Hypercalcemia (patient information): Difference between revisions
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{{Hypercalcemia (patient information)}} | |||
'''For the WikiDoc page for this topic, click [[Hypercalcemia|here]]''' | '''For the WikiDoc page for this topic, click [[Hypercalcemia|here]]''' | ||
{{CMG}} | {{CMG}} {{AE}}; [[User:Daniel Nethala|Daniel Nethala, B.S]] | ||
==Overview== | ==Overview== | ||
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==What causes Hypercalcemia?== | ==What causes Hypercalcemia?== | ||
Primary [[hyperparathyroidism]] is the most common cause of hypercalcemia. It is due to excess [[PTH]] release by the parathyroid glands. This excess occurs due to an enlargement of one or more of the parathyroid glands, or a growth (usually not cancer) on one of the glands. | |||
Primary [[hyperparathyroidism]] is the most common cause of hypercalcemia. It is due to excess PTH release by the parathyroid glands. This excess occurs due to an enlargement of one or more of the parathyroid glands, or a growth (usually not cancer) on one of the glands. | |||
Other medical conditions can also cause hypercalcemia: | Other medical conditions can also cause hypercalcemia: | ||
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* Some cancerous tumors (for example, lung cancers, breast cancer) | * Some cancerous tumors (for example, lung cancers, breast cancer) | ||
* Vitamin D excess (hypervitaminosis D) from diet or inflammatory diseases | * Vitamin D excess (hypervitaminosis D) from diet or inflammatory diseases | ||
==Who is at highest risk?== | ==Who is at highest risk?== | ||
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==When to seek urgent medical care?== | ==When to seek urgent medical care?== | ||
Hypercalcemia affects less than 1 percent of the population. The ability to measure blood calcium since the 1960s has improved detection. Today, the condition is diagnosed at an early stage so most patients with hypercalcemia have no symptoms. | |||
Contact your physician or health care provider if you have: | Contact your physician or health care provider if you have: | ||
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==Diagnosis== | ==Diagnosis== | ||
The cause of [[hypercalcemia]] must be identified, if possible, for this the physician may decide to obtain the following biomarkers: | |||
* Serum [[calcium]] | |||
* Serum [[PTH]] | |||
* Serum PTHrP (PTH-related protein) | |||
* Serum [[vitamin D]] level | |||
* Urine [[calcium]] | |||
==Treatment options== | ==Treatment options== | ||
Treatment is aimed at the cause of hypercalcemia whenever possible. In people with primary [[hyperparathyroidism]] (PHPT), surgery may be needed to remove the abnormal parathyroid gland and cure the hypercalcemia. | |||
However, if the hypercalcemia is mild, your health care provider will offer you the option of monitoring your condition closely over time. | |||
Severe [[hypercalcemia]] that causes symptoms and requires a hospital stay is treated with the following: | |||
*[[Calcitonin]] | |||
*[[Dialysis]] | |||
*[[Diuretic]] medication, such as [[furosemide]] | |||
*Drugs that stop bone breakdown and absorption by the body, such as [[pamidronate]] or [[etidronate]] (bisphosphonates) | |||
*Fluids through a vein (intravenous fluids) | |||
*[[Glucocorticoids]] (steroids) | |||
====Medications to avoid==== | |||
{{MedCondContrPI | |||
= | |MedCond = hypercalcemia|Oxandrolone|Spironolactone}} | ||
==Where to find medical care for | ==Where to find medical care for Hypercalcemia?== | ||
[http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+ | [http://maps.google.com/maps?q={{urlencode:{{#if:{{{1|}}}|{{{1}}}|map+top+hospital+Hypercalcemia}}}}&oe=utf-8&rls=org.mozilla:en-US:official&client=firefox-a&um=1&ie=UTF-8&sa=N&hl=en&tab=wl Directions to Hospitals Treating Hypercalcemia] | ||
==What to expect (Outlook/Prognosis)?== | ==What to expect (Outlook/Prognosis)?== | ||
How well you do depends on the cause of hypercalcemia. Patients with mild hyperparathyroidism or hypercalcemia with a treatable cause do well and usually do not have complications. | |||
Patients with hypercalcemia due to conditions such as cancer or granulomatous disease may not do well, but this is usually due to the disease itself, rather than the hypercalcemia. | |||
==Possible complications== | ==Possible complications== | ||
'''Gastrointestinal:''' | |||
* [[Pancreatitis]] | |||
* [[Peptic ulcer disease]] | |||
'''Kidney:''' | |||
*Calcium deposits in the kidney ([[nephrocalcinosis]]) | |||
*[[Dehydration]] | |||
*[[hypertension|High blood pressure]] | |||
*[[Kidney failure]] | |||
*[[Kidney stones]] | |||
'''Psychological:''' | |||
*[[Depression]] | |||
*Difficulty concentrating or thinking | |||
'''Skeletal:''' | |||
*Bone [[cysts]] | |||
*[[Fractures]] | |||
*[[Osteoporosis]] | |||
These complications of long-term hypercalcemia are uncommon today. | |||
==Prevention== | ==Prevention== | ||
Most causes of [[hypercalcemia]] cannot be prevented. Women over age 50 should see their health care provider regularly and have their blood calcium level checked if they have symptoms of hypercalcemia. | |||
You can avoid hypercalcemia from calcium and vitamin D supplements by contacting your health care provider for advice about the dose if you are taking supplements without a prescription. | |||
==Sources== | ==Sources== | ||
http://www.nlm.nih.gov/medlineplus/ency/article/000365.htm | |||
Latest revision as of 18:55, 7 January 2015
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Hypercalcemia |
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Hypercalcemia On the Web |
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For the WikiDoc page for this topic, click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: ; Daniel Nethala, B.S
Overview
Hypercalcemia is a disorder in which there is too much calcium in the blood.
