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| __NOTOC__
| | #redirect:[[Sulfanilamide (Cream)]] |
| {{Sulfanilamide}}
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| '''''For patient information, click <u>[[Sulfanilamide (patient information)|here]]'''''</u>.
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| {{CMG}}; {{AE}} {{MM}}
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| ==Overview==
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| '''Sulfanilamide''' (also spelled '''sulphanilamide''') is a [[sulfonamide (medicine)|sulfonamide]] [[antibacterial]]. Chemically, it is a molecule containing the [[Sulfonamide (chemistry)|sulfonamide]] functional group attached to an [[aniline]].
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| Sulfanilamide was first prepared in 1908 by Paul Gelmo as part of his dissertation for a doctoral degree from the Technische Hochsschule of Vienna, Austria.<ref>Paul Gelmo (May 14, 1908) [http://gallica.bnf.fr/ark:/12148/bpt6k90849c/f378.image "Über Sulfamide der p-Amidobenzolsulfonsäure,"] ''Journal für Praktische Chemie'', '''77''' : 369-382.</ref> It was patented in 1909.<ref>On May 18, 1909, Deutsches Reich Patentschrift number 226,239 for sulfanilamide was awarded to Heinrich Hörlein of the Bayer corporation.</ref>
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| ==Category==
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| [[Sulfonamide]]
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| ==US Brand Names==
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| AVC VAGINAL<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[Sulfanilamide description|Description]]'''
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| '''| [[Sulfanilamide clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Sulfanilamide indications and usage|Indications and Usage]]'''
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| '''| [[Sulfanilamide contraindications|Contraindications]]'''
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| '''| [[Sulfanilamide warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Sulfanilamide adverse reactions|Adverse Reactions]]'''
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| '''| [[Sulfanilamide overdosage|Overdosage]]'''
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| '''| [[Sulfanilamide dosage and administration|Dosage and Administration]]'''
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| '''| [[Sulfanilamide how supplied|How Supplied]]'''
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| '''| [[Sulfanilamide labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| As a sulfonamide antibiotic, it functions by competitively inhibiting (i.e., by acting as a substrate analogue) enzymatic reactions involving [[para-aminobenzoic acid]] (PABA).<ref>Michael Kent, ''Advanced Biology,'' Oxford University Press, 2000, p. 46 ISBN 978-0-19-914195-1</ref> PABA is needed in enzymatic reactions that produce [[folic acid]] which acts as a coenzyme in the synthesis of purine, pyrimidine and other amino acids.
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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