Torsades de pointes causes: Difference between revisions
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==Overview== | ==Overview== | ||
Common causes for torsades de pointes include [[hypomagnesemia]] and [[hypokalemia]]. It is commonly seen in malnourished individuals and chronic [[alcoholism|alcoholics]]. Drug interactions such as [[erythromycin]] or Avelox, taken concomitantly with inhibitors like [[nitroimidazole]], [[diarrhea]], dietary supplements, and various medications like [[methadone]], [[lithium]], [[tricyclic antidepressants]] or [[phenothiazines]] may also contribute to causing torsades de pointes. | |||
==Causes== | ==Causes== | ||
===The List of Drugs that Cause Torsades de pointes=== | ===The List of Drugs that Cause Torsades de pointes=== | ||
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* [[Arsenic trioxide ]] | * [[Arsenic trioxide ]] | ||
* [[Astemizole ]] | * [[Astemizole ]] | ||
*[[Azithromycin]] | |||
* [[Bepridil ]] | * [[Bepridil ]] | ||
* [[Chloroquine ]] | * [[Chloroquine ]] | ||
* [[Chlorpromazine ]] | * [[Chlorpromazine ]] | ||
* [[Cisapride ]] | * [[Cisapride ]] | ||
* Citalopram | |||
* [[Clarithromycin ]] | * [[Clarithromycin ]] | ||
* [[Disopyramide ]] | * [[Disopyramide ]] | ||
* [[Dofetilide ]] | * [[Dofetilide ]] | ||
* [[Dolasetron mesylate]] | |||
* [[Domperidone ]] | * [[Domperidone ]] | ||
* [[Droperidol ]] | * [[Droperidol ]] | ||
* [[Erythromycin ]] | * [[Erythromycin ]] | ||
* [[Felbamate]] | |||
* [[Halofantrine ]] | * [[Halofantrine ]] | ||
* [[Haloperidol ]] | * [[Haloperidol ]] | ||
* [[Clozapine]] | |||
* [[Ibutilide ]] | * [[Ibutilide ]] | ||
* [[Levomethadyl ]] | * [[Levomethadyl ]] | ||
* [[Mesoridazine]] | * [[Mesoridazine]] | ||
* [[Methadone ]] | * [[Methadone ]] | ||
* [[Moxifloxacin]] | |||
* [[Pentamidine]] | * [[Pentamidine]] | ||
* [[Pimozide ]] | * [[Pimozide ]] | ||
| Line 54: | Line 43: | ||
* [[Procainamide]] | * [[Procainamide]] | ||
* [[Quinidine ]] | * [[Quinidine ]] | ||
*[[Sevoflurane]] | |||
* [[Sotalol ]] | * [[Sotalol ]] | ||
* [[Sparfloxacin ]] | * [[Sparfloxacin ]] | ||
* [[Terfenadine ]] | * [[Terfenadine ]] | ||
* [[Thioridazine]] | * [[Thioridazine]] | ||
* [[Toremifene]] | |||
* [[Vandetanib]] | |||
===Drugs that Possibly Cause Torsades de pointes === | ===Drugs that Possibly Cause Torsades de pointes === | ||
| Line 65: | Line 57: | ||
* [[Alfuzosin ]] | * [[Alfuzosin ]] | ||
* [[Amantadine ]] | * [[Amantadine ]] | ||
*[[Artenimol]] and [[piperaquine]] | |||
* [[Atazanavir ]] | * [[Atazanavir ]] | ||
* [[Azithromycin ]] | * [[Azithromycin ]] | ||
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* [[Clozapine ]] | * [[Clozapine ]] | ||
* [[Dolasetron ]] | * [[Dolasetron ]] | ||
*[[Dronedarone]] | |||
* [[Eribulin]] | |||
* [[Escitalopram]] | |||
*[[Famotidine]] | |||
* [[Felbamate ]] | * [[Felbamate ]] | ||
*[[Fingolimod]] | |||
* [[Flecainide ]] | * [[Flecainide ]] | ||
* [[Foscarnet ]] | * [[Foscarnet ]] | ||
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* [[Gemifloxacin ]] | * [[Gemifloxacin ]] | ||
* [[Granisetron ]] | * [[Granisetron ]] | ||
*[[Iloperidone]] | |||
* [[Indapamide ]] | * [[Indapamide ]] | ||
* [[Isradipine ]] | * [[Isradipine ]] | ||
*[[Lapatanib]] | |||
* [[Levofloxacin ]] | * [[Levofloxacin ]] | ||
* [[Lithium ]] | * [[Lithium ]] | ||
* [[Mirtazipine]] | |||
* [[Moexipril]] / [[HCTZ ]] | * [[Moexipril]] / [[HCTZ ]] | ||
* [[Moxifloxacin ]] | * [[Moxifloxacin ]] | ||
* [[Nicardipine ]] | * [[Nicardipine ]] | ||
*[[Nilotinib]] | |||
* [[Octreotide ]] | * [[Octreotide ]] | ||
* [[Ofloxacin ]] | * [[Ofloxacin ]] | ||
| Line 94: | Line 96: | ||
* [[Risperidone ]] | * [[Risperidone ]] | ||
* [[Roxithromycin]] | * [[Roxithromycin]] | ||
*[[Sertindole]] | |||
* [[Sunitinib ]] | * [[Sunitinib ]] | ||
* [[Tacrolimus ]] | * [[Tacrolimus ]] | ||
| Line 101: | Line 104: | ||
* [[Vardenafil ]] | * [[Vardenafil ]] | ||
* [[Venlafaxine ]] | * [[Venlafaxine ]] | ||
* [[vandetanib]] | |||
* [[Voriconazole ]] | * [[Voriconazole ]] | ||
* [[Ziprasidone]] | * [[Ziprasidone]] | ||
| Line 108: | Line 112: | ||
Drugs that, in some reports, have been weakly associated with torsades de pointes and/or QT prolongation but that are unlikely to be a risk for torsades de pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism) | Drugs that, in some reports, have been weakly associated with torsades de pointes and/or QT prolongation but that are unlikely to be a risk for torsades de pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism) | ||
