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| ==Overview==
| | #Redirect [[Yersinia pestis infection natural history, complications and prognosis]] |
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| ==Natural history==
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| ===Perspective and history===
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| Plague has a remarkable place in history. For centuries, plague represented disaster for those living in Asia, Africa and Europe, where, it has been said, populations were so affected that sometimes there were not enough people left alive to bury the dead (Gross, 1995). Because the cause of plague was unknown, plague outbreaks contributed to massive panic in cities and countries where it appeared. The [[disease]] was believed to be delivered upon the people by the displeasure of the gods, by other supernatural powers or, by heavenly disturbance. Innocent groups of people were blamed for spreading plague and were persecuted by the panicked masses. Numerous references in art, literature and monuments attest to the horrors and devastation of past plague [[epidemics]]. So imprinted in our minds is the fear of plague that, even now, entering into the 21st century, a suspected plague outbreak can incite mass panic and bring much of the world's economy to a temporary standstill. The number of human plague infections is low when compared to diseases caused by other agents, yet plague invokes an intense, irrational fear, disproportionate to its [[transmission]] potential in the post-[[antibiotic]]/[[vaccination]] era.
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| ====Fundamental works====
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| The fundamental but separate works by Yersin and Kitasato in 1894 on the discovery of the etiologic agent of plague in Hong Kong opened the way for investigating the [[disease]] and how it is spread. Kitasato and Yersin described, within days of each other’s findings, the presence of [[bipolar]] staining [[organisms]] in the [[swollen]] [[lymph node]] ([[bubo]]), [[blood]], [[lungs]], [[liver]] and [[spleen]] of [[dead]] patients (Bibel et al., 1976). Cultures isolated from patient specimens were [[inoculated]] into a variety of laboratory animals, including mice. These animals died within days after [[injection]], and the same bacilli as those found in patient specimens were present in the animal [[organs]]. Though both investigators reported their findings, there were a series of confusing and contradictory statements by Kitasato that eventually led to the acceptance of Yersin as the primary discoverer of the organism now named after him, Yersinia pestis (Bibel et al., 1976). Yersin had recorded that rats were affected by plague not only during plague epidemics but also often preceding such epidemics in humans. In fact, plague was designated, in local languages, as a disease of the rats: villagers in China, India and Formosa (Taiwan) described that when hundreds and thousands of rats lie dead in and out of houses, plague outbreaks in people soon followed (Gross, 1995). The transmission of plague was described by Simond in 1898. He noted that persons who became ill did not have to be in close contact with each other to acquire the [[disease]]. In Yunnan, China, inhabitants would run away from their homes as soon as they saw dead rats. On the island of Formosa, residents considered handling dead rats a risk for developing plague. These observations led Simond to suspect that the flea might be an intermediary factor in the transmission of plague since people acquired plague only if they were in contact with recently dead rats and were not affected if they touched rats that were dead for more than 24 hours. Simond demonstrated that the rat flea (Xenopsylla cheopis) transmitted the disease in a now classic experiment in which a healthy rat, separated from direct contact with a recently plague-killed rat, died of plague after the infected fleas jumped from the first rat to the second.
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| ====Ancient disease====
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| Plague is an ancient [[disease]] that is not likely to disappear; its continued outbreaks throughout the world attest to its tenacious presence. Since the first descriptions, many studies have examined the [[transmission]], [[bubonic plague epidemiology and demographics|epidemiology]] and [[pathogenesis]] of the disease (Gage, 1998). Plague is a [[bacterial infection]] of small mammals transmitted from animal to animal by the [[bite]] of infected fleas. Plague cycles naturally in its [[enzootic foci]], circulating between small mammals and fleas without human involvement. The quiescent periods, during which few or no human cases are detected, may last for years, leading to mistaken declarations of plague eradication. However long the silent periods last, plague may suddenly reappear. The combination of false assurance of its eradication, and the failure of public health vigilance, sets the stage for the panic that may ensue when enzootic plague spills over from its natural cycle into the peridomestic and commensal rodent populations (and their fleas), bringing plague into closer human contact. Poor [[sanitation]], overcrowding and high numbers of rodents are conditions that enhance urban plague transmission. Thus, a plague outbreak has come to represent an indictment of social, environmental and political changes in the modern world.
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| ==References==
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| {{Reflist|2}}
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