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| {{SI}}
| | #REDIRECT [[Lorcaserin Hydrochloride Hemihydrate]] |
| {{CMG}}
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| ==Overview==
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| Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has [[serotonergic]] properties and acts as an [[anorectic]]. On 27 June 2012, the [[Food and Drug Administration|FDA]] officially approved lorcaserin for use in the treatment of [[obesity]] for adults with a [[BMI]] equal to or greater than 30 or adults with a BMI of 27 or greater who "have at least one weight-related health condition, such as high [[blood pressure]], [[type 2 diabetes]], or high [[cholesterol]]".
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| ==Mechanism of action==
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| Lorcaserin is a selective [[5-HT2C receptor|5-HT<sub>2C</sub> receptor]] [[agonist]] and ''in vitro'' testing of the drug showed reasonable selectivity for 5-HT<sub>2C</sub> over other related targets.
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| 5-HT<sub>2C</sub> receptors are located almost exclusively in the brain, and can also be found in the [[choroid plexus]], [[Cerebral cortex|cortex]], [[hippocampus]], [[cerebellum]], [[amygdala]], [[thalamus]], and [[hypothalamus]].
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| The activation of 5-HT<sub>2C</sub> receptors in the hypothalamus is supposed to activate [[proopiomelanocortin]] (POMC) production and consequently promote weight loss through [[satiety]]. This hypothesis is supported by clinical trials and other studies.
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| ==Side effects==
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| Lorcaserin was approximately as tolerable as placebo in Phase III, with 7% of participants in both the lorcaserin drug and placebo arms dropping out due to side effects. | |
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| The side effects noted with the drug compared to placebo are as follows:
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| {| class=wikitable border=1
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| !Side effects
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| !Placebo (%)
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| !Drug arm (%)
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| |-
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| |[[Headache]] (most common)
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| |11
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| |18
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| |-
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| |[[Upper respiratory tract infection]]
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| |11.9
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| |14.8
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| |-
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| |[[Nasopharyngitis]]
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| |12.0
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| |13.4
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| |-
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| |[[Nausea]]
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| |5.4
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| |7.5
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| |-
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| |}
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antiobesity drugs]]
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| [[Category:Serotonin receptor agonists]]
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| [[Category:Organochlorides]]
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| [[Category:Benzazepines]]
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| {{WH}}
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| {{WS}}
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