*[[Amisulpride]] | |||
* [[Amitriptyline ]] | * [[Amitriptyline ]] | ||
* [[Amoxapine ]] | * [[Amoxapine ]] | ||
| Line 114: | Line 119: | ||
* [[Clomipramine ]] | * [[Clomipramine ]] | ||
* [[Desipramine ]] | * [[Desipramine ]] | ||
*[[Diphenhydramine]] | |||
* [[Doxepin ]] | * [[Doxepin ]] | ||
* [[Fluconazole ]] | * [[Fluconazole ]] | ||
| Line 124: | Line 130: | ||
* [[Nortriptyline]] | * [[Nortriptyline]] | ||
* [[Paroxetine ]] | * [[Paroxetine ]] | ||
* [[Protriptyline]] | * [[Protriptyline]] | ||
*[[Ritonavir]] | |||
* [[Sertraline ]] | * [[Sertraline ]] | ||
* [[Solifenacin ]] | * [[Solifenacin ]] | ||
*[[Trazodone]] | |||
* [[Trimethoprim-Sulfamethoxazole]] | * [[Trimethoprim-Sulfamethoxazole]] | ||
* [[Trimipramine]] | * [[Trimipramine]] | ||
==Sources== | |||
http://www.qtdrugs.org/ | |||
==References== | ==References== | ||
Latest revision as of 20:38, 16 February 2015
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Torsades de pointes Microchapters |
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Torsades de pointes causes On the Web |
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American Roentgen Ray Society Images of Torsades de pointes causes |
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Risk calculators and risk factors for Torsades de pointes causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Common causes for torsades de pointes include hypomagnesemia and hypokalemia. It is commonly seen in malnourished individuals and chronic alcoholics. Drug interactions such as erythromycin or Avelox, taken concomitantly with inhibitors like nitroimidazole, diarrhea, dietary supplements, and various medications like methadone, lithium, tricyclic antidepressants or phenothiazines may also contribute to causing torsades de pointes.
Causes
The List of Drugs that Cause Torsades de pointes
Drugs that are generally accepted to have a risk of causing torsades de pointes:
- Amiodarone
- Arsenic trioxide
- Astemizole
- Azithromycin
- Bepridil
- Chloroquine
- Chlorpromazine
- Cisapride
- Citalopram
- Clarithromycin
- Disopyramide
- Dofetilide
- Dolasetron mesylate
- Domperidone
- Droperidol
- Erythromycin
- Felbamate
- Halofantrine
- Haloperidol
- Clozapine
- Ibutilide
- Levomethadyl
- Mesoridazine
- Methadone
- Moxifloxacin
- Pentamidine
- Pimozide
- Probucol
- Procainamide
- Quinidine
- Sevoflurane
- Sotalol
- Sparfloxacin
- Terfenadine
- Thioridazine
- Toremifene
- Vandetanib
Drugs that Possibly Cause Torsades de pointes
Drugs that in some reports have been associated with torsades de pointes and/or QT prolongation but at this time lack substantial evidence for causing torsades de pointes.
- Alfuzosin
- Amantadine
- Artenimol and piperaquine
- Atazanavir
- Azithromycin
- Chloral hydrate
- Clozapine
- Dolasetron
- Dronedarone
- Eribulin
- Escitalopram
- Famotidine
- Felbamate
- Fingolimod
- Flecainide
- Foscarnet
- Fosphenytoin
- Gatifloxacin
- Gemifloxacin
- Granisetron
- Iloperidone
- Indapamide
- Isradipine
- Lapatanib
- Levofloxacin
- Lithium
- Mirtazipine
- Moexipril / HCTZ
- Moxifloxacin
- Nicardipine
- Nilotinib
- Octreotide
- Ofloxacin
- Ondansetron
- Oxytocin
- Paliperidone
- Perflutren
- Quetiapine
- Ranolazine
- Risperidone
- Roxithromycin
- Sertindole
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telithromycin
- Tizanidine
- Vardenafil
- Venlafaxine
- vandetanib
- Voriconazole
- Ziprasidone
The List of Drugs that Cause Torsades de pointes in Certain Conditions
Drugs that, in some reports, have been weakly associated with torsades de pointes and/or QT prolongation but that are unlikely to be a risk for torsades de pointes when used in usual recommended dosages and in patients without other risk factors (e.g., concomitant QT prolonging drugs, bradycardia, electrolyte disturbances, congenital long QT syndrome, concomitant drugs that inhibit metabolism)
- Amisulpride
- Amitriptyline
- Amoxapine
- Ciprofloxacin
- Citalopram
- Clomipramine
- Desipramine
- Diphenhydramine
- Doxepin
- Fluconazole
- Fluoxetine
- Galantamine
- Imipramine
- Itraconazole
- Ketoconazole
- Mexiletine
- Nortriptyline
- Paroxetine
- Protriptyline
- Ritonavir
- Sertraline
- Solifenacin
- Trazodone
- Trimethoprim-Sulfamethoxazole
- Trimipramine