Sulfiram: Difference between revisions
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==Overview== | |||
'''Sulfiram''' ([[International Nonproprietary Name|INN]]) or '''monosulfiram''', trade name '''Tetmosol''', is an [[ectoparasiticide]] used in the treatment and prevention of [[scabies]].<ref name=Martindale>{{cite book |editor=Sweetman, Sean C. |chapter=Pesticides and repellents |title=Martindale: the complete drug reference |edition=36th |year=2009 |page=2050 |publisher=Pharmaceutical Press |location=London |isbn=978-0-85369-840-1}}</ref> It is usually sold as a solution or medicated [[soap]], sometimes in combination with [[benzyl benzoate]]. | '''Sulfiram''' ([[International Nonproprietary Name|INN]]) or '''monosulfiram''', trade name '''Tetmosol''', is an [[ectoparasiticide]] used in the treatment and prevention of [[scabies]].<ref name=Martindale>{{cite book |editor=Sweetman, Sean C. |chapter=Pesticides and repellents |title=Martindale: the complete drug reference |edition=36th |year=2009 |page=2050 |publisher=Pharmaceutical Press |location=London |isbn=978-0-85369-840-1}}</ref> It is usually sold as a solution or medicated [[soap]], sometimes in combination with [[benzyl benzoate]]. |
Latest revision as of 13:07, 11 March 2015
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Clinical data | |
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AHFS/Drugs.com | International Drug Names |
Routes of administration | Topical |
ATCvet code | |
Pharmacokinetic data | |
Bioavailability | Very low |
Excretion | Renal, unchanged |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C10H20N2S3 |
Molar mass | 264.47 g·mol−1 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sree Teja Yelamanchili, MBBS [2]
Overview
Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.
Sulfiram is now rarely used, but, as of 2010[update], is still available in Brazil, India, and South Africa (as monotherapy) and France (with benzyl benzoate).[1]
Adverse effects
Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]
Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1][4]
References
- ↑ 1.0 1.1 1.2 Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
- ↑ [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
- ↑ Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
- ↑ Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.
External links
- Tetmosol* soap – South African Electronic Package Insert
- Pages with script errors
- CS1 maint: Unrecognized language
- CS1 maint: Multiple names: authors list
- Template:drugs.com link with non-standard subpage
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without InChI source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Articles containing potentially dated statements from 2010
- Articles with invalid date parameter in template
- All articles containing potentially dated statements
- Dithiocarbamates