View source for YAF2

{{Infobox_gene}}
'''YY1-associated factor 2''' is a [[protein]] that in humans is encoded by the ''YAF2'' [[gene]].<ref name="pmid9016636">{{cite journal |vauthors=Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC | title = Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1 | journal = Nucleic Acids Res | volume = 25 | issue = 4 | pages = 843–9 |date=Mar 1997 | pmid = 9016636 | pmc = 146511 | doi =10.1093/nar/25.4.843  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: YAF2 YY1 associated factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10138| accessdate = }}</ref>

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| section_title = 
| summary_text = The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.<ref name="entrez" />
}}

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  |vauthors=Mädge B, Geisen C, Möröy T, Schwab M |title=Yaf2 inhibits Myc biological function |journal=Cancer Lett. |volume=193 |issue= 2 |pages= 171–6 |year= 2003 |pmid= 12706874 |doi=10.1016/S0304-3835(02)00696-1  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Ogawa H |title=A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells |journal=Science |volume=296 |issue= 5570 |pages= 1132–6 |year= 2002 |pmid= 12004135 |doi= 10.1126/science.1069861  |name-list-format=vanc| author2=Ishiguro K  | author3=Gaubatz S  | display-authors=3  | last4=Livingston  | first4=DM  | last5=Nakatani  | first5=Y }}
*{{cite journal  | author=Sawa C |title=YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22484–90 |year= 2002 |pmid= 11953439 |doi= 10.1074/jbc.M203060200  |name-list-format=vanc| author2=Yoshikawa T  | author3=Matsuda-Suzuki F  | display-authors=3  | last4=Deléhouzée  | first4=S  | last5=Goto  | first5=M  | last6=Watanabe  | first6=H  | last7=Sawada  | first7=J  | last8=Kataoka  | first8=K  | last9=Handa  | first9=H }}
*{{cite journal  |vauthors=Bannasch D, Mädge B, Schwab M |title=Functional interaction of Yaf2 with the central region of MycN |journal=Oncogene |volume=20 |issue= 41 |pages= 5913–9 |year= 2001 |pmid= 11593398 |doi= 10.1038/sj.onc.1204747 }}
}}
{{refend}}

==External links==
* {{UCSC genome browser|YAF2}}
* {{UCSC gene details|YAF2}}

{{PDB Gallery|geneid=10138}}

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