''Natural History'''

*The symptoms of [[Thin basement membrane disease|TBMD]] are usually developed in first decade of life and start with symptoms such as [[Benign Recurrent Hamaturia|recurrent hematuria]]. It occurs rarely after age 50 years.
*The symptoms of [[Thin basement membrane disease|TBMD]] typically are not present initially, are found incidentally as [[microscopic hematuria]], [[Proteinuria|mild proteinuria]] in [[Urinalysis|routine urine analysis]] and [[Hematuria|macroscopic hematuria]] rarely.<ref name="pmid19670702">{{cite journal |vauthors=Zurawski J, Salwa-Zurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B |title=Clinical and morphological aspects of thin glomerular basement membrane disease |journal=Pol J Pathol |volume=60 |issue=1 |pages=35–42 |date=2009 |pmid=19670702 |doi= |url=}}</ref>
*If left untreated, adult [[Thin basement membrane disease|TBMD]] patients with [[proteinuria]] may develop [[hypertension]], [[renal impairment]] leading to [[renal insufficiency]]. <ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>

'''Complication'''

Common complications of [[Thin basement membrane disease|TBMD]] include<ref name="pmid15880328">{{cite journal |vauthors=Tonna S, Wang YY, MacGregor D, Sinclair R, Martinello P, Power D, Savige J |title=The risks of thin basement membrane nephropathy |journal=Semin Nephrol |volume=25 |issue=3 |pages=171–5 |date=May 2005 |pmid=15880328 |doi=10.1016/j.semnephrol.2005.01.009 |url=}}</ref>:

*[[Hypertension]].
*[[Proteinuria]].
*[[Renal impairment|Renal impairment.]]
*[[Renal failure|Renal failure.]]
*Anxiety.

'''Prognosis'''

*[[Prognosis]] is good in patient with isolated [[hematuria]].
*The presence of [[proteinuria]] or other [[glomerulopathy]] is associated with a particularly [[Prognosis|poor prognosis]] among patients with [[Thin basement membrane disease|TBMD]].<ref name="pmid31288791">{{cite journal |vauthors=Hashimoto H, Ohashi N, Tsuji N, Naito Y, Isobe S, Fujikura T, Tsuji T, Kato A, Nozu K, Iijima K, Yasuda H |title=A case report of thin basement membrane nephropathy accompanied by sporadic glomerulocystic kidney disease |journal=BMC Nephrol |volume=20 |issue=1 |pages=248 |date=July 2019 |pmid=31288791 |pmc=6617628 |doi=10.1186/s12882-019-1451-6 |url=}}</ref><ref name="pmid15880329">{{cite journal |vauthors=Norby SM, Cosio FG |title=Thin basement membrane nephropathy associated with other glomerular diseases |journal=Semin Nephrol |volume=25 |issue=3 |pages=176–9 |date=May 2005 |pmid=15880329 |doi=10.1016/j.semnephrol.2005.01.010 |url=}}</ref>

==References==

{{Reflist|2}}

[[Category:Kidney diseases]]
[[Category:Nephrology]]
[[Category:Disease]]
[[Category:Needs content]]

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