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| __NOTOC__
| | #Redirect [[Yersinia pestis infection differential diagnosis]] |
| {{Bubonic plague}}
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| {{CMG}}
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| ==Overview==
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| There are many diseases that resemble the basic [[signs]] and [[symptoms]] of bubonic plague. Since bubonic plague has the ability to kill the majority of a population, it is an extremely concerning diagnosis. Given the grave nature of bubonic plague, it is critical to exclude other diagnoses before a final diagnosis of bubonic plague is made.
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| ==Differentiating Bubonic Plague from other Diseases==
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| ===Bubonic Plague===
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| *[[Streptococcal]] or [[staphylococcal]] [[adenitis]] (''[[Staphylococcus aureus]]'', ''Staphylococcus pyogenes'')
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| **Purulent or inflamed [[lesion]] often noted [[distal]] to involved [[nodes]] (i.e., [[pustule]], infected traumatic lesion).
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| **Involved nodes more likely to be fluctuant.
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| **Associated ascending [[lymphangitis]] or [[cellulitis]] may be present (generally not seen with plague).
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| *[[Tularemia]] (''[[Francisella tularensis]]'')
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| **[[Ulcer]] or [[pustule]] often present distal to involved nodes.
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| **Clinical course rarely as fulminant as in plague.
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| **Systemic toxicity uncommon.
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| *[[Cat scratch fever]] (''[[Bartonella henselae]]'')
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| **History of contact with cats; usually history of cat scratch.
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| **Indolent clinical course; progresses over weeks.
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| **Primary lesion at site of scratch often present (small [[papule]], [[vesicle]]).
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| **Systemic toxicity not present.
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| *[[Mycobacterial infection]], including [[scrofula]] (''[[Mycobacterium tuberculosis]]'' and other Mycobacterium species)
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| **With scrofula, [[adenitis]] occurs in [[cervical]] region.
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| **Usually [[painless]].
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| **Indolent clinical course.
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| **[[Infections]] with species other than M. tuberculosis more likely to occur in [[immunocompromised]] patients.
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| *[[Lymphogranuloma venereum]] (''[[Chlamydia trachomatis]]'')
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| **[[Adenitis]] occurs in the [[inguinal]] region.
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| **History of [[sexual]] exposure 10-30 days previously.
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| **Suppuration, fistula tracts common.
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| **Although LGV [[buboes]] may be somewhat [[tender]], exquisite tenderness usually absent.
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| **Although patients may appear ill ([[headache]], [[fever]], [[myalgias]]), systemic [[toxicity]] not present.
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| *[[Chancroid]] (''[[Haemophilus ducreyi]]'')
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| **Adenitis occurs in the inguinal region.
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| **Ulcerative lesion present.
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| **Systemic symptoms uncommon; toxicity does not occur.
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| *Primary [[genital herpes]]
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| **Herpes lesions present in genital area.
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| **Adenitis occurs in the inguinal region.
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| **Although patients may be ill (fever, headache), severe systemic toxicity not present.
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| *Primary or secondary [[syphilis]] (''[[Treponema pallidum]]'')
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| **Enlarged [[lymph nodes]] in the inguinal region.
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| **Lymph nodes generally painless.
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| **[[Chancre]] may be noted with primary syphilis.
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| *Strangulated inguinal [[hernias]]
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| **Evidence of bowel involvement.
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| ==References==
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| {{Reflist|2}}
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| [[Category:Bacterial diseases]]
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| [[Category:Infectious disease]]
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| [[Category:Epidemics]]
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| [[Category:Pandemics]]
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| [[Category:Zoonoses]]
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| [[Category:Insect-borne diseases]]
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| [[Category:Disease]]
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