What are the symptoms of Hypercalcemia?
Abdominal symptoms:
- Constipation
- Nausea
- Pain
- Poor appetite
- Vomiting
Kidney symptoms:
Muscle symptoms:
Psychological symptoms:
Skeletal symptoms:
- Bone pain
- Bowing of the shoulders
- Fractures due to disease (pathological fractures)
- Loss of height
- Spinal column curvature
What causes Hypercalcemia?
Primary hyperparathyroidism is the most common cause of hypercalcemia. It is due to excess PTH release by the parathyroid glands. This excess occurs due to an enlargement of one or more of the parathyroid glands, or a growth (usually not cancer) on one of the glands.
Other medical conditions can also cause hypercalcemia:
- Adrenal gland failure
- An inherited condition that affects the body's ability to regulate calcium (familial hypocalciuric hypercalcemia)
- Being bedbound (or not being able to move) for a long period of time
- Calcium excess in the diet (called milk-alkali syndrome, usually due to at least 2,000 milligrams of calcium per day)
- Hyperthyroidism
- Kidney failure
- Medications such as lithium and thiazide diuretics (water pills)
- Some cancerous tumors (for example, lung cancers, breast cancer)
- Vitamin D excess (hypervitaminosis D) from diet or inflammatory diseases
Who is at highest risk?
Women over age 50 are most likely to have hypercalcemia, usually due to primary hyperparathyroidism.
When to seek urgent medical care?
Hypercalcemia affects less than 1 percent of the population. The ability to measure blood calcium since the 1960s has improved detection. Today, the condition is diagnosed at an early stage so most patients with hypercalcemia have no symptoms.
Contact your physician or health care provider if you have:
- Family history of hypercalcemia
- Family history of hyperparathyroidism
- Symptoms of hypercalcemia
Diagnosis
The cause of hypercalcemia must be identified, if possible, for this the physician may decide to obtain the following biomarkers:
Treatment options
Treatment is aimed at the cause of hypercalcemia whenever possible. In people with primary hyperparathyroidism (PHPT), surgery may be needed to remove the abnormal parathyroid gland and cure the hypercalcemia.
However, if the hypercalcemia is mild, your health care provider will offer you the option of monitoring your condition closely over time.
Severe hypercalcemia that causes symptoms and requires a hospital stay is treated with the following:
- Calcitonin
- Dialysis
- Diuretic medication, such as furosemide
- Drugs that stop bone breakdown and absorption by the body, such as pamidronate or etidronate (bisphosphonates)
- Fluids through a vein (intravenous fluids)
- Glucocorticoids (steroids)
Medications to avoid
Patients diagnosed with hypercalcemia should avoid using the following medications:
- Oxandrolone
- Spironolactone
If you have been diagnosed with hypercalcemia, consult your physician before starting or stopping any of these medications.
Where to find medical care for Hypercalcemia?
Directions to Hospitals Treating Hypercalcemia
What to expect (Outlook/Prognosis)?
How well you do depends on the cause of hypercalcemia. Patients with mild hyperparathyroidism or hypercalcemia with a treatable cause do well and usually do not have complications.
Patients with hypercalcemia due to conditions such as cancer or granulomatous disease may not do well, but this is usually due to the disease itself, rather than the hypercalcemia.
Possible complications
Gastrointestinal:
Kidney:
- Calcium deposits in the kidney (nephrocalcinosis)
- Dehydration
- High blood pressure
- Kidney failure
- Kidney stones
Psychological:
- Depression
- Difficulty concentrating or thinking
Skeletal:
- Bone cysts
- Fractures
- Osteoporosis
These complications of long-term hypercalcemia are uncommon today.
Prevention
Most causes of hypercalcemia cannot be prevented. Women over age 50 should see their health care provider regularly and have their blood calcium level checked if they have symptoms of hypercalcemia.
You can avoid hypercalcemia from calcium and vitamin D supplements by contacting your health care provider for advice about the dose if you are taking supplements without a prescription.