View source for WBR0730

 {{WBRQuestion
|QuestionAuthor= {{YD}} (Reviewed by  {{YD}})
|ExamType=USMLE Step 1
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|MainCategory=Physiology
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|SubCategory=Endocrine
|MainCategory=Physiology
|MainCategory=Physiology
|SubCategory=Endocrine
|Prompt=A researcher is studying the role of lisinopril in the renin-angiotensin pathway. He conducts an experiment to compare the pathway with and without the administration of lisinopril. During his experiment, he notes the inhibition of the normal secretion of a compound from the adrenal gland with the administration of lisinopril.  Which area(s) in the adrenal gland is/are most likely involved in the researcher's experiment?
|Explanation=The use of lisinopril, an ACE-inhibitor, inhibits the renin-angiotensin system from producing aldosterone. Since ACE is inhibited, aldosterone will not be secreted from the adrenal gland. 

The adult adrenal gland contains an adrenal cortex and an adrenal medulla. The cortex contains 3 distinct layers that are arranged in order (from superficial to deep) in the following order: <br>
1- Glomerulosa<br>
2- Fasciculata<br>
3- Reticularis

Each layer in the adrenal cortex is involved in the secretion of specific compounds. The zona glomerulosa mainly secretes aldosterone, the zona fasciculata mainly secretes cortisol, and the zona reticularis mainly secretes sex hormones.  On the other hand, the medulla is the main secretory zone of catecholamines.
|AnswerA=Zone reticulata
|AnswerAExp=Sex hormones are mainly secreted from the zona reticulata in the cortex of the adrenal gland.
|AnswerB=Zona glomerulosa
|AnswerBExp=Aldosterone is mainly secreted from the zona glomerulosa in the cortex of the adrenal gland.
|AnswerC=Zona fasciculata
|AnswerCExp=Cortisol is mainly secreted from the zona fasciculata in the cortex of the adrenal gland.
|AnswerD=Medulla
|AnswerDExp=Catecholamines are mainly secreted from the medulla of the adrenal gland.
|AnswerE=Zona fasciculata and zona reticularis
|AnswerEExp=Neither the zona fasciculata nor the zona reticularis is involved in the main secretion of aldosterone from the adrenal gland.
|EducationalObjectives=Aldosterone is mainly secreted from the zona glomerulosa.
|References=First Aid 2014 page 306
|RightAnswer=B
|WBRKeyword=Zona, Glomerulosa, Fasciculata, Reticularis, Adrenal, Gland, Medulla, Aldosterone, Renin, Angiotensin, Ace inhibitor, Ace-inhibitor, Ace, Inhibitor, Lisinopril, Pathway, Secretion, Hormone
|Approved=Yes
}}