Veno-occlusive disease: Difference between revisions

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VisualWikitext

Latest revision as of 16:46, 27 January 2015

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and Keywords: VOD, sinuosoidal obstruction syndrome

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Drug induced

Dactinomycin

Differentiating Veno-occlusive disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

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 __NOTOC__
-{{SI}}
+'''For patient information, click [[Veno-occlusive disease (patient information)|here]]'''
+{{Veno-occlusive_disease}}
 {{CMG}}
 '''''Synonyms and Keywords:''''' VOD, sinuosoidal obstruction syndrome
-==Overview==
+==[[Veno-occlusive disease overview|Overview]]==
-Veno-occlusive disease (VOD) is a disease of the liver in which the veins in the liver are obstructed or blocked.  VOD is a complication that occurs in up to 25% of [[bone marrow transplant]]ations, and may also occur after ingestion of certain plant [[alkaloids]].
-==Prognosis==
+==[[Veno-occlusive disease historical perspective|Historical Perspective]]==
-When associated with bone marrow transplant, VOD is fatal in over 30% of cases. Cases due to plant alkaloids often have a longer and more unpredictable course.
-==Diagnosis==
+==[[Veno-occlusive disease classification|Classification]]==
-===Symptoms===
-*[[Weight gain]]
+==[[Veno-occlusive disease pathophysiology|Pathophysiology]]==
-*[[Right upper quadrant pain]] due to [[hepatomegaly]]
-*[[Abdominal swelling]] due to [[ascites]]
+==[[Veno-occlusive disease causes|Causes]]==
+===Drug induced===
+* [[Dactinomycin]]
+==[[Veno-occlusive disease differential diagnosis|Differentiating Veno-occlusive disease from other Diseases]]==
+==[[Veno-occlusive disease epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Veno-occlusive disease risk factors|Risk Factors]]==
-===Physical Examination===
+==[[Veno-occlusive disease screening|Screening]]==
-====Abdominal Examination====
-*Tender [[hepatomegaly]]
-*[[Ascites]]
-===Laboratory Studies===
+==[[Veno-occlusive disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-*Increased [[bilirubin]]
-*[[Renal failure]] may be present
-==Pathophysiology==
+==Diagnosis==
-In the BMT setting, VOD is felt to due to injury to the hepatic venous endothelium from the conditioning regimen. It is also known as '''sinuosoidal obstruction syndrome'''.
+[[Veno-occlusive disease history and symptoms|History and Symptoms]] | [[Veno-occlusive disease physical examination|Physical Examination]] | [[Veno-occlusive disease laboratory findings|Laboratory Findings]] | [[Veno-occlusive disease abdominal x ray|Abdominal X Ray]] | [[Veno-occlusive disease CT|CT]] | [[Veno-occlusive disease MRI|MRI]] | [[Veno-occlusive disease ultrasound|Ultrasound]] | [[Veno-occlusive disease other imaging findings|Other Imaging Findings]] | [[Veno-occlusive disease other diagnostic studies|Other Diagnostic Studies]]
 ==Treatment==
-Treatment for VOD is primarily supportive. In the BMT setting, [[defibrotide]] is an investigational treatment that may be promising.  Defibrotide is a polydeoxyribonucleotide; its mechanism of benefit in VOD is unclear, but has been attributed to its antithromboitc properties.
+[[Veno-occlusive disease medical therapy|Medical Therapy]] | [[Veno-occlusive disease surgery|Surgery]] | [[Veno-occlusive disease primary prevention|Primary Prevention]] | [[Veno-occlusive disease secondary prevention|Secondary Prevention]] | [[Veno-occlusive disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Veno-occlusive disease future or investigational therapies|Future or Investigational Therapies]]
-==Sources==
-Kumar, V., Abbas, A. and N. Fausto. 2004. ''Robbins & Cotran Pathologic Basis of Disease.'' Philadelphia: W. B. Saunders Company.
-==References==
+==Case Studies==
-{{Reflist|2}}
-==External link==
+[[Veno-occlusive disease case study one|Case #1]]
-* [http://www.asheducationbook.org/cgi/content/full/2004/1/372 American Society of Hematology education book] discussion of VOD
 [[Category:Hepatology]]
 [[Category:Hematology]]

Veno-occlusive disease: Difference between revisions

Latest revision as of 16:46, 27 January 2015

Drug induced

Diagnosis

Treatment

Case Studies

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