View source for Unstable angina / non ST elevation myocardial infarction (patient information)

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{{Unstable angina / non ST elevation myocardial infarction (patient information)}}

{{CMG}}; '''Associate Editor-In-Chief:''' [[Lakshmi Gopalakrishnan]], M.B.B.S.

==Overview==
[[Unstable angina]] is a condition in which your heart doesn't get enough blood flow and [[oxygen]]. It may be a prelude to a [[Heart attack (patient information)|heart attack]]. [[Angina]] is a type of chest discomfort caused by poor blood flow through the blood vessels (coronary vessels) of the heart muscle ([[myocardium]]).

==What are the symptoms of Unstable angina / Non ST-elevation myocardial infarction?== 
*Symptoms include:
:*Sudden [[chest pain]] that may also be felt in the shoulder, arm, jaw, neck, back, or other area
:*Pain that feels like tightness, squeezing, crushing, burning, choking, or aching
:*Pain that occurs at rest and does not easily go away when using medicine
:*[[Shortness of breath]]

*If you have [[Chronic stable angina (patient information)|stable angina]], you may be developing unstable angina if the [[chest pain]]:
:*Starts to feel different
:*Lasts longer than 15 - 20 minutes
:*Occurs at different times

==What causes Unstable angina / Non ST elevation myocardial infarction?==
*[[Coronary heart disease (patient information)|Coronary artery disease]] due to [[atherosclerosis]] is by far the most common cause of unstable angina. Atherosclerosis is the buildup of fatty material called plaque along the walls of the arteries. This causes arteries to become less flexible and narrow, which interrupts blood flow to the heart, causing [[chest pain]].

*At first, angina may be considered [[Chronic stable angina (patient information)|stable]]. The chest pain only occurs with activity or stress. The pain does not become more frequent or severe over time. 

*Unstable angina is chest pain that is sudden and gets increasingly worse. The chest pain:
:*Occurs without cause (for example, it wakes you up from sleep)
:*Lasts longer than 15 - 20 minutes
:*Responds poorly to a medicine called [[nitroglycerin]]
:*May occur along with a drop in [[blood pressure]] or significant [[shortness of breath]]
:*People with unstable angina are at increased risk of having a [[Heart attack (patient information)|heart attack]].

*[[Coronary vasospasm (patient information)|Coronary artery spasm]] is a rare cause of angina.

==Who is at highest risk?==
Risk factors for coronary artery disease include:
*[[Diabetes]]
*Family history of [[Coronary heart disease (patient information)|coronary heart disease]] before age 50
*[[High blood pressure]]
*High [[LDL]] cholesterol
*Low [[HDL]] cholesterol
*Male gender
*Not getting enough exercise
*[[Obesity]]
*Older age
*[[Smoking]]

==When to seek urgent medical care?== 
*Seek medical attention if you have new, unexplained [[chest pain]] or pressure. If you have had angina before, call your doctor.

*Call 911 if your angina pain:
:*Does not go away after 15 minutes
:*Does not go away after three doses of [[nitroglycerin]]
:*Is getting worse
:*Returns after the nitroglycerin helped at first

*Call your doctor if:
:*You are having angina symptoms more often.
:*You are having angina when you are sitting. This is called 'rest angina'.
:*You are feeling tired more often.
:*You are feeling faint or [[light-headed]], or you pass out.
:*Your heart is beating very slowly (less than 60 beats a minute) or very fast (more than 120 beats a minute), or it is not steady.
:*You are having trouble taking your heart medicines.
:*You have any other unusual symptoms.
:*If you think you are having a [[Heart attack (patient information)|heart attack]], seek immediate medical treatment.

==Diagnosis==
*The doctor will perform a physical examination and check your [[blood pressure]]. The doctor may hear abnormal sounds, such as a [[heart murmur]] or irregular heartbeat, when listening to your chest with a stethoscope.

*Tests to evaluate angina include:
:*Blood tests to show if you have heart tissue damage or are at a high risk for [[Heart attack (patient information)|heart attack]], including [[troponin I]] and T-00745, [[creatine phosphokinase]] (CPK), and [[myoglobin]]
:*[[ECG]]
:*[[Echocardiography]]
:*[[Stress test]]s
:*Chemical or pharmacologic stress test ([[adenosine]], [[dobutamine]])
:*Exercise tolerance test (stress test or treadmill test)
:*[[Exercise stress testing#Exercise/Pharmacologic Stress Echocardiography|Stress echocardiogram]]
:*Thallium stress test
:*Non-imaging (exercise treadmill) or imaging (nuclear stress test, echo stress test)
:*[[Coronary angiography]] (taking pictures of the heart arteries using x-rays and dye; it is the best test to diagnose significant heart disease)

==Treatment options== 
*Your doctor may want you to check into the hospital to get some rest and prevent complications.

*[[Blood thinners]] (antiplatelet drugs) are commonly used to treat and prevent unstable angina. Such medicines include [[aspirin]] and the prescription drug [[clopidogrel]]. Aspirin (and sometimes clopidogrel) may reduce the chance of a [[Heart attack (patient information)|heart attack]] in certain patients.

*During an unstable angina event, you may receive [[heparin]] (or another blood thinner) and [[nitroglycerin]] (under the tongue or through an IV). 

*Other treatments may include medicines to control [[blood pressure]], [[anxiety]], abnormal heart rhythms, and [[cholesterol]] (such as a [[statin]] drug).

*Often if a blood vessel is found to be narrowed or blocked, a procedure called [[Angioplasty (patient information)|angioplasty]] and stenting can be performed to open the artery. Angioplasty is a procedure to open narrowed or blocked blood vessels that supply blood to the heart. A coronary artery stent is a small, metal mesh tube that opens up (expands) inside a coronary artery. A stent is often placed after angioplasty. It helps prevent the artery from closing up again. A [[drug-eluting stent]] has medicine in it that helps prevent the artery from closing.

*[[Coronary artery bypass surgery (patient information)|Heart bypass surgery]] may be done for some people, depending on which and how many of their coronary arteries are narrowed and the severity of the narrowings.

===Medications to avoid===

{{MedCondContrPI

|MedCond =unstable angina|Fingolimod|Levothyroxine}}

==Where to find medical care for Unstable angina / Non ST elevation myocardial infarction?== 

[http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Unstable angina}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl Directions to Hospitals Treating Unstable angina / non ST elevation myocardial infarction]

==What to expect (Outlook/Prognosis)?==
How well you do depends on many different things, including:
*The severity of [[Coronary heart disease (patient information)|coronary artery disease]]
*The severity of the most current unstable angina attack
*Whether you've ever had a [[Heart attack (patient information)|heart attack]]
*The medicines you were taking when the angina attack started
*How well your heart muscle is pumping
*[[Arrhythmias]] and [[Heart attack (patient information)|heart attack]]s can cause [[Sudden cardiac death|sudden death]].

==Possible Complications== 
Unstable angina may lead to a [[Heart attack (patient information)|heart attack]].

==Prevention==
*Lifestyle changes can help prevent some angina attacks. Your doctor may tell you to:
:*Lose weight if you are [[overweight]]
:*Stop [[smoking]]
:*You should also keep strict control of your [[blood pressure]], [[diabetes]], and [[cholesterol]] levels. Some studies have shown that making a few lifestyle changes can prevent blockages from getting worse and may actually improve them.

*If you have one or more risk factors for [[Coronary heart disease (patient information)|heart disease]], talk to your doctor about possibly taking [[aspirin]] or other medicines to help prevent a [[Heart attack (patient information)|heart attack]]. 
:*[[Aspirin]] therapy (75 - 325 mg a day) or a drug called [[clopidogrel]] may help prevent heart attacks in some people. 
:*Aspirin therapy is recommended if the benefit is likely to outweigh the risk of gastrointestinal side effects.

==Source==
http://www.nlm.nih.gov/medlineplus/ency/article/000201.htm